Wearable devices: underrepresentation in the ageing society

Guu, Ta-Wei; Muurling, Marijn; Khan, Zunera; Kalafatis, Chris; Aarsland, Dag; Ffytche, Dominic; Brem, Anna-Katharine

doi:10.1016/s2589-7500(23)00069-9

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…Study participants with cognitive function in the normal to mild dementia range have overall good compliance. 10 , 28 However, studies including participants with mild to moderate dementia found compliance decreased with participants’ cognitive ability, 29 , 30 which is contrary to our finding that participants with the worst cognitive function as indicated by FAST score had better compliance. The marginal sex difference found in our study may partly explain the contradictory results as the two female participants with the worst compliance had better functionality/cognition (FAST score 6a and 6d, respectively).…”

Section: Discussioncontrasting

confidence: 99%

“…First, our participants only needed to wear the device passively. As poor cognitive function may impair acceptance and compliance in studies with more complex protocols, 29 , 30 our results may not be generalizable to studies involving greater device‐related cognitive demands (e.g., remembering to press buttons or record data). Also, this study was done within the STAND trial, which tested the feasibility of using Sativex to reduce agitation in late‐stage dementia so that watch acceptance and compliance might be contaminated by the effect of the investigational product.…”

Section: Discussionmentioning

confidence: 83%

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Wrist‐worn actigraphy in agitated late‐stage dementia patients: A feasibility study on digital inclusion

Guu,

Brem,

Albertyn

et al. 2024

Alzheimer's & Dementia

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BACKGROUNDWrist‐worn actigraphy can be an objective tool to assess sleep and other behavioral and psychological symptoms in dementia (BPSD). We investigated the feasibility of using wearable actigraphy in agitated late‐stage dementia patients.METHODSAgitated, late‐stage Alzheimer's dementia care home residents in Greater London area (n = 29; 14 females, mean age ± SD: 80.8 ± 8.2; 93.1% White) were recruited to wear an actigraphy watch for 4 weeks. Wearing time was extracted to evaluate compliance, and factors influencing compliance were explored.RESULTSA high watch‐acceptance (96.6%) and compliance rate (88.0%) was noted. Non‐compliance was not associated with age or BPSD symptomatology. However, participants with “better” cognitive function (R = 0.42, p = 0.022) and during nightshift (F1.240, 33.475 = 8.075, p = 0.005) were less compliant. Female participants were also marginally less compliant (F1, 26 = 3.790, p = 0.062).DISCUSSIONSWrist‐worn actigraphy appears acceptable and feasible in late‐stage agitated dementia patients. Accommodating the needs of both the patients and their carers may further improve compliance.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 83%

Wrist‐worn actigraphy in agitated late‐stage dementia patients: A feasibility study on digital inclusion

Guu,

Brem,

Albertyn

et al. 2024

Alzheimer's & Dementia

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“…Digital biomarkers, including metrics derived from physical activity and function (movement), represent real-life data, such as high-frequency observational data, some of which are incomplete and possibly biased and still need to be subjected to more accurate validation procedures [ 2 ]. In addition, studies examining the use of wearable devices have limited applicability to the elderly because they are often underrepresented in the patient population [ 99 ]. Future prospective cross-sectional studies need to further investigate the use of wearables in orthopedic trauma surgery with regard to their promising perspectives in individual patient diagnosis and therapy.…”

Section: A Final Thoughtmentioning

confidence: 99%

Wearable Sensors in Other Medical Domains with Application Potential for Orthopedic Trauma Surgery—A Narrative Review

Vogel,

Grimm,

Marmor

et al. 2024

JCM

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The use of wearable technology is steadily increasing. In orthopedic trauma surgery, where the musculoskeletal system is directly affected, focus has been directed towards assessing aspects of physical functioning, activity behavior, and mobility/disability. This includes sensors and algorithms to monitor real-world walking speed, daily step counts, ground reaction forces, or range of motion. Several specific reviews have focused on this domain. In other medical fields, wearable sensors and algorithms to monitor digital biometrics have been used with a focus on domain-specific health aspects such as heart rate, sleep, blood oxygen saturation, or fall risk. This review explores the most common clinical and research use cases of wearable sensors in other medical domains and, from it, derives suggestions for the meaningful transfer and application in an orthopedic trauma context.

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“…It becomes increasingly important to consider the feasibility, acceptance, usability, and ecological validity of digital endpoints in real-world settings. Few studies report on these factors and ageing populations are not well represented in RMT research ( 22 ), but are explored in RADAR-AD, IDEA-FAST and Mobilise-D in collaboration with patients and carers. In studies involving wearables and smartphone apps, acceptance to use devices and adherence to protocol are in general positive when they are reported ( 23 , 24 ).…”

Section: Feasibility Acceptability and Usability Of Digital Assessmentsmentioning

confidence: 99%

Digital endpoints in clinical trials of Alzheimer’s disease and other neurodegenerative diseases: challenges and opportunities

et al. 2023

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Alzheimer’s disease (AD) and other neurodegenerative diseases such as Parkinson’s disease (PD) and Huntington’s disease (HD) are associated with progressive cognitive, motor, affective and consequently functional decline considerably affecting Activities of Daily Living (ADL) and quality of life. Standard assessments, such as questionnaires and interviews, cognitive testing, and mobility assessments, lack sensitivity, especially in early stages of neurodegenerative diseases and in the disease progression, and have therefore a limited utility as outcome measurements in clinical trials. Major advances in the last decade in digital technologies have opened a window of opportunity to introduce digital endpoints into clinical trials that can reform the assessment and tracking of neurodegenerative symptoms. The Innovative Health Initiative (IMI)-funded projects RADAR-AD (Remote assessment of disease and relapse—Alzheimer’s disease), IDEA-FAST (Identifying digital endpoints to assess fatigue, sleep and ADL in neurodegenerative disorders and immune-mediated inflammatory diseases) and Mobilise-D (Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement) aim to identify digital endpoints relevant for neurodegenerative diseases that provide reliable, objective, and sensitive evaluation of disability and health-related quality of life. In this article, we will draw from the findings and experiences of the different IMI projects in discussing (1) the value of remote technologies to assess neurodegenerative diseases; (2) feasibility, acceptability and usability of digital assessments; (3) challenges related to the use of digital tools; (4) public involvement and the implementation of patient advisory boards; (5) regulatory learnings; and (6) the significance of inter-project exchange and data- and algorithm-sharing.

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Wearable devices: underrepresentation in the ageing society

Cited by 8 publications

References 11 publications

Wrist‐worn actigraphy in agitated late‐stage dementia patients: A feasibility study on digital inclusion

Wrist‐worn actigraphy in agitated late‐stage dementia patients: A feasibility study on digital inclusion

Wearable Sensors in Other Medical Domains with Application Potential for Orthopedic Trauma Surgery—A Narrative Review

Digital endpoints in clinical trials of Alzheimer’s disease and other neurodegenerative diseases: challenges and opportunities

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