Wavelength optimization for<i> in vivo </i>multispectral photoacoustic/ultrasound tomography of hemoglobin oxygenation in ovarian cancer: clinical studies

Sher, Hassan; Li, Hai; Kumavor, Patrick D.; Меркулов, А. О.; Sanders, Melinda; Brewer, Molly; Zhu, Quing

doi:10.1117/12.2080385

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The problem of selecting the optimal wavelength for two-wavelength OA measurements of blood oxygen saturation has been raised in a number of studies [29][30][31][32][33]. In [29] the use of the condition number of the absorption spectra matrix as an indicator of the stability for linear least squares spectral unmixing was proposed.…”

Section: Introductionmentioning

confidence: 99%

Optimal wavelengths for optoacoustic measurements of blood oxygen saturation in biological tissues

Perekatova¹,

Subochev²,

Kleshnin³

et al. 2016

Biomed. Opt. Express

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The non-invasive measurement of blood oxygen saturation in blood vessels is a promising clinical application of optoacoustic imaging. Nevertheless, precise optoacoustic measurements of blood oxygen saturation are limited because of the complexities of calculating the spatial distribution of the optical fluence. In the paper error in the determination of blood oxygen saturation, associated with the use of approximate methods of optical fluence evaluation within the blood vessel, was investigated for optoacoustic measurements at two wavelengths. The method takes into account both acoustic pressure noise and the error in determined values of the optical scattering and absorption coefficients used for the calculation of the fluence. It is shown that, in conditions of an unknown (or partially known) spatial distribution of fluence at depths of 2 to 8 mm, minimal error in the determination of blood oxygen saturation is achieved at wavelengths of 658 ± 40 nm and 1069 ± 40 nm.

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Section: Introductionmentioning

confidence: 99%

Optimal wavelengths for optoacoustic measurements of blood oxygen saturation in biological tissues

Perekatova¹,

Subochev²,

Kleshnin³

et al. 2016

Biomed. Opt. Express

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“…Multispectral photoacoustic tomography (MPAT) is a rapidly evolving imaging modality, which offers improved resolution of tissue chromophores due to the combination of high resolution of ultrasound imaging with the high molecular specificity resulting from differences in the light absorption by different molecules at different near-infrared wavelengths [1,2]. Due to its ability to facilitate functional, molecular, anatomical and oxygen metabolism expression, MPAT is a widely used tool for many applications among which are the ophthalmology, cardiology, neurology, vascular biology, molecular imaging, multiscale functional imaging, whole-body imaging of small animals, real-time dynamic imaging using tracers [1][2][3][4], and in cancer studies [5,6].…”

Section: Introductionmentioning

confidence: 99%

Wavelength Optimization in the Multispectral Photoacoustic Tomography of the Lymphatic Drainage in Mice

Nassif¹

2021

Preprint

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Multispectral photoacoustic tomography provides a mapping of the tissue chromophore distribution by using a broad range of tunable laser wavelengths. While a large number of employed wavelengths may improve the separation of exogenous and endogenous chromophores, it also decreases the temporal resolution and increases the total energy deposition, which can cause bleaching of fluorescent dyes. With the overall goal of studying the dynamics of cerebrospinal fluid in mice in vivo, the work in this thesis aims to minimize the number of wavelengths in order to reduce the scanning time, improve the temporal resolution, reduce the energy deposition into the tissue and avoid photobleaching of the tracers while maintaining high image quality. Two methods were used to select small sets of wavelengths: the first method of wavelength selection was based on the minimization of the condition number of the extinction matrix, and the second method was based on the peak signal-to-noise ratio optimization of the chromophore images. 3 wavelengths set was selected based on minimum condition number proved to be enough to maintain good image quality and accurate mapping for chromophores and tracer.

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Wavelength optimization in the multispectral photoacoustic tomography of the lymphatic drainage in mice

2018

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Multispectral photoacoustic tomography provides mapping of the tissue chromophore distributions using sets of tunable laser wavelengths. With the overall goal of studying the dynamics of cerebrospinal fluid in mice in vivo, our work aims to minimize the number of wavelengths to reduce scanning time, improve the temporal resolution, reduce the energy deposition and avoid the tracer photobleaching while maintaining high image quality. To select small sets of wavelengths we directly searched for the combinations of wavelengths providing the best and worst image quality in comparison with a reference image obtained using 131 closely spaced wavelengths between 680 and 940 nm in terms of the peak signal-to-noise ratio (PSNR). We have shown that using the PSNR optimization method, additional improvements could be achieved over the wavelength set selected using the method of the minimization of the extinction matrix condition number.

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Wavelength optimization for in vivo multispectral photoacoustic/ultrasound tomography of hemoglobin oxygenation in ovarian cancer: clinical studies

Cited by 4 publications

References 16 publications

Optimal wavelengths for optoacoustic measurements of blood oxygen saturation in biological tissues

Optimal wavelengths for optoacoustic measurements of blood oxygen saturation in biological tissues

Wavelength Optimization in the Multispectral Photoacoustic Tomography of the Lymphatic Drainage in Mice

Wavelength optimization in the multispectral photoacoustic tomography of the lymphatic drainage in mice

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