Wavesense technology glucometer Linus for routine self-monitoring and clinical practice

Abstract

Conventional glucometer systems for plasma/blood glucose monitoring are based on colorimetry or static electrochemistry using a fixed input signal. The recent glucometer Linus, Wellion, Agamatrix, USA, based on wavesense dynamic electrochemistry, uses a time-varying input signal to give a more accurate glucose reading. The purpose of this study was to compare the plasma glucose (PG) readings obtained by nursing staff from glucometer Linus and PG values estimated on an approved analyzer Daytona™, Randox, Global Medical Instrumentation, Inc., MN, USA. In the course of 5 weeks, 221 fingerprick capillary blood samples were taken from persons with diabetes at different times and investigated using glucometer Linus. Within two following minutes, blood from the same fingerprick was also collected in a tube and centrifuged; the plasma was analyzed on the Daytona™ analyzer. Statistical analysis was performed using the software SPSS v. 15.0, SPSS Inc., Chicago, IL, USA. A total of 221 paired PG values were plotted on the error grid diagram indicating that 218 values (98.6%) of the glucose readings (Linus vs. Daytona) were within the clinically accurate zone A (maximum difference ±20%) and 3 values (1.4%) within the acceptable zone B. Daytona showed 4 PG values <4.2 mmol/l (75 mg/dl) and their difference of respective Linus readings was always <0.83 mmol/l (15 mg/dl). Correlation of results was strong (r = 0.992). Glucometer Linus readings correspond to the ISO and FDA standards. So, Linus appears to be an accurate device for PG-self-monitoring and clinical practice.

Oral glucose tolerance test performance in olanzapine-treated schizophrenia-spectrum patients is predicted by BMI and triglycerides but not olanzapine dose or duration

“…Blood samples were collected at 15 min before glucose ingestion (−15), immediately before glucose ingestion (0), and thereafter at 15‐, 30‐, 45‐, 60‐, 90‐, and 120‐min time‐points post‐glucose ingestion. Glucose was assessed via glucometer (Chlup, Doubravova, Peterson, Zapletalova, & Bartek, ), while insulin assays were provided by the Biomarkers Core Laboratory at the Yerkes National Primate Research Center using a commercially prepared kit produced by Siemens Healthcare Diagnostics. oGTT was analyzed using the Matsuda index to determine insulin insensitivity, HOMA‐IR to determine insulin resistance, and HOMA‐β to determine beta‐cell function.…”

Glucose sensing module - is it time to integrate it into real-time perioperative monitoring? An observational pilot study with subcutaneous sensors

“…It is essential to calibrate with the most accurate device available, preferably with a laboratory or blood gas analyser. Our pilot study was performed on standard surgery wards without this opportunity, so we used the Wellion Linus glucometer (AgaMatrix, USA) based on technology which prevents the glucose reading to be influenced by the level of haematocrit 51 . None of our patients was calibrated in the state of hypoperfusion.…”

Pathophysiologic Approach to Type 2 Diabetes Management: One Centre Experience 1980–2020

“…[12][13][14] Despite of pumps many persons with T2D were unable to reach the expected metabolic improvement until incretin receptor agonists and gliflozins have been made available. [15,16] In 1974, the first glucometer (Ames) was introduced into clinical practice, followed by tenths of other glucometers [17][18][19], Continuous Glucose Monitors (CGM) [20] and/or Flash Glucose Monitors (FGM) [21]. Today, these devices have become mandatory means (together with HbA1c analysers [22]) to assess the metabolic control.…”