Weakly aligned Ti3C2TxMXene liquid crystals: measuring residual dipolar coupling in multiple co-solvent systems

Zhao, You; Qin, Huan; Yang, Yong; Li, Jia-Qian; Qin, Si‐Yong; Zhang, Aiqing; Lei, Xinxiang

doi:10.1039/d3nr00204g

Cited by 5 publications

(7 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To quantitatively measure the difference in the orientation of artemether in these different media, β angle, an NMR parameter that can be exploited to evaluate the orientation difference in the alignment tensors of a certain solute in two different media systems − and quantify the enantiodiscriminating property of a certain alignment medium to enantiomers, , was introduced here. In general, a β angle of 0° means the same orientation of a targeted analyte in two kinds of media, whereas a β angle of 90° suggests orthogonal alignment tensors caused by two different media.…”

Section: Resultsmentioning

confidence: 99%

Programming Peptide Liquid Crystal Media to Acquire Independent Sets of Residual Dipolar Couplings and Enantiodiscrimination in Multiple Solvent Systems

Qin,

He,

Zhao

et al. 2023

Anal. Chem.

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Programming Peptide Liquid Crystal Media to Acquire Independent Sets of Residual Dipolar Couplings and Enantiodiscrimination in Multiple Solvent Systems

Qin,

He,

Zhao

et al. 2023

Anal. Chem.

Self Cite

View full text Add to dashboard Cite

“…Their study highlighted the influence of the aspect ratio of MXene flakes on the formation of these types of phases. The self-aligning capability of MXene-based dispersions in the presence of socalled co-solvents (CH 3 OH-H 2 O, DMSO-H 2 O, DMF-H 2 O, and acetone-H 2 O) has also been studied in-depth and reported previously [6]. Utilization of MXenes for the development of LC phases has also been successfully reported previously by Usman et al [7] who demonstrated the importance of adding cellulose nanocrystals in MXene-based dispersions for facilitating the formation of various LC phases.…”

Section: Introductionmentioning

confidence: 83%

Dielectric anisotropy in self-assembling MXene-based lyotropic nematic compounds

Olariu,

Vlad-Bubulac,

Filip

et al. 2024

J. Phys. D: Appl. Phys.

View full text Add to dashboard Cite

Formation of lyotropic liquid crystal (LC) phase at the level of MXene aqueous dispersions as of self-assembling capacity has been previously successfully reported. However, the influence of electrical external factors was less studied in spite of the fact that understanding the electrical behaviour of 2D based liquid crystal compounds is vital for fostering the development of new innovative applications. Consequently, within the herein paper we are reporting an in-depth evaluation of dielectric properties of liquid crystalline phases in Ti3C2 Mxene aqueous dispersions. Dependence on low voltage of planner ′⟘ to homeotropic ′ǁ orientational transition is emphasized and discussed while the influence of electric field frequency at the level of dielectric anisotropy is assessed in respect to various concentrations of Mxene flakes within the same 2D based compounds. Nonetheless, dielectric spectroscopy highlighted the biphasic nature (containing both nematic and isotopic phases) of the studied aqueous Ti3C2 Mxene inks visible up to 20% Mxene. Above this concentration, pure nematic phase existence in dispersion of high Mxene concentration (>20 wt%) was detected based on evaluation of dielectric permittivity against various voltage values.

show abstract

“…D 2 O-bearing Ti 3 C 2 T x LC medium was obtained from the lyophilized Ti 3 C 2 T x solid after ultrasound-assisted redispersion in D 2 O (Figure 2H). 25 2I). Moreover, these media actualized the accurate RDC acquisition on aromatic analytes such as Boc-D-tryptophan and estrone that were incompatible with unmodified GO media.…”

Section: Mxene Lcmentioning

confidence: 98%

“…(I) [ 1 H, 13 C]-CLIP-HSQC spectra of (+)-IPC obtained in the isotropic DMSO- d 6 /D 2 O solution (red) and anisotropic Ti 3 C 2 T x LC in DMSO- d 6 /D 2 O (blue). Adapted with permission from ref . Copyright 2023 Royal Society of Chemistry.…”

