Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation

Kyriakoudi, Anna; Rovina, Nikoletta; Koltsida, Ourania; Kostakou, Eirini; Konstantelou, Elissavet; Kardara, Matina; Kompoti, Maria; Palamidas, Anastasios; Kaltsakas, Georgios; Koutsoukou, Antonia

doi:10.3390/diagnostics12010092

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…In a sub-group of patients, we measured both IL-18BP and IL-1R4: the two molecules were mildly increased in patients compared to healthy controls (data not shown). Although an increasing trend was seen from non-sepsis to sepsis and shock patients, IL-18BP and IL-1R4 were not significantly associated with mortality, in contrast to what reported by others ( 93 , 96 – 98 ). A future comprehensive analysis of all the different molecules belonging to the IL-1 pathway would be helpful to fully define the strength of this essential family of inflammatory mediators in assessing sepsis patients.…”

Section: Discussioncontrasting

confidence: 97%

A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

et al. 2022

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Background: Early prognostic stratification of patients with sepsis is a difficult clinical challenge. Aim of this study was to evaluate novel molecules in association with clinical parameters as predictors of 90-days mortality in patients admitted with sepsis at Humanitas Research Hospital.Methods: Plasma samples were collected from 178 patients, diagnosed based on Sepsis-3 criteria, at admission to the Emergency Department and after 5 days of hospitalization. Levels of pentraxin 3 (PTX3), soluble IL-1 type 2 receptor (sIL-1R2), and of a panel of pro-and anti-inflammatory cytokines were measured by ELISA. Cox proportional-hazard models were used to evaluate predictors of 90-days mortality.

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Section: Discussioncontrasting

confidence: 97%

A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

et al. 2022

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“…Е. Yagmur et al investigated for the first time the possible role of clusterin as a prognostic biomarker in critically ill patients hospitalized in the intensive care unit, with or without sepsis [28]. It is interesting that A. Kyriakoudi et al evaluated the possible role of IL-18 and its binding to IL-18BP protein as a biomarker of patients with sepsis [21]. Programmed death protein (PD-1) is another inflammatory marker proposed as a diagnostic and prognostic tool of sepsis [24].…”

Section: оригінальні дослідженняmentioning

confidence: 99%

Modern methods of the diagnostic of pathology of pregnancy and the postpartum period

Bulavenko,

Ostapiuk,

Rud

et al. 2023

UJPP

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Postpartum purulent-inflammatory diseases are currently a serious problem. Purpose - to develop and implement of a new modern method of the diagnosis, monitoring and assessment of health of women during pregnancy, before childbirth and in the postpartum period - the method of fluorescence spectroscopy - to ensure the provision of highly qualified medical care, including the effective treatment. Materials and methods. The research material consisted of blood serum samples of 265 patients. There were 40 pregnant women (the Group 1), 40 women with an uncomplicated postpartum period (the Group 2), 170 - with postpartum purulent-inflammatory diseases (the Group 3), 15 patients with sepsis (the Group 4). Diagnostic methods: clinical, laboratory, instrumental, method of fluorescence spectroscopy, statistical (logistic regression and ROC analysis methods). Results. In the Group 1 there is an increase in the intensity of fluorescence to 1.3 r.u. For the Group 2 the intensity of fluorescence was within 0.86-1.0 r.u. For the Group 3, the decrease in fluorescence intensity from 1 to 0.35 r.u. was recorded. For the Group 4 in addition to decreasing the fluorescence intensity, a noticeable shift of the fluorescence spectra of blood serum into the long-wave range was recorded. Conclusions. A reliable prognostic model of the development of postpartum purulent-inflammatory diseases was created. The modern approach for the diagnosis and effective control of treatment within the framework of the method of fluorescent spectroscopy and biomarkers using infusions of donor albumin solutions is proposed. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.

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“… 5 In the past decade, researchers have verified that conventional cell blood count (CBC) parameters are effective biomarkers for the screening of septicemia. 6 Besides, emerging biological markers such as pentraxin-3 (PTX3), 7 clusterin, 8 IL-18, 9 and circRNA-miRNA-lncRNA networks 10 can also be used to obtain prognostic information on patients with sepsis, thereby providing guidance and monitoring for relevant treatment. Heparin-binding protein (HBP) is a novel biomarker related to infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

The Predictive Value of Heparin-Binding Protein and D-Dimer in Patients with Sepsis

Tang¹,

Yuan²,

Wu³

et al. 2023

IJGM

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Objective To explore the serial measurement of heparin-binding protein and D-dimer in the prediction of 28-day mortality and efficacy evaluation of critically-ill patients with sepsis. Methods We recruited a total of 51 patients with sepsis in the ICU of our hospital. They were divided into a survival group or a death group according to their prognosis 28 days after treatment. The HBP and D-dimer levels in these patients were determined on the 1st (24h), 3rd, and 5th days. Besides, the sequential organ failure assessment (SOFA) score of these patients was recorded at admission. The patients in both groups were subjected to comparison regarding HBP and D-dimer levels and SOFA scores within 24h of admission. Additionally, a correlation between the levels of HBP and D-dimer and the SOFA score was statistically measured, while the predictive effectiveness of these factors for the prognosis of patients with sepsis was also determined. Moreover, the dynamic changes in HBP and D-dimer during the treatment of both groups were analyzed. Results The HBP and D-dimer levels and the SOFA scores in the survival group were considerably lower than those in the death group, and the differences were statistically significant ( P <0.05). Additionally, the levels of HBP and D-dimer in sepsis patients were positively correlated with the SOFA score ( P <0.05). The area under the curve (AUC) of HBP, D-dimer, and their combination in predicting the prognosis of patients with sepsis was 0.824, 0.771, and 0.830, respectively. Besides, the sensitivity and specificity of their combination in predicting the prognosis of patients with sepsis were 68.42% and 92.31%, respectively. The HBP and D-dimer levels presented a downward trend in the survival group during treatment, while they exhibited an upward trend in the death group. Conclusion HBP and D-dimer realize high predictive effectiveness for the prognosis of patients with sepsis, while the combined use of these two factors achieves superior effectiveness. Thus, they can be applied to the prediction of 28-day mortality and efficacy evaluation of sepsis patients.

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Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation

Cited by 5 publications

References 40 publications

A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

Modern methods of the diagnostic of pathology of pregnancy and the postpartum period

The Predictive Value of Heparin-Binding Protein and D-Dimer in Patients with Sepsis

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