Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity

Hatfield, Steven; Daniels, Keith A.; O’Donnell, Carey L.; Waggoner, Stephen N.; Welsh, Raymond M.

doi:10.1016/j.virol.2018.04.012

Cited by 15 publications

(27 citation statements)

References 83 publications

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“…*CD3 and CD20 (Т-and В-cells markers) are absent in NK-cells. *CD11b-CD27+; CD11b-CD27+ are markers that show a weakened differentiation (immaturity) of NK-cells [19].…”

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

“…Cytotoxic factors of NK-populations As phenotypes are transformed into relevant cytotoxic cells populations, granzymes A, B, and K, perforin, and other anti-tumor agents are released in the process [6,19,23]. These factors are in systemic contrast with scattered tumor factors (lactate dehydrogenase, TGF-beta, CSF1, some others) [8, 37,40].…”

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

“…NK-populations with anti-tumor / anti-viral activities (the order: NK-populations; tumor targets linked to viruses; effects produced by NKpopulations) *NKG2A+CD56bright; "humanized" mice B-cell lymphoma; IFN-gamma release by the population, cooperation with NKp44-receptors in order to inhibit В-cell transformation linked to EBV [22]. *NKG2A+; when VACV is present, populations are expressed more strongly [19]. *NKG2A+KIR−; set a limit to lytic EBVreplication [28].…”

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

“…But at the same time researchers are paying greater attention to cell populations of in-born immunity [1,15,19,27]. Thus, NK (natural killers)-cell populations (hereinafter called NK-populations) play a significant role as regards developing anti-body immunity in children [6,26].…”

mentioning

confidence: 99%

“…Viruses and tumors considered in relation to them. Viruses that are examined in the aspect under consideration include the following: arenaviruses (lymphocytic choriomeningitis virus, LCMV), herpes viruses (cytomegalovirus, CMV), in relation to acute leukemia and В-cell lymphomas; co-infections with other viruses; Epstein-Barr virus, EBV, in relation to mononucleosis, Burkitt lymphomas; vaginal herpes viruses [7,28,34]); papovaviruses (human papillomavirus, HPV, in relation to cervical cancer); pox viruses (cattle pox virus, mice pox virus, vaccinavirus or orthopoxvirus, VACV) [19,27]; retroviruses (human immunodeficiency virus, HIV, including co-infection with CMV; in relation to lymphomas); flaviviruses (hepatitis-С virus, HCV; in relation to hepatocellular carcinomas HCC); hepatitis-В virus [HBV] and hepatitis delta virus [HDV]) [25]; togaviruses (chikungunya virus; in relation to sarcomas) [24].…”

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confidence: 99%

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NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections

Lakhtin¹,

Lakhtin²,

Алешкин³

et al. 2019

Health Risk Analysis

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Risks related to tumors development against a background of viral infections as well as factors that determine such risks or reduce them have not been examined profoundly so far. Our research goal was to accomplish a scientific review of research on a potential possessed by populations of lectin NK-cells (natural killers) in a body; such populations can have variable sets of lectin and other functionally significant cell surface receptors against tumors in a situation when viruses, including epidemically significant ones, penetrate a body. It is shown that cofunctioning of various receptors and their ligands that redistribute cytokines (glycopattern-identifying lectin (basis) receptors, Ig-similar receptors, cytotoxic receptors, and other effector (adjusting) receptors) plays a significant role in intercellular communications and effects produced by NK-populations. NK-populations network is a promising resource for body protection and it should be taken into account when developing new anti-tumor and anti-viralpreventive and medical strategies. When certain NK-populations with protective functions are absent in a body, it can be considered a new multi-factor risk of viral and oncologic diseases in an individual or a contingent living in a specific region. The reviewed data can be applied to develop new anti-tumor and anti-viral medications and vaccines as well as medical strategies. Probiotic lectins are promising ligands of intercellular communications associated with immune surveillance. Read online __________________________  Lakhtin M.V.

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“…*CD3 and CD20 (Т-and В-cells markers) are absent in NK-cells. *CD11b-CD27+; CD11b-CD27+ are markers that show a weakened differentiation (immaturity) of NK-cells [19].…”

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections

Lakhtin¹,

Lakhtin²,

Алешкин³

et al. 2019

Health Risk Analysis

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Regulation of the human NK cell compartment by pathogens and vaccines

Goodier

Riley

2021

Clin & Trans Imm

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Natural killer cells constitute a phenotypically diverse population of innate lymphoid cells with a broad functional spectrum. Classically defined as cytotoxic lymphocytes with the capacity to eliminate cells lacking self-MHC or expressing markers of stress or neoplastic transformation, critical roles for NK cells in immunity to infection in the regulation of immune responses and as vaccineinduced effector cells have also emerged. A crucial feature of NK cell biology is their capacity to integrate signals from pathogen-, tumor-or stress-induced innate pathways and from antigenspecific immune responses. The extent to which innate and acquired immune mediators influence NK cell effector function is influenced by the maturation and differentiation state of the NK cell compartment; moreover, NK cell differentiation is driven in part by exposure to infection. Pathogens can thus mould the NK cell response to maximise their own success and/or minimise the damage they cause. Here, we review recent evidence that pathogen-and vaccine-derived signals influence the differentiation, adaptation and subsequent effector function of human NK cells.

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Regulatory functions of NK cells during infections and cancer

Zwirner

Domaica

Fuertes

2020

Journal of Leukocyte Biology

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After recognition, NK cells can kill susceptible target cells through perforin-dependent mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete cytokines that are pivotal for immunomodulation. Despite the critical role as effector cells against tumors and virus-infected cells, NK cells have been implicated in the regulation of T cell-mediated responses in different models of autoimmunity, transplantation, and viral infections. Here, we review the mechanisms described for NK cell-mediated inhibition of adaptive immune responses, with spotlight on the emerging evidence of their regulatory role that shapes antitumor immune responses.

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Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity

Cited by 15 publications

References 83 publications

NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections

NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections

Regulation of the human NK cell compartment by pathogens and vaccines

Regulatory functions of NK cells during infections and cancer

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