Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior

Abstract

We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis.A total of 68 patients with primary BCCs and 40 patients with PP were included in the study. LDF time series were separated in four scaling levels corresponding to the influences of sympathetic activity (SL1), myogenic activity in the vessel wall (SL2), respiration (SL3) and heart beat (SL4).In BCC, SL1 decreased compared to healthy skin. In all other scaling levels, we found a statistically significant increase of the SLs compared to healthy skin. These increases were not found in PP.Rhythmical behavior of blood flow in malignant tumors is totally different from that in regions with inflammation. In BCCs, thermoregulatory processes, ascribed to sympathetic activity, decrease statistically significant. In contrast, inflammatory processes in PP do not substantially change sympathetic activity. WA of tumor perfusion could open a new noninvasive monitor system for controlling tumor therapy.

Oscillatory pattern of acral skin blood flow within thermoneutral zone in healthy humans

“…Wavelet analysis is the preferred method to analyze infrequent events as the vasoconstrictions of AVA within the thermoneutral zone (Stefanovska et al 1999). Wavelet analysis has mainly been used while investigating non-acral skin (Hafner et al 2007, Hafner et al 2009, with few investigating the acral skin (Jan et al 2013, Dunaev et al 2014. To the best of our knowledge the oscillatory pattern has not been described for acral skin during changing ambient temperatures.…”