Wavelength sequential selection technique for high-throughput multi-channel phase interrogation surface plasmon resonance imaging sensing

Sang, Wei; Huang, Songfeng; Chen, Jiajie; Dai, Xiaoqi; Liu, Haoyu; Zeng, Youjun; Zhang, Teliang; Wang, Xueliang; Qu, Junle; Ho, Ho‐Pui; Shao, Yufeng

doi:10.1016/j.talanta.2023.124405

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Although the PI-SPR technique was successfully applied in protein detection in earlier work, 33 the resolution of the PI-SPR technique remains undiscussed. To better understand the resolution of the PI-SPR aptasensor in detecting miRNAs, we have analyzed the factors influencing the response to the aptamer-miRNA interaction on the PI-SPR aptasensor substrate for the first time.…”

Section: Linear Range and Resolution Of Pi-spr Aptamermentioning

confidence: 99%

“…Therefore, as a typical label-free aptamer, the phase imaging (PI) SPR aptamer transforms the recognition of biomolecules into a phase signal. In our previous studies, 33 through the integration of the wavelength sequential selection (WSS) technique with SPR-phase measurement, the PI-SPR sensor demonstrates a low limit of detection (LOD) of 14.02 ng/mL for proteins with a wide dynamic detection range of 3.7 × 10 −3 RIU. In addition, the PI-SPR aptasensor has profited by simplicity, sensitivity, large throughput, and low sample consumption.…”

Section: Introductionmentioning

confidence: 99%

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Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Liu,

Wang,

Huang

et al. 2024

Anal. Chem.

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MicroRNAs (miRNAs) are novel tumor biomarkers owing to their important physiological functions in cell communication and the progression of multiple diseases. Due to the small molecular weight, short sequence length, and low concentration levels of miRNA, miRNA detection presents substantial challenges, requiring the advancement of more refined and sensitive techniques. There is an urgent demand for the development of a rapid, user-friendly, and sensitive miRNA analysis method. Here, we developed an enhanced biotin–streptavidin dual-mode phase imaging surface plasmon resonance (PI-SPR) aptasensor for sensitive and rapid detection of miRNA. Initially, we evaluated the linear sensing range for miRNA detection across two distinct sensing modalities and investigated the physical factors that influence the sensing signal in the aptamer-miRNA interaction within the PI-SPR aptasensor. Then, an enhanced biotin–streptavidin amplification strategy was introduced in the PI-SPR aptasensor, which effectively reduced the nonspecific adsorption by 20% and improved the limit of detection by 548 times. Furthermore, we have produced three types of tumor marker chips, which utilize the rapid sensing mode (less than 2 min) of PI-SPR aptasensor to achieve simultaneous detection of multiple miRNA markers in the serum from clinical cancer patients. This work not only developed a new approach to detect miRNA in different application scenarios but also provided a new reference for the application of the biotin–streptavidin amplification system in the detection of other small biomolecules.

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Section: Linear Range and Resolution Of Pi-spr Aptamermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Liu,

Wang,

Huang

et al. 2024

Anal. Chem.

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“…For example, Sang et al designed a phase-modulation-based biosensing platform using a sensing wavelength sequential selection technique. 68 The dynamic detection range reaches 3.7 × 10 −3 RIU and the individual image acquisition time is reduced to 1s, enabling high throughput sensing.…”

Section: Working Principlementioning

confidence: 99%

Surface plasmonic biosensors: principles, designs and applications

Liu,

Fu,

Yang

et al. 2023

Analyst

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“…Different designs have been applied to enhance the coupling of the incoming light to the SPR [4,5]. The mechanisms of such devices are purely optical-, phase-, spectral-, angular-, or intensity-interrogated [6][7][8][9][10][11]. A modern simplification of these sensors is obtained by attaching them to photodetectors, which extract the measurable quantity from an electrical signal [12,13].…”

Section: Introductionmentioning

confidence: 99%

Optical Sensing Using Hybrid Multilayer Grating Metasurfaces with Customized Spectral Response

Elshorbagy,

Cuadrado,

Alda

2024

Sensors

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Customized metasurfaces allow for controlling optical responses in photonic and optoelectronic devices over a broad band. For sensing applications, the spectral response of an optical device can be narrowed to a few nanometers, which enhances its capabilities to detect environmental changes that shift the spectral transmission or reflection. These nanophotonic elements are key for the new generation of plasmonic optical sensors with custom responses and custom modes of operation. In our design, the metallic top electrode of a hydrogenated amorphous silicon thin-film solar cell is combined with a metasurface fabricated as a hybrid dielectric multilayer grating. This arrangement generates a plasmonic resonance on top of the active layer of the cell, which enhances the optoelectronic response of the system over a very narrow spectral band. Then, the solar cell becomes a sensor with a response that is highly dependent on the optical properties of the medium on top of it. The maximum sensitivity and figure of merit (FOM) are SB = 36,707 (mA/W)/RIU and ≈167 RIU−1, respectively, for the 560 nm wavelength using TE polarization. The optical response and the high sensing performance of this device make it suitable for detecting very tiny changes in gas media. This is of great importance for monitoring air quality and thecomposition of gases in closed atmospheres.

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Wavelength sequential selection technique for high-throughput multi-channel phase interrogation surface plasmon resonance imaging sensing

Cited by 9 publications

References 22 publications

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Surface plasmonic biosensors: principles, designs and applications

Optical Sensing Using Hybrid Multilayer Grating Metasurfaces with Customized Spectral Response

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