Watermelon-stomach as a cause of chronic iron deficiency anemia in a patient with systemic sclerosis

Fábián, György; E, Tóvári; Baranyay, Ferenc; Czirják, László

doi:10.1016/s0926-9959(98)00140-8

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Although there are reported cases when GAVE is the only manifestation of systemic sclerosis [ 29 ], studies have shown that the majority of patients with GAVE, around 60%, have telangiectasias of the skin [ 30 ]. Most of the patients present either with symptomatic iron deficiency anemia (weakness, fatigue, or dyspnea) or asymptomatic anemia (with laboratory findings like low hemoglobin and mean corpuscular volume) [ 19 , 31 ]. The primary physician must suspect GAVE when the anemia is refractory to regular treatment [ 32 ].…”

Section: Clinical Findings and Diagnosismentioning

confidence: 99%

Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts

Parrado

Lemus

Coral-Alvarado

et al. 2015

International Journal of Rheumatology

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Introduction. Gastric antral vascular ectasia (GAVE) is a rare entity with unique endoscopic appearance described as “watermelon stomach.” It has been associated with systemic sclerosis but the pathophysiological changes leading to GAVE have not been explained and still remain uncertain. Methods. Databases Medline, Scopus, Embase, PubMed, and Cochrane were searched for relevant papers. The main search words were “Gastric antral vascular ectasia,” “Watermelon Stomach,” “GAVE,” “Scleroderma,” and “Systemic Sclerosis.” Fifty-four papers were considered for this review. Results. GAVE is a rare entity in the spectrum of manifestations of systemic sclerosis with unknown pathogenesis. Most patients with systemic sclerosis and GAVE present with asymptomatic anemia, iron deficiency anemia, or heavy acute gastrointestinal bleeding. Symptomatic therapy and endoscopic ablation are the first-line of treatment. Surgical approach may be recommended for patients who do not respond to medical or endoscopic therapies. Conclusion. GAVE can be properly diagnosed and treated. Early diagnosis is key in the management of GAVE because it makes symptomatic therapies and endoscopic approaches feasible. A high index of suspicion is critical. Future studies and a critical review of the current findings about GAVE are needed to understand the role of this condition in systemic sclerosis.

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Section: Clinical Findings and Diagnosismentioning

confidence: 99%

Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts

Parrado

Lemus

Coral-Alvarado

et al. 2015

International Journal of Rheumatology

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“…Dieser endoskopische Befund erinnert an die Oberflächenzeichnung einer Wassermelone, deshalb wurde der Begriff "Wassermelonen-Magen" 1984 von Jabbari et al [3] eingeführt. Betroffene Patienten sind zumeist Frauen im Alter über 60 Jahre [3][4][5][6][7][8][9]. Die Diagnose wird aufgrund der gezielten Biopsie aus der Kuppe der geröteten hypertrophen Magenfalten im Antrum gesichert: Histologisch wurden schon vor der Einführung des Begriffs "Wassermelonen-Magen" im Biopsiematerial Teleangiektasien, oft mit fokalen Mikrothromben in den dilatierten Kapillaren beschrieben [10,11].…”

Section: Originalarbeit 221unclassified

„Wassermelonen-Magen“: Endoskopisch relativ häufig als „hämorrhagische Gastritis“ fehldiagnostiziert

Stolte¹,

Rubenbauer²

2010

Endo heute

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Ein praktischer Ansatz zur Therapie der systemischen Sklerose

Czirják

2004

Z Rheumatol

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Systemic sclerosis (SSc) is characterised by vascular abnormalities, fibrosis, inflammatory changes, and atrophy affecting the skin and several internal organs. The course of the disease is highly variable from patient to patient, and the different organ manifestations may show a different stage of activity and damage. More extensive skin involvement coincides with more severe internal organ manifestation(s) resulting in an unfavourable outcome of disease. Subset classification and organ system involvements should be carefully determined before introducing the therapy. Prognostic evaluation, including the staging of disease severity, damage, activity and the definition of longitudinal disease behaviour of the organ manifestations (by serial investigations) is also crucial. Theoretically the treatment should focus on both the early reduction of inflammatory phenomena and influence of vascular symptoms to prevent the development of tissue fibrosis and atrophy. Major internal organ manifestations including gastro-oesophageal reflux, scleroderma renal involvement, different cardio-respiratory disorders should also be carefully looked for, and early signs of internal organ involvements should be recognized and treated. There is no disease modifying drug therapy of proven efficacy in SSc but an individualized, well designed therapy may be remarkably efficient in terms of improving the prognosis and quality of life of patients. Education of patients is also compelling.

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Watermelon-stomach as a cause of chronic iron deficiency anemia in a patient with systemic sclerosis

Cited by 5 publications

References 7 publications

Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts

Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts

„Wassermelonen-Magen“: Endoskopisch relativ häufig als „hämorrhagische Gastritis“ fehldiagnostiziert

Ein praktischer Ansatz zur Therapie der systemischen Sklerose

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