Water, urea, sodium, chloride, and potassium transport in the in vitro isolated perfused papillary collecting duct

Rocha, Antonino S.; Kudo, Lúcia H.

doi:10.1038/ki.1982.201

Cited by 94 publications

(47 citation statements)

References 29 publications

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“…Previous studies have shown that vasopressin stimulates both osmotic water permeability and urea permeability in the rat terminal IMCD (17)(18)(19). The studies presented here, in isolated perfused tubules from the terminal part of the IMCD, show that physiological concentrations of ANF significantly inhibit vasopressin-stimulated osmotic water permeability without affecting urea permeability.…”

mentioning

confidence: 48%

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

Nonoguchi¹,

Sands²,

Knepper³

1988

J. Clin. Invest.

110

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mentioning

confidence: 48%

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

Nonoguchi¹,

Sands²,

Knepper³

1988

J. Clin. Invest.

110

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“…One important characteristic of the loop of Henle is that the thin and thick ascending limbs are impermeable to water [3]. Since active salt reabsorption continues in this segment, there is dilution of tubular fluid such that luminal sodium chloride concentration [NaCl] and osmolality approach values that are approximately one third of the values found in plasma [4]. Shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

ATP as a mediator of macula densa cell signalling

Bell

Komlósi

Zhang

2009

Purinergic Signalling

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Within each nephro-vascular unit, the tubule returns to the vicinity of its own glomerulus. At this site, there are specialised tubular cells, the macula densa cells, which sense changes in tubular fluid composition and transmit information to the glomerular arterioles resulting in alterations in glomerular filtration rate and blood flow. Work over the last few years has characterised the mechanisms that lead to the detection of changes in luminal sodium chloride and osmolality by the macula densa cells. These cells are true "sensor cells" since intracellular ion concentrations and membrane potential reflect the level of luminal sodium chloride concentration. An unresolved question has been the nature of the signalling molecule(s) released by the macula densa cells. Currently, there is evidence that macula densa cells produce nitric oxide via neuronal nitric oxide synthase (nNOS) and prostaglandin E 2 (PGE 2 ) through cyclooxygenase 2 (COX 2)-microsomal prostaglandin E synthase (mPGES). However, both of these signalling molecules play a role in modulating or regulating the macula-tubuloglomerular feedback system. Direct macula densa signalling appears to involve the release of ATP across the basolateral membrane through a maxi-anion channel in response to an increase in luminal sodium chloride concentration. ATP that is released by macula densa cells may directly activate P2 receptors on adjacent mesangial cells and afferent arteriolar smooth muscle cells, or the ATP may be converted to adenosine. However, the critical step in signalling would appear to be the regulated release of ATP across the basolateral membrane of macula densa cells.

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“…First, under normal nondiuretic conditions in rats, the luminal urea concentration in the inner medullary collecting ducts exceeds that in neighboring vasa recta, providing a concentration gradient favorable for passive absorption (5,7). Second, permeability measurements in rat inner medullary collecting ducts have demonstrated a very high passive urea permeability, which is increased further by vasopressin (14,15).…”

Section: Introductionmentioning

confidence: 99%

“…The urea permeability of isolated inner medullary collecting ducts from rabbits (16) was found to be an order of magnitude lower than values measured in inner medullary collecting ducts from rats (14,15). Rector (17) has questioned whether this permeability is sufficient to allow adequate rates of urea absorption from rabbit inner medullary collecting ducts to replace urea lost via the vasa recta and loop of Henle.…”

Section: Introductionmentioning

confidence: 99%

Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium.

Sands¹,

Knepper²

1987

J. Clin. Invest.

154

123

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To compare passive urea transport across the inner medullary collecting ducts (IMCDs) and the papillary surface epithelium (PSE) of the kidney, two determinants of passive transport were measured, namely permeability coefficient and surface area. Urea permeability was measured in isolated perfused IMCDs dissected from carefully localized sites along the inner medullas of rats and rabbits. Mean permeability coