We cannot ignore the real component of the rise in thyroid cancer incidence

Goldenberg, David

doi:10.1002/cncr.32123

Cited by 9 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study refers to the current issues which are discussed in many countries’ healthcare system [ 8 , 28 – 32 ]. The incidence of thyroid cancer has been increasing faster than other cancer because of the prevalence of low risk, non-lethal tumors from detection of a large subclinical reservoir of disease [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring physicians and patients’ perspectives for current interventions on thyroid nodules using a MCDA method

Karrer

Zhang

Kühlein

et al. 2021

Cost Eff Resour Alloc

View full text Add to dashboard Cite

Background The detection of thyroid cancer has rapidly increased over last few decades without an increase in disease specific mortality. Several studies claim that the diagnose of thyroid nodules through routine ultrasound imaging is often the trigger for cascade effects leading to unnecessary follow-up over many years or to invasive treatment. The objective of this study was to explore physicians’ and patients’ insights and preferences regarding the current interventions on thyroid nodules. Methods An online survey was developed using a comprehensive multi-criteria decision analysis (MCDA) framework, the EVIdence based Decision-Making (EVIDEM). The EVIDEM core model used in this study encompassed 13 quantitative criteria and four qualitative criteria. Participants were asked to provide weights referring to what matters most important in general for each criterion, performance scores for appraising the interventions on thyroid nodules and their consideration of impact of contextual criteria. Normalized weights and standardized scores were combined to calculate a value contribution across all participants, additionally differences across physicians and patients’ group were explored. Results 48 patients and 31 physicians were included in the analysis. The value estimate of the interventions on thyroid nodules reached 0.549 for patients’ group and 0.5 was reported by the physicians’ group, compared to 0.543 for all participants. The highest value contributor was ‘Comparative effectiveness’ (0.073 ± 0.020). For the physicians’ group, ‘Comparative safety’ (0.050 ± 0.023) was given with higher value. And for the patients’ group, ‘Type of preventive benefits’ (0.059 ± 0.022) contributed more positively to the value estimation. 51% participants considered ‘Population priorities and access’ having a negative impact on the interventions of nodules.66% participants thought that the ‘system capacity’ had a negative impact. Conclusion Our study shows participants’ preferences on each criterion, i.e., physician indicated keeping the interventions safe and effective more important, patients indicated quality of life after receiving interventions more important. Through comparison among participants, differences have been highlighted, which can make better communication between physicians and patients. This study provides a supportive decision-making for healthcare providers when they explored the interventions on thyroid nodules.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring physicians and patients’ perspectives for current interventions on thyroid nodules using a MCDA method

Karrer

Zhang

Kühlein

et al. 2021

Cost Eff Resour Alloc

View full text Add to dashboard Cite

show abstract

“…This study refers to the current issues which are discussed in many countries' healthcare system [10,11,[13][14][15][16]. The incidence of thyroid cancer has been increasing faster than other cancer because of the prevalence of low risk, non-lethal tumors from detection of a large subclinical reservoir of disease [14].…”

Section: Using Online Platform To Conduct Mcdamentioning

confidence: 99%

Exploring Perspectives and Preferences for Over-Diagnosis and Overtreatment of Thyroid Nodules using a MCDA Method

