Wave intensity analysis in the internal carotid artery of hypertensive subjects using phase-contrast MR angiography and preliminary assessment of the effect of vessel morphology on wave dynamics

Neumann, Sandra; Sophocleous, Froso; Kobetić, Matthew David; Hart, Emma C J; Nightingale, Angus K; Parker, Kim H.; Hamilton, M.C.K.; Biglino, Giovanni

doi:10.1088/1361-6579/aadfc5

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Furthermore, cPWV calculations were performed based on corrected ROIs, which excluded segments with partial axial vessel coverage (see Supporting Figure S1 for an example of partial vessel coverage in an elderly subject). ROI selection with the aforementioned constraint is important especially in older subjects, which are known to have more tortuous cerebral arteries 20 (representative CCA-ICA segment geometries in a young and an elderly subject are shown in Supporting Figure S1). We found that, as long as both CCA and ICA segments are included in the ROI, excluding a relatively large region around the carotid bifurcation did not significantly change the calculated cPWV values ( Figure 6), suggesting that using multiple waveforms throughout the CCA-ICA segment makes the implemented cPWV calculation technique robust to ROI alterations.…”

Section: F I G U R Ementioning

confidence: 99%

“…Although TCD is widely available and its recent developments has made it less prone to artefacts of earlier implementations, 15 TCD measurements are operator‐dependent and their application is contingent upon the availability of an acoustic window, which is known to be limited in older subjects 16 . Moreover, TCD‐based PWV quantifications rely on body surface distance to estimate vessel length, which could have limited accuracy, 17‐19 especially in older subjects which are known to have more tortuous internal carotid arteries (ICA) compared to younger adults 20 …”

Section: Introductionmentioning

confidence: 99%

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Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single‐slice oblique‐sagittal phase‐contrast MRI

Pahlavian

Cen

et al. 2021

Magnetic Resonance in Med

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Increased arterial stiffness has been shown to be one of the earliest markers of cerebrovascular dysfunction. As a surrogate marker of arterial stiffness, pulse wave velocity (PWV) quantifications are generally carried out on central and peripheral arteries. The purpose of this study was to develop and evaluate an MRI approach to assess carotid stiffness by measuring carotid PWV (cPWV) using a fast obliquesagittal phase-contrast MRI sequence. Methods: In 29 volunteers, a single-slice oblique-sagittal phase-contrast MRI sequence with retrospective cardiac gating was used to quantify blood velocity waveforms along a vessel segment covering the common carotid artery (CCA) and the internal carotid artery (ICA). The CCA-ICA segment length was measured from a region of interest selected on the magnitude image. Phase-contrast MRI-measured velocities were also used to quantify the ICA pulsatility index along with cPWV quantification. Results: The mean value of cPWV calculated using the middle upslope area algorithm was 2.86 ± 0.71 and 3.97 ± 1.14 m/s in young and elderly subjects, respectively. Oblique-sagittal phase-contrast MRI-derived cPWV measurements showed excellent intrascan and interscan repeatability. cPWV and ICA pulsatility index were significantly greater in older subjects compared to those in the young subjects (P < .01 and P = .01, respectively). Also, increased cPWV values were associated with elevated systolic blood pressure (β = 0.05, P = .03). Conclusion: This study demonstrated that oblique-sagittal phase-contrast MRI is a feasible technique for the quantification of both cPWV and ICA pulsatility index and showed their potential utility in evaluating cerebroarterial aging and age-related neurovascular disorders.

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Section: F I G U R Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single‐slice oblique‐sagittal phase‐contrast MRI

Pahlavian

Cen

et al. 2021

Magnetic Resonance in Med

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“…Recently, the CRADL project has introduced the continuous assessment of regional lung function using Electrical Impedance Tomography (EIT) technology as supportive care for the most common causes of paediatric respiratory failure ( http://cradlproject.org/ ). As part of the project, a textile electrode patient interface for the neonatal EIT measurement (SenTec AG, CH) has been developed and tested to validate its clinical performance in a multicentre clinical study 2 . Results showed the absence of any discomfort for the patients whilst providing a low contact impedance, which ensures that good quality measurements can be taken.…”

Section: Introductionmentioning

confidence: 99%

Thoracic shape changes in newborns due to their position

Gelidi

Bardill

Seifnaraghi

et al. 2021

Sci Rep

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The highly compliant nature of the neonatal chest wall is known to clinicians. However, its morphological changes have never been characterized and are especially important for a customised monitoring of respiratory diseases. Here, we show that a device applied on newborns can trace their chest boundary without the use of radiation. Such technology, which is easy to sanitise between patients, works like a smart measurement tape drawing also a digital cross section of the chest. We also show that in neonates the supine position generates a significantly different cross section compared to the lateral ones. Lastly, an unprecedented comparison between a premature neonate and a child is reported.

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“…Aortic distensibility, as well as ventriculo-arterial coupling, can be assessed by an established mathematical technique called wave intensity analysis (WIA) ( 11 ). This is traditionally derived from pressure and velocity data, but it can also be formulated using velocity and area, thus rendering the analysis applicable to phase contrast cardiac magnetic resonance (PC-CMR) ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights?

et al. 2021

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Background: Conotruncal anomalies (CTA) are associated with ongoing dilation of the aortic root, as well as increased aortic stiffness, which may relate to intrinsic properties of the aorta. Pregnancy hormones lead to hemodynamic changes and remodeling of the tunica media, resulting in the opposite effect, i.e., increasing distensibility. These changes normalize post-pregnancy in healthy women but have not been fully investigated in CTA patients.Methods: We examined aortic distensibility and ventriculo-arterial coupling before and after pregnancy using cardiovascular magnetic resonance (CMR)-derived wave intensity analysis (WIA). Pre- and post-pregnancy CMR data were retrospectively analyzed. Aortic diameters were measured before, during, and after pregnancy by cardiac ultrasound and before and after pregnancy by CMR. Phase contrast MR flow sequences were used for calculating wave speed (c) and intensity (WI). A matched analysis was performed comparing results before and after pregnancy.Results: Thirteen women (n = 5, transposition of the great arteries; n = 6, tetralogy of Fallot; n = 1, double outlet right ventricle, n = 1, truncus arteriosus) had 19 pregnancies. Median time between delivery and second CMR was 2.3 years (range: 1–6 years). The aortic diameter increased significantly after pregnancy in nine (n = 9) patients by a median of 4 ± 2.3 mm (range: 2–7.0 mm, p = 0.01). There was no difference in c pre-/post-pregnancy (p = 0.73), suggesting that increased compliance, typically observed during pregnancy, does not persist long term. A significant inverse relationship was observed between c and heart rate (HR) after pregnancy (p = 0.01, r = 0.73). There was no significant difference in cardiac output, aortic/pulmonary regurgitation, or WI peaks pre-/post-pregnancy.Conclusions: WIA is feasible in this population and could provide physiological insights in larger cohorts. Aortic distensibility and wave intensity did not change before and after pregnancy in CTA patients, despite an increase in diameter, suggesting that pregnancy did not adversely affect coupling in the long-term.

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Wave intensity analysis in the internal carotid artery of hypertensive subjects using phase-contrast MR angiography and preliminary assessment of the effect of vessel morphology on wave dynamics

Cited by 11 publications

References 19 publications

Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single‐slice oblique‐sagittal phase‐contrast MRI

Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single‐slice oblique‐sagittal phase‐contrast MRI

Thoracic shape changes in newborns due to their position

Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights?

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