Wearable high-density diffuse optical tomography (WHD-DOT) instrument for mapping human brain activity

Agato, Alvin; Richter, Edward J.; Svoboda, Calamity; Sherafati, Arefeh; Burke, Broc; Eggebrecht, Adam T.; Culver, Joseph P.

doi:10.1117/12.2579116

Cited by 4 publications

(7 citation statements)

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“…Reproduced with permission, courtesy of SPIE. (d) In-house CW wearable HD-DOT system 37 . Reproduced with permission, courtesy of SPIE.…”

Section: How We Got Herementioning

confidence: 99%

“…43 In the last year, several other wearable HD systems have begun to emerge. For example, Agato et al 37 introduced a fiberless wearable HD-DOT system that employs pencil-like sources and detectors that brush through hair and provide robust optode coupling [Fig. 2(d)].…”

Section: How We Got Herementioning

confidence: 99%

“…(d) In-house CW wearable HD-DOT system. 37 Reproduced with permission, courtesy of SPIE. (e) Kernel flow: first wearable time-domain DOT system.…”

Section: How We Got Herementioning

confidence: 99%

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Wearable, high-density fNIRS and diffuse optical tomography technologies: a perspective

et al. 2023

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Recent progress in optoelectronics has made wearable and high-density functional near-infrared spectroscopy (fNIRS) and diffuse optical tomography (DOT) technologies possible for the first time. These technologies have the potential to open new fields of real-world neuroscience by enabling functional neuroimaging of the human cortex at a resolution comparable to fMRI in almost any environment and population. In this perspective article, we provide a brief overview of the history and the current status of wearable high-density fNIRS and DOT approaches, discuss the greatest ongoing challenges, and provide our thoughts on the future of this remarkable technology.

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“…Reproduced with permission, courtesy of SPIE. (d) In-house CW wearable HD-DOT system 37 . Reproduced with permission, courtesy of SPIE.…”

Section: How We Got Herementioning

confidence: 99%

Section: How We Got Herementioning

confidence: 99%

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Wearable, high-density fNIRS and diffuse optical tomography technologies: a perspective

et al. 2023

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“…While we use a fiber-based HD-DOT system, we anticipate that these results will translate to future wearable HD-DOT systems, as long as the systems match the critical performance metrics of fiber-based HD-DOT. 21 Visual decoding was one of the first steps in the chain of advances in fMRI decoding during the last decade, 1,2 and here we begin translating that progress to HD-DOT.…”

Section: Introductionmentioning

confidence: 95%

Identifying Naturalistic Movies from Human Brain Activity with High-Density Diffuse Optical Tomography

Markow,

Tripathy,

Svoboda

et al. 2023

Preprint

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Modern neuroimaging modalities, particularly functional MRI (fMRI), can decode detailed human experiences. Thousands of viewed images can be identified or classified, and sentences can be reconstructed. Decoding paradigms often leverage encoding models that reduce the stimulus space into a smaller yet generalizable feature set. However, the neuroimaging devices used for detailed decoding are non-portable, like fMRI, or invasive, like electrocorticography, excluding application in naturalistic use. Wearable, non-invasive, but lower-resolution devices such as electroencephalography and functional near-infrared spectroscopy (fNIRS) have been limited to decoding between stimuli used during training. Herein we develop and evaluate model-based decoding with high-density diffuse optical tomography (HD-DOT), a higher-resolution expansion of fNIRS with demonstrated promise as a surrogate for fMRI. Using a motion energy model of visual content, we decoded the identities of novel movie clips outside the training set with accuracy far above chance for single-trial decoding. Decoding was robust to modulations of testing time window, different training and test imaging sessions, hemodynamic contrast, and optode array density. Our results suggest that HD-DOT can translate detailed decoding into naturalistic use.

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“…20 More recently, fiberless HD-DOT systems have retained the same optode design but with active electro-optics. 17,[21][22][23][24][25][26] These HD-DOT designs can be leveraged for designing SCOT systems. Recent SCOS studies show that cost-efficient multimode fibers (MMFs) are suitable for SCOS/SCOT, [27][28][29] wherein speckle statistics are preserved through the MMFs and flow information is relayed, e.g., for pulsatile blood flow.…”

Section: Introductionmentioning

confidence: 99%

Anatomical Modeling and Optimization of Speckle Contrast Optical Tomography

Lin,

Orukari,

Frisk

et al. 2023

Preprint

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Traditional methods for mapping cerebral blood flow (CBF), such as positron emission tomography and magnetic resonance imaging, offer only isolated snapshots of CBF due to scanner logistics. Speckle contrast optical tomography (SCOT) is a promising optical technique for mapping CBF. However, while SCOT has been established in mice, the method has not yet been demonstrated in humans - partly due to a lack of anatomical reconstruction methods and uncertainty over the optimal design parameters. Herein we develop SCOT reconstruction methods that leverage MRI-based anatomical head models and finite-element modeling of the SCOT forward problem (NIRFASTer). We then simulate SCOT for CBF perturbations to evaluate sensitivity of imaging performance to exposure time and SD-distances. We find image resolution comparable to intensity-based diffuse optical tomography at superficial cortical tissue depth (~1.5 cm). Localization errors can be reduced by including longer SD-measurements. With longer exposure times speckle contrast decreases, however, noise decreases faster, resulting in a net increase in SNR. Specifically, extending exposure time from 10μs to 10ms increased SCOT SNR by 1000X. Overall, our modeling methods provide anatomically-based image reconstructions that can be used to evaluate a broad range of tissue conditions, measurement parameters, and noise sources and inform SCOT system design.

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Wearable high-density diffuse optical tomography (WHD-DOT) instrument for mapping human brain activity

Cited by 4 publications

References 0 publications

Wearable, high-density fNIRS and diffuse optical tomography technologies: a perspective

Wearable, high-density fNIRS and diffuse optical tomography technologies: a perspective

Identifying Naturalistic Movies from Human Brain Activity with High-Density Diffuse Optical Tomography

Anatomical Modeling and Optimization of Speckle Contrast Optical Tomography

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