WDR4 promotes HCC pathogenesis through N7-methylguanosine by regulating and interacting with METTL1

Dong, Rui; Wang, Chuanxu; Tang, Bo; Cheng, Yayu; Peng, Xuehui; Yang, Xiaomin; Ni, Bing; Li, Jing

doi:10.1016/j.cellsig.2024.111145

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2024

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Cited by 2 publications

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“…TRMT6/TRMT61A complex inhibitor thiram could suppresses self-renewal of liver CSCs and tumor growth 64 . WDR4 modulates m 7 G modification at the internal sites of tumor-promoting mRNAs by forming the WDR4-METTL1 complex 65 . Upregulation of WDR4-METTL1 promotes lenvatinib resistance in HCC 66 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma

Liu,

Zhou,

Zhao

2024

J. Cancer

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Section: Discussionmentioning

confidence: 99%

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma

Liu,

Zhou,

Zhao

2024

J. Cancer

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METTL Family in Health and Disease

He,

Hao,

Song

et al. 2024

Mol Biomed

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Transcription, RNA splicing, RNA translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, RNA modifications, and protein modifications, play a crucial role in regulating gene expression. The methyltransferase-like protein (METTL) family, a constituent of the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across the cell nucleus, cytoplasm, and mitochondria. Members of the METTL family, through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting processes such as DNA replication, transcription, and mRNA translation, to participate in the maintenance of normal function or promote disease development. This review primarily examines the involvement of the METTL family in normal cell differentiation, the maintenance of mitochondrial function, and its association with tumor formation, the nervous system, and cardiovascular diseases. Notably, the METTL family is intricately linked to cellular translation, particularly in its regulation of translation factors. Members represent important molecules in disease development processes and are associated with patient immunity and tolerance to radiotherapy and chemotherapy. Moreover, future research directions could include the development of drugs or antibodies targeting its structural domains, and utilizing nanomaterials to carry miRNA corresponding to METTL family mRNA. Additionally, the precise mechanisms underlying the interactions between the METTL family and cellular translation factors remain to be clarified.

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WDR4 promotes HCC pathogenesis through N7-methylguanosine by regulating and interacting with METTL1

Cited by 2 publications

References 29 publications

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma

METTL Family in Health and Disease

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WDR4 promotes HCC pathogenesis through N7-methylguanosine by regulating and interacting with METTL1

Cited by 2 publications

References 29 publications

Prognostic signature and immune efficacy of m1A-, m5C-, m6A-, m7G-, and DNA methylation-related regulators in hepatocellular carcinoma

Prognostic signature and immune efficacy of m1A-, m5C-, m6A-, m7G-, and DNA methylation-related regulators in hepatocellular carcinoma

METTL Family in Health and Disease

Contact Info

Product

Resources

About

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma

Prognostic signature and immune efficacy of m¹A-, m⁵C-, m⁶A-, m⁷G-, and DNA methylation-related regulators in hepatocellular carcinoma