“…1,9 The primary experimental difficulty in the in vivo tribological investigation of fabrication process on wear and implant performance, however, is the regulation and measurement of in vivo testing conditions; namely: surgical implantation and alignment, patient loading and activity, and the influence of implant design on wear and performance. Studies of retrieved implants that evaluate wear based on visual examination of surface damage, 10,11,14 dimensional and contour changes, 15 subsurface analysis, 3,10 surface area of damage on the implant, 10,15,16 and/or changes in surface morphology, 13,15 have established modes of wear and material damage in vivo. Because of the lack of knowledge of in vivo loading conditions, these retrieval analyses reveal little about the kinematic performance and wear rate over time.…”