We are all aging, and here's why

Abstract

Aging, in simple words, is the gradual decline of an individual organism's health and vitality. Aging, as of yet, is the inevitable side effect of the body's normal functioning. Aging, arguably the most complex human phenotype, is the combined effect of all processes in an organism that leads to a probabilistic increase in the occurrence of disease and eventually death. The characteristics of aging are its complexity and its late-life multimorbidity. The enormous complexity of the aging process is attributed to the large number of interconnected networks of pathways that influence the aging phenotype.Because aging occurs throughout the body of an organism, it leads to a combined loss of efficiency in conventional organ/tissue, such as breakdown of tissue integrity, stem cell dysfunction, and cancer, leading to multimorbidity.So far, research has identified a few independent root causes responsible for the widespread effects of aging and age-associated disease, which comprise cell death or senescence; rapidly dividing cells; cells resistant to death; mitochondrial dysfunction; accumulation of extracellular toxic substances; molecules leading to DNA damage such as oxidizing species (ROS and RNS); and loss of stem cells. The effect of aging and the occurrence of aging-associated diseases in an organism can be considerably brought down by targeting these basic causes.Our body has its own aging mechanism working at a different magnitude, therefore giving a differential contribution to the phenotype of aging. Hence, there is a promising future for personalized medicine to enter and affect the field of aging. Every person can be predisposed to having a higher rate of aging in one system than another (for example, the heart, liver, metabolic system, and immune system).

Selen in der Anti-Aging-Medizin

“…Damit kann man eine integrative Sichtweise auf die Anti-Aging-und Präventionsmedizin etablieren, die sich von den Grundprinzipien der orthomolekularen Medizin ableitet [7,8]. Makronährstoffe liefern im Wesentlichen Energie, und ihr Fehlen macht sich im Körper durch das Hungergefühl bemerkbar.…”