Waveform Analysis of Ocular Blood Flow and the Early Detection of Normal Tension Glaucoma

Shiga, Yukihiro; Omodaka, Kazuko; Kunikata, Hiroshi; Ryu, Morin; Yokoyama, Yû; Tsuda, S.; Asano, Takao; Maekawa, Shigeto; Maruyama, Kouichi; Nakazawa, Toru

doi:10.1167/iovs.13-12930

Cited by 96 publications

(90 citation statements)

References 58 publications

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“…These new indices have been reported to reflect the augmentation of blood flow resistance basically due to arterial sclerosis as well as aging (i.e., the skew increases and BOT decreases), [27][28][29][30] showing significant correlations with branchial-ankle pulse wave velocity 27 and the stage of glaucoma. 31 The current study demonstrates functional data to further complement the rationale of circulatory abnormalities as the pathogenesis of CSC, showing sequential changes in these pulse waveform parameters on LSFG.…”

mentioning

confidence: 58%

“…S1B, left). 30,31 If the waveform is bilaterally symmetrical, the skew will be zero. When the peak of the waveform is shifted leftward, the skew will become higher.…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…The skew increases as the slope of the waveform after the peak becomes more concave. The skew is calculated as follows 30,31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…Acceleration time index represents the time to reach the peak of MBR 31 and is calculated as follows ( Supplementary Fig. S1B, right) 31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…[17][18][19][20][21][22][23][24][25][26] Our recent study on CSC demonstrates that the macular MBR increases at the acute stage, 19 reinforcing the suspected role of choroidal hyperperfusion in the development of acute CSC. 10 With recent advances of LSFG, various parameters can be automatically calculated to analyze the pulse waveform of MBR averaged in a single heartbeat, 14,[27][28][29][30][31] including the skew, blowout time (BOT), and acceleration time index (ATI), all of which are expressed as absolute values. These new indices have been reported to reflect the augmentation of blood flow resistance basically due to arterial sclerosis as well as aging (i.e., the skew increases and BOT decreases), [27][28][29][30] showing significant correlations with branchial-ankle pulse wave velocity 27 and the stage of glaucoma.…”

mentioning

confidence: 99%

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Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito

Hirooka

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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mentioning

confidence: 58%

“…S1B, left). 30,31 If the waveform is bilaterally symmetrical, the skew will be zero. When the peak of the waveform is shifted leftward, the skew will become higher.…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…The skew increases as the slope of the waveform after the peak becomes more concave. The skew is calculated as follows 30,31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…Acceleration time index represents the time to reach the peak of MBR 31 and is calculated as follows ( Supplementary Fig. S1B, right) 31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

mentioning

confidence: 99%

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Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito

Hirooka

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Evaluation of Parapapillary Choroidal Microvasculature Dropout and Progressive Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma

2019

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choroidal microvasculature dropout (MvD) is considered one of pathophysiological manifestations of glaucomatous damage.OBJECTIVE To evaluate the longitudinal change in the parapapillary choroidal MvD in patients with primary open-angle glaucoma (POAG), and to determine whether this change is associated with progressive retinal nerve fiber layer (RNFL) thinning. DESIGN, SETTING, AND PARTICIPANTSThis prospective observational case series was conducted at a tertiary referral center in Korea and included 68 patients with POAG who exhibited parapapillary choroidal MvD in en face optical coherence tomography (OCT) angiography (OCTA) images who were enrolled from the ongoing Investigating Glaucoma Progression Study from January 1, 2016, through July 31, 2018. The mean (SD) follow-up period was 2.5 (0.2) years and observers were masked to the clinical characteristics of the participants for measurements. The OCTA images were obtained twice at an interval of at least 2 years, during which the RNFL thickness was measured at least 4 times in serial OCT examinations. Microvasculature dropout was defined as a focal sectoral capillary dropout with no visible microvascular network identified in the choroidal layer. The MvD area was measured in the OCTA images obtained at the baseline and the final follow-up. The significance of changes in the MvD area was defined using the 95% Bland-Altman limits of agreement. The rate of RNFL thinning was determined by linear regression of the serial OCT RNFL thickness measurements. MAIN OUTCOMES AND MEASURESThe association between the change in the MvD area and the rate of RNFL thinning. RESULTSOf 68 Korean participants, 37 (54.5%) were women, and the mean (SD) age was 54.3 (13.1) years. Among 68 eyes, 22 (32.4%) showed increases in the MvD area during the follow-up. Faster global RNFL thinning was associated with a larger baseline parapapillary atrophy β-zone (β = −0.55; 95% CI, −0.96 to −0.14; P = .01), disc hemorrhage detection during the follow-up period (β = −0.75; 95% CI, −1.67 to −0.34; P = .001), and a larger increase in the MvD area (β = −4.74; 95% CI, −7.72 to −1.75; P = .002). The MvD area was not associated with the rate of RNFL thinning at baseline or the final follow-up.CONCLUSIONS AND RELEVANCE Microvasculature dropout enlargement was associated with progressive RNFL thinning in POAG.

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Future Novel Imaging Methods

Shahidi

Felder

2020

Essentials in Ophthalmology

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Waveform Analysis of Ocular Blood Flow and the Early Detection of Normal Tension Glaucoma

Abstract: These results suggest that LSFG measurements of waveform changes in ONH BF can differentiate healthy eyes from eyes with NTG, particularly those with mild NTG.

Cited by 96 publications

References 58 publications

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Evaluation of Parapapillary Choroidal Microvasculature Dropout and Progressive Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma

Future Novel Imaging Methods

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