Abstract:Cadherin dynamics drive morphogenesis, while defects in Cadherin polarity contribute to diseases, including cancers. However, the forces polarizing Cadherin membrane distribution are not well understood. We previously showed that WAVE-dependent branched actin polarizes Cadherin distribution, and suggested one mechanism is protein transport. While previous studies suggested that WAVE is enriched at various endocytic organelles, the role of WAVE in protein traffic is understudied. Here we test the model that WAV… Show more
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