Karrer

Zhang

Kühlein

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The detection of thyroid cancer has rapidly increased over last few decades without an increase in disease specific mortality. Several studies claim that the diagnose of thyroid nodules through routine ultrasound imaging is often the trigger for cascade effects leading to unnecessary follow-up over many years or to invasive treatment. The objective of this study was to explore physicians’ and patients’ insights and preferences for diagnosis and treatment of thyroid nodules as well as awareness of over-diagnosis and overtreatment. Methods: An online survey was developed using a comprehensive multi criteria decision Analysis (MCDA) framework, the EVIdence based Decision-Making (EVIDEM). The EVIDEM core model used in this study encompassed 13 quantitative criteria and four qualitative criteria. Participants were asked to provide weights for each criterion, performance scores for appraising the thyroid nodules interventions and their consideration of impact of contextual criteria. Normalized weights and standardized scores were combined to calculate a value contribution across all participants, additionally differences across participants were explored. Results: Of all 105 participants, there are 48 patients, 31 physicians and 26 normal citizens. The highest value estimate of the intervention on thyroid nodules reached 0.401 for citizens’ group and lowest value of 0.287 was reported for physicians’ group, compared to 0.359 for all participants. The highest value contributors were efficacy and prevention. Compared to all participants, physicians gave less weight to quality of life and prevention benefits. In addition, physicians’ group gave less score on the treatment such like thyroid surgery compared to other two groups. 59% participants considered healthcare system had a positive impact on the diagnostic of thyroid nodules. Conclusion: Our study shows participants’ preferences on each criterion, i.e., physician indicated keeping the intervention safe and effective more important, patients indicated quality of life after receiving intervention more important. Through comparison among participants, differences have been highlighted, which can make better communication between physicians and patients. This study provided a supportive decision making for health providers when they conduct researches on thyroid nodules.Trial registration: This study did not report the results of a health care intervention on human participants.

show abstract

“…Thyroid cancer (THCA), a frequently-occurring endocrine cancer, takes up approximately 1.7% of human cancers [1]. TC can be divided as 4 subtypes, namely, alloplastic, follicular, medullary and papillary thyroid cancer (PTC) [2].…”

Section: Introductionmentioning

confidence: 99%

m5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in papillary thyroid carcinoma

Deng

Pang

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundRecently, immune response modulation at epigenetic level is illustrated in studies, but it is still unclear about the possible function of RNA 5-methylcytosine (m5C) modification in the cell infiltration within tumor microenvironment (TME).MethodsIn this study, the m5C modification patterns from altogether 493 papillary thyroid carcinoma (PTC) samples were assessed completely according to 9 m5C regulators. Afterwards, the modification patterns were correlated with the cell infiltration features in TME. The m5C modification patterns in tumor samples were quantified through the principal component analysis (PCA) algorithms to establish the m5C-score. Moreover, this study mined the signature genes related to the m5C-score, constructed the PTC diagnostic model by the support vector machine (SVM) method, and verified its accuracy based on samples in TCGA and GEO databases. The effects of 5 potential drugs based on the PTC m5C-score model in PTC cells were investigated through in vitro and in vivo assays (i.e., cell counting kit 8 and xenograft model). ResultsA total of 3 different m5C modification patterns were identified, and high differentiation degree was observed in the cell infiltration features within TME under the above 3 identified patterns. It was revealed that, evaluating m5C modification patterns in single tumor samples helped to estimate the stromal activity in TME, expression of immune checkpoint genes, and prognosis for patients. Typically, a low m5C-score, which was reflected in the activated immunity, predicted the relatively favorable prognostic outcome. Few effective immune infiltration was seen in high m5C-score subtype, indicating the dismal patient survival. Finally, this study constructed a diagnostic model using the 10 signature genes highly related to the m5C-score, discovered that the model exhibited high diagnostic accuracy for PTC, and screened out 5 potential drugs for PTC based on this m5C-score model. ConclusionsAccording to findings in the present study, m5C modification exerts an important part in forming the TME complexity and diversity. It is valuable to evaluate the m5C modification patterns in single tumors, so as to enhance our understanding towards the infiltration characterization in TME and to better guide clinical diagnosis as well as immunotherapies.

show abstract

We cannot ignore the real component of the rise in thyroid cancer incidence

Cited by 9 publications

References 13 publications

Exploring physicians and patients’ perspectives for current interventions on thyroid nodules using a MCDA method

Exploring physicians and patients’ perspectives for current interventions on thyroid nodules using a MCDA method

Exploring Perspectives and Preferences for Over-Diagnosis and Overtreatment of Thyroid Nodules using a MCDA Method

m5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in papillary thyroid carcinoma

Contact Info

Product

Resources

About