Weak magnetic fields alter stem cell–mediated growth

Huizen, Alanna V. Van; Morton, Jacob M.; Kinsey, Luke J.; Kannon, Donald G. Von; Saad, Marwa A. Hasby; Birkholz, Taylor R.; Czajka, Jordan M.; Cyrus, Julian; Barnes, Frank S.; Beane, Wendy S.

doi:10.1126/sciadv.aau7201

Cited by 96 publications

(112 citation statements)

References 39 publications

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“…Magnetic fields can modify the chemical reaction rates that involve conversions of molecules such as O 2 to O 2 −• , affect other reactions that occur downstream in the metabolic processes, including the release of Ca ++ ions, H 2 O 2 , and NO, and change membrane potentials [Gurhan et al, 2020; Van Huizen et al, 2019]. Blank and Soo [1998] show that magnetic fields in the range from 3 to 6 µT accelerate the oxidation of cytochrome c at 60 Hz.…”

Section: Discussionmentioning

confidence: 99%

“…These are linked to changes in membrane potentials that can either inhibit or accelerate the firing rate of pacemaker or clock cells. Other references using static and/or alternating fields that show changes in reactive oxygen species include Novikov et al [2015, 2019]; Poniedzialek et al [2012]; Ponomarev and Novikov [2009]; Van Huizen et al [2019].…”

Section: Discussionmentioning

confidence: 99%

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Possible Mechanism for Synchronized Detection of Weak Magnetic Fields by Nerve Cells

Barnes

Greenebaum

2020

Bioelectromagnetics

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We propose that biological systems may detect static and slowly varying magnetic fields by the modification of the timing of firing of adjacent nerve cells through the local influence of the magnetic field generated by current from one cell's firing on its nearest neighbors. The time delay of an adjacent nerve cell pulse with respect to the initial clock nerve cell pulse could serve as a signal for sensing the magnitude and direction of the magnetic field in a direction perpendicular to the current flows in the cells. It has been shown that changes in static magnetic fields modify concentrations of reactive oxygen species, calcium, pH, the growth rates of fibrosarcoma cells, and membrane potentials. These are linked to changes in membrane potentials that can either inhibit or accelerate the firing rate of pacemaker or clock cells. This mechanism may have applications to animals' use of magnetic fields for navigation or other purposes, possibly in conjunction with other mechanisms. Bioelectromagnetics. © 2020 Bioelectromagnetics Society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Possible Mechanism for Synchronized Detection of Weak Magnetic Fields by Nerve Cells

Barnes

Greenebaum

2020

Bioelectromagnetics

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“…Additionally, recent computational work suggests that [FAD˙−-HO 2˙] or [FADH˙-O 2˙− ] can be alternative radical pairs at the origin of magnetoreception in Crys (Mondal and Huix-Rotllant, 2019), and ROS levels have also been shown to be sensitive to the changes in magnetic field intensity (Sherrard et al, 2018;Van Huizen et al, 2019). Moreover, it is well documented that ROS are critical in the regulation of energy metabolism and food intake due to their versatile roles in mediating the expression of vertebrate NPY (homolog of invertebrate NPF), glucose levels (Drougard et al, 2015) as well as the AKH/AKHR pathway (Kodrik et al, 2015).…”

Section: Glucose Levels Of 5th Instar Nymphsmentioning

confidence: 99%

“…Although there may be the need for human beings to understand how organisms from Earth might perform during space travel where the field is ~10,000 times weaker than that of Earth's (Mallis and DeRoshia, 2005), the NZMF can also be taken as a sham control for the study of specific magnetoreception mechanisms (Fedele et al, 2014;Heyers et al, 2010). Indeed, organismal studies that impose a NZMF treatment do suggest the importance of GMF in maintaining organism homeostasis (Fedele et al, 2014;Van Huizen et al, 2019;Wan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Body weight is closely related to energy homeostasis in animals, and migratory fuelling which is characterized by gaining body mass and increased food intake during migration has been shown to be affected by GMF information (intensity, direction, or both) (Fransson et al, 2001;Henshaw et al, 2009;Henshaw et al, 2008;Kullberg et al, 2007). Interestingly, recent studies showed field intensity-dependent changes in the production of reactive oxygen species (ROS) which are regarded as signaling molecules for appetite-related neurons (Drougard et al, 2015;Sherrard et al, 2018;Van Huizen et al, 2019). Moreover, magnetic responses of adipokinetic hormone (AKH)/ AKH receptor (AKHR) signaling, reported to be involved in appetite regulation (Gáliková et al, 2017;Lin et al, 2019), was also found in adult rice planthoppers .…”

Section: Introductionmentioning

confidence: 99%

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Geomagnetic field absence reduces adult body weight of a migratory insect by disrupting feeding behavior and appetite regulation

Wan

Jiang

Zhang

et al. 2019

Preprint

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The geomagnetic field (GMF) is well documented for its essential role as a cue used in animal orientation or navigation. Recent evidence indicates that the absence of GMF can trigger stress-like responses such as reduced body weight, as we have previously shown in newly emerged adults of the brown planthopper, Nilaparvata lugens. To test the hypothesis that reduced feeding in the absence of the GMF leads to a decrease of N. lugens body weight, we compared magnetic responses in feeding behavior, glucose levels, and expression of magnetoreception-and appetite-related genes in brown planthopper nymphs exposed to either a near-zero magnetic field (NZMF, i.e., GMF absence) or typical GMF conditions. In addition to observing the expected responses in the expression of the potential magnetosensor cryptochromes, the food intake of 5 th instar nymphs was significantly reduced in insects reared in the absence of GMF. Insects that exhibited reduced feeding reared in the absence of the GMF also had higher glucose levels which is associated with food aversion.Expression patterns of appetite-related neuropeptide genes were also altered in the absence of GMF in a manner consistent with diminishing appetite. These findings support the hypothesis that strong changes in GMF intensity can affect insect feeding behavior and underlying regulatory processes.Our results provide further evidence that magnetoreception and regulatory responses to GMF changes can affect a wide variety of biological processes.

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Weak magnetic fields alter stem cell–mediated growth

Abstract: Weak magnetic fields affect reactive oxygen species levels, stem cell proliferation/differentiation, and new tissue growth.

Cited by 96 publications

References 39 publications

Possible Mechanism for Synchronized Detection of Weak Magnetic Fields by Nerve Cells

Possible Mechanism for Synchronized Detection of Weak Magnetic Fields by Nerve Cells

Geomagnetic field absence reduces adult body weight of a migratory insect by disrupting feeding behavior and appetite regulation

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

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