We need more-nuanced approaches to exploring sex and gender in research

Ritz, Stacey A.; Greaves, Lorraine

doi:10.1038/d41586-024-01204-3

Nature

2024

DOI: 10.1038/d41586-024-01204-3

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We need more-nuanced approaches to exploring sex and gender in research

Stacey A. Ritz,

Lorraine Greaves

Abstract: Some scientists are reluctant to investigate questions about sex and gender, particularly given today's sociopolitical tensions around gender identity. But they should lean in and embrace the complexity.

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Cited by 3 publications

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Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Kolliopoulos,

Tiffany,

Polanek

et al. 2024

Adv Healthcare Materials

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Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due to their multi‐potent potential and ability to generate a pro‐regenerative secretome. While many have reported the influence of matrix environment on MSC osteogenic response, few have investigated the effects of donor and sex. Here, a well‐defined mineralized collagen scaffold is used to study the influence of passage number and donor‐reported sex on MSC proliferation and osteogenic potential. A library of bone marrow and adipose tissue‐derived stem cells from eight donors to examine donor viability in osteogenic capacity in mineralized collagen scaffolds is obtained. MSCs displayed reduced proliferative capacity as a function of passage duration. Further, MSCs showed significant sex‐associated variability in osteogenic capacity. Notably, MSCs from male donors displayed significantly higher cell proliferation while MSCs from female donors displayed significantly higher osteogenic response via increased alkaline phosphate activity, osteoprotegerin release, and mineral formation in vitro. The study highlights the essentiality of including donor‐reported sex as an experimental variable and reporting culture expansion in future studies of biomaterial regenerative potential.

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Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Kolliopoulos,

Tiffany,

Polanek

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

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Sex/gender diversity and behavioral neuroendocrinology in the 21st century

Casto,

Maney

2024

Hormones and Behavior

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Ignorance Is Bliss: Anti-Queer Biopolitical Discourse as Conscious Unwillingness to Elaborate Complex Information

Abondio

2024

Humans

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Contemporary biopolitical discourse around fundamental rights and societal representations has increasingly weaponized moral-based attitudes and personal feelings, eschewing informed, factual opinions grounded in observation, data analysis, and scientific research. This trend is evident in the treatment of the queer community—used here as an umbrella term for non-cisgender, non-heterosexual individuals. Over recent years, the group has become the primary target of negationist critiques aimed at undermining the very existence of the community and challenging its rights. This article argues that the rise of depersonalized interactions and individualism, particularly through social media (where superficial and sensationalist content thrives, often at the expense of nuanced, data-driven discourse), the cult of the self and power (which prioritizes individual success, sidelining the collective struggles and rights of marginalized groups), and misinformation, is strategically employed by those in power and reverberated through the general public. These elements serve as a translucent veil, enabling the conscious choice to avoid engaging in structured, complex, and informed discussions about queer people’s rights and their existence. Consequently, the strategic deployment of these tactics, with the aim of shaping public opinion based on falsehoods and emotional appeals, undermines the capacity for informed dialog and perpetuates the marginalization of the queer community.

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We need more-nuanced approaches to exploring sex and gender in research

Abstract: Some scientists are reluctant to investigate questions about sex and gender, particularly given today's sociopolitical tensions around gender identity. But they should lean in and embrace the complexity.

Cited by 3 publications

References 20 publications

Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Sex/gender diversity and behavioral neuroendocrinology in the 21st century

Ignorance Is Bliss: Anti-Queer Biopolitical Discourse as Conscious Unwillingness to Elaborate Complex Information

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