Wearable electrochemical alcohol biosensors

Campbell, Alan S.; Kim, Jayoung; Wang, Joseph

doi:10.1016/j.coelec.2018.05.014

Cited by 110 publications

(71 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to these limitations, researchers have sought a biometric solution, such as measuring alcohol in blood, breath, or urine. However, biomarkers such as breath or blood alcohol concentration (BrAC/ BAC) are limited in their window of detection and again require repeated active participation during drinking events (Campbell et al, 2018;Hill-Kapturczak et al, 2014;Karns-Wright et al, 2017;Swift, 2000).…”

mentioning

confidence: 99%

Wearable Transdermal Alcohol Monitors: A Systematic Review of Detection Validity, and Relationship Between Transdermal and Breath Alcohol Concentration and Influencing Factors

Egmond

Wright

Livingston

et al. 2020

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background: Research on alcohol consumption mostly relies on self-reported data, which are subject to recall bias. Wearable transdermal alcohol concentration (TAC) monitors address this limitation by continuously measuring the ethanol excreted via the skin. This systematic review aims to provide an overview of TAC monitors' reliability to detect alcohol consumption and methods to estimate breath alcohol concentration (BrAC) and number of standard drinks consumed in a given time frame. Methods: The databases MEDLINE, PsycINFO, SCOPUS, Engineering Village, and CINAHL were systematically searched to identify 1,048 empirical research papers published from 2013 onwards, of which 13 were included after full-text screening. The selected studies included 3 TAC monitors: SCRAM TM , WristTAS TM , and Skyn TM. Results: TAC measures of SCRAM, WrisTAS, and Skyn are found to be positively correlated with BrAC (r = 0.56 to 0.79) and/or self-reports (r = 0.62). Using the AMS criteria for detection results in low sensitivity, adjusted criteria can increase the sensitivity of the SCRAM from 39.9 to 68.5%. The WrisTAS and an early prototype of the Skyn showed high failure rates (17 to 38%). Recent advances toward transforming the TAC data into more clinically relevant measures have led to the development of mathematical models and the BrAC Estimator Software. Using TAC data, both approaches produce estimates explaining 70 to 82% of actual BrAC and self-reported drinking or to highly correlate with the actual BrAC measures (b = 0.90 to 0.91). Conclusions: Transdermal alcohol monitors offer an opportunity to measure alcohol consumption in a valid and continuous way with mathematical models and software estimating BrAC values improving interpretation of TAC data. However, the SCRAM seems unable to detect low-to-moderate drinking levels using the thresholds and criteria set by the manufacturer. Moreover, the WrisTAS and the Skyn prototype show a high failure rate, raising questions about reliability. Future studies will assess the validity of new-generation wristbands, including the next Skyn generations.

show abstract

mentioning

confidence: 99%

Wearable Transdermal Alcohol Monitors: A Systematic Review of Detection Validity, and Relationship Between Transdermal and Breath Alcohol Concentration and Influencing Factors

Egmond

Wright

Livingston

et al. 2020

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…Colorimetric‐based epidermal microfluidic systems provide insights about sweat concentrations and dynamics at discrete points in time; but this class of biochemical sensor does not provide continuous tracking. Electrochemical sensors constitute a powerful measurement tool for measuring electrolytes, metabolites, and protein targets . Biochemical data captured and transmitted, in digital formats, by wireless wearable electrochemical sensors establish high resolution tracking of metabolic activity and physiological status in remote environments .…”

Section: Epidermal Electrochemical Sensing Systemsmentioning

confidence: 99%

Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

Ghaffari

Choi

Raj

et al. 2019

Adv Funct Materials

116

View full text Add to dashboard Cite

Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin‐interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real‐time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully‐integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real‐time physiological insights.

show abstract

“…Other wearable biosensors for ethanol were described, enabling real-time, continuous, and fast detection, with a similar performance to that mentioned above [36,37]. For example, a wearable tattoo-based biosensing system was developed by Kim et al [38] for noninvasive alcohol monitoring in induced sweat.…”

Section: Organic Toxics: Alcoholmentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

View full text Add to dashboard Cite

This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods capable of detecting very small concentrations of analytes and provide selective determinations through analytical responses, without significant interferences from other components of the samples, are presented and discussed, thus stressing the great versatility and utility of electrochemical biosensors in this growing research field. To illustrate this, the determination of substances with forensic relevance by using electrochemical biosensors reported in the last five years (2015–2019) are reviewed. The different configurations of enzyme or affinity biosensors used to solve analytical problems related to forensic practice, with special attention to applications in complex samples, are considered. Main prospects, challenges to focus, such as the fabrication of devices for rapid analysis of target analytes directly on-site at the crime scene, or their widespread use and successful applications to complex samples of interest in forensic analysis, and future efforts, are also briefly discussed.

show abstract

Wearable electrochemical alcohol biosensors

Cited by 110 publications

References 56 publications

Wearable Transdermal Alcohol Monitors: A Systematic Review of Detection Validity, and Relationship Between Transdermal and Breath Alcohol Concentration and Influencing Factors

Wearable Transdermal Alcohol Monitors: A Systematic Review of Detection Validity, and Relationship Between Transdermal and Breath Alcohol Concentration and Influencing Factors

Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

Contact Info

Product

Resources

About