This article addresses the challenges involved with transitioning a pain practice away from chronic opioid management. The best approach is to avoid long term opioid therapy (LTOT) when possible and taper off opioids where appropriate. The management of patients with opioid use is complex with psychiatric comorbidities and poor coping skills often impeding opioid cessation. A multidisciplinary approach with frequent involvement is the most effective approach for dose reduction and discontinuation.