Section: D Colloidal Llc Mediamentioning

confidence: 99%

“…To improve the dispersion of Ti 3 C 2 T x nanosheet in organic solvents, we extended the etching time toward Ti 3 AlC 2 , to obtain Ti 3 C 2 T x nanoflakes with smaller sizes. D 2 O-bearing Ti 3 C 2 T x LC medium was obtained from the lyophilized Ti 3 C 2 T x solid after ultrasound-assisted redispersion in D 2 O (Figure H) . Following this, organic deuterated reagents were added into D 2 O-bearing Ti 3 C 2 T x LC, and alignment media in cosolvents of DMSO- d 6 –D 2 O, CD 3 OD–D 2 O, DMF- d 7 –D 2 O, and (CD 3 ) 2 CO–D 2 O were established.…”

Section: D Colloidal Llc Mediamentioning

confidence: 99%

See 1 more Smart Citation

Weak Alignment Liquid Crystal Media from Colloidal Dispersion and Self-assembled Oligopeptide for Anisotropic NMR

Qin,

Zhao,

et al. 2024

Acc. Mater. Res.

Self Cite

View full text Add to dashboard Cite

Metrics & MoreArticle Recommendations * sı Supporting Information CONSPECTUS: Acquiring anisotropic NMR parameters such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs) has been demonstrated as a powerful route to elucidate the three-dimensional structure of organic molecules in organic and medicinal chemistry. However, this methodology is somewhat compromised by the limited availability of alignment media, which are indispensable to induce the partial orientation of analytes for anisotropic data acquisition. Given the feature of inherent anisotropy, lyotropic liquid crystals (LLCs) have been documented as excellent candidates to act as alignment media. This Account aims to review the research progress of developing LLCs to obtain anisotropic NMR data. We mainly focus on two complementary LC media, i.e., two-dimensional (2D) colloidal dispersions and self-assembled peptides, that are generated by a "top-down" approach and "bottom-up" approach, respectively. Our laboratory has been at the forefront of developing 2D colloidal dispersions as alignment media. We first demonstrated the applicability of graphene oxide (GO) LLCs in the RDC-based structural elucidation of small molecules. When used as alignment media, GO LLCs showed a striking feature of no background signals. Clean NMR spectra enable accurate data assignment without disturbances and even effective RDC measurements of rare natural products. To circumvent the limitation that preparing GO LLC media needs tedious solvent exchange to remove nondeuterated solvents for NMR experiments, we subsequently developed MXene LLCs. Different from GO media whose anisotropy would be destroyed after direct freeze-drying, MXene can self-align in the redispersed solution to recover LC behavior. This feature provides great convenience for sample preservation and rapid medium preparation. Another advantage of MXene LLCs over GO media is the applicability to directly measure RDCs of aromatic solutes with no need for chemical modification on MXenes.To complement the 2D colloidal media that are only compatible with strong polar solvents, we further develop supramolecular LLCs. Oligopeptides, due to their mature synthesis strategy, structural designability, and robust self-assembly ability, have been exploited to create supramolecular alignment media in different solvents. We first reported CH 3 OH-, DMSO-, and multiple solventcompatible peptide media, which show the broad applicability of their corresponding analytes. Meanwhile, the chiral amino acids confer oligopeptide LLCs with potential chirality, and we have demonstrated their relative application of enantiodiscrimination.Arising from the structural diversity of oligopeptides, several distinct LLC media are constructed and applied to measure independent sets of RDCs. This offers an opportunity for de novo structural determination of organic molecules.In light of the good fluidity of these media, analytes can rapidly penetrate the LLC phases for self-alignment, facilitating simple and fas...

show abstract

Weakly aligned Ti₃C₂T_xMXene liquid crystals: measuring residual dipolar coupling in multiple co-solvent systems

Abstract: Residual Dipolar Couplings (RDCs), acquired relying on weakly alignment media, are highly valuable for the structural elucidation of organic molecules. Arising from the striking features of no background signal and...

Cited by 5 publications

References 49 publications

Programming Peptide Liquid Crystal Media to Acquire Independent Sets of Residual Dipolar Couplings and Enantiodiscrimination in Multiple Solvent Systems

Programming Peptide Liquid Crystal Media to Acquire Independent Sets of Residual Dipolar Couplings and Enantiodiscrimination in Multiple Solvent Systems

Dielectric anisotropy in self-assembling MXene-based lyotropic nematic compounds

Weak Alignment Liquid Crystal Media from Colloidal Dispersion and Self-assembled Oligopeptide for Anisotropic NMR

Contact Info

Product

Resources

About