A Maxwell-Stefan system for fluid mixtures with driving forces depending on Cahn-Hilliard-type chemical potentials is analyzed. The corresponding parabolic crossdiffusion equations contain fourth-order derivatives and are considered in a bounded domain with no-flux boundary conditions. The main difficulty of the analysis is the degeneracy of the diffusion matrix, which is overcome by proving the positive definiteness of the matrix on a subspace and using the Bott-Duffin matrix inverse. The global existence of weak solutions and a weak-strong uniqueness property are shown by a careful combination of (relative) energy and entropy estimates, yielding H 2 (Ω) bounds for the densities, which cannot be obtained from the energy or entropy inequalities alone.