Wavefront shaping enhanced Raman scattering in a turbid medium

Thompson, Jonathan V.; Throckmorton, Graham A.; Hokr, Brett H.; Yakovlev, Vladislav V.

doi:10.1364/ol.41.001769

Cited by 40 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other ways to overcome inefficient coupling of light into scattering materials have included the use of wavefront shaping (18)(19)(20) to promote coupling into the fundamental diffusion mode (21) or the open/closed eigenchannels (22,23) of the material, thereby controlling energy density (13). An optimum wavefront of the incident light is determined via iterative search algorithms (24,25) or measurement of the transmission/reflection matrix (26) to promote coupling into these modes.…”

mentioning

confidence: 99%

Enhanced coupling of light into a turbid medium through microscopic interface engineering

Thompson

Hokr

Kim

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

There are many optical detection and sensing methods used today that provide powerful ways to diagnose, characterize, and study materials. For example, the measurement of spontaneous Raman scattering allows for remote detection and identification of chemicals. Many other optical techniques provide unique solutions to learn about biological, chemical, and even structural systems. However, when these systems exist in a highly scattering or turbid medium, the optical scattering effects reduce the effectiveness of these methods. In this article, we demonstrate a method to engineer the geometry of the optical interface of a turbid medium, thereby drastically enhancing the coupling efficiency of light into the material. This enhanced optical coupling means that light incident on the material will penetrate deeper into (and through) the medium. It also means that light thus injected into the material will have an enhanced interaction time with particles contained within the material. These results show that, by using the multiple scattering of light in a turbid medium, enhanced light-matter interaction can be achieved; this has a direct impact on spectroscopic methods such as Raman scattering and fluorescence detection in highly scattering regimes. Furthermore, the enhanced penetration depth achieved by this method will directly impact optical techniques that have previously been limited by the inability to deposit sufficient amounts of optical energy below or through highly scattering layers.turbid media | enhanced transmittance | optical coupling | optical scattering | spectroscopy O ptical detection and spectroscopy has drastically changed the way we look at and measure the world today. Observation of the interaction of light with matter provides us with a host of tools to promote research, security, safety, and health. These optical tools include the detection of harmful or explosive materials (1-3), the remote detection of chemicals from a distance (4), the optical diagnosis of colloidal suspensions for genomics and drug delivery (5), and even the use of lasers for defense (6). Remote sensing techniques (7) allow us to image/detect structures through the atmosphere or ocean. Optical methods are also an integral part of biomedical research, diagnosis (8), and treatment (9) of many of today's most prevalent illnesses (10). However, the sensitivity and usefulness of any optical method is severely limited by the occurrence of optical scattering. This limitation is further amplified when the density of scatterers is high enough for multiple scattering to occur. In this article, we show that modification of the geometry of the optical interface significantly improves the coupling efficiency of light into a highly scattering medium, thereby reducing the detrimental effects of scattering. This enhanced coupling is evident through the observation of increased spatial diffusion, two orders of magnitude greater transmission, and over an order of magnitude greater interaction time of light within the material. This translates...

show abstract

mentioning

confidence: 99%

Enhanced coupling of light into a turbid medium through microscopic interface engineering

Thompson

Hokr

Kim

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our proposal can be completely realized in experiments under the current condition in laboratory nowadays, since this setting of phase modulation has been intensively investigated in theory and experiments over recent decades [48,49,[61][62][63][64][65][66][67][68][69][70]. However, different from previous works concentrating mainly on the enhanced intensity of the focused mode [48,49,71,72], our work will focus on the modified quantum fluctuation of the scattered mode.…”

Section: Modified Propagation Via Wavefront Shapingmentioning

confidence: 99%

Modulating quantum fluctuations of scattered light in disordered media via wavefront shaping

Li¹,

Yao²

2019

J. Opt. Soc. Am. B

View full text Add to dashboard Cite

After multiple scattering of quadrature-squeezed lights in a disordered medium, the quadrature amplitudes of the scattered modes present an excess noise above the shot-noise level [Opt. Expr. 14, 6919 (2006)]. A natural question is raised whether there exists a method of suppressing the quadrature fluctuation of the output mode. The answer is affirmative. In this work, we prove that wavefront shaping is a promising method to reduce the quantum noise of quadrature amplitudes of the scattered modes. This reduction is owing to the destructive interference of quantum noise. Specifically, when the single-mode squeezed states are considered as inputs, the quantum fluctuation can always be reduced, even below the shot-noise level. These results may have potential applications in quantum information processing, for instance, sub-wavelength imaging using the scattering superlens with squeezed-state sources.

show abstract

“…To overcome these limitations, researchers have developed various internal guidestars so that diffused photons emerging or propagating through the ROI can be specifically tagged or preferentially detected. 67,79,80 Among the many guidestar options, ultrasound has been demonstrated as a good candidate as it is noninvasive, label-free, and nontoxic. Moreover, ultrasound is scattered much less than light (∼1/1000) in tissues, providing an accurate pinpointing at depths.…”

Section: Guidedstar-assisted Wavefront Shaping-based Optical Focmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

View full text Add to dashboard Cite

Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with specialties in physics and engineering, we anticipate that these technologies can be translated to biological laboratories and clinical settings, which will revolutionize how we diagnose and treat a disease. To provide insight into the physical principle that enables the control of multiple light scattering in biological tissues and how recently developed techniques can improve bioimaging through thick tissues, we summarize recent progress on wavefront shaping techniques for controlling multiple light scattering in biological tissues.

show abstract

Wavefront shaping enhanced Raman scattering in a turbid medium

Cited by 40 publications

References 40 publications

Enhanced coupling of light into a turbid medium through microscopic interface engineering

Enhanced coupling of light into a turbid medium through microscopic interface engineering

Modulating quantum fluctuations of scattered light in disordered media via wavefront shaping

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Contact Info

Product

Resources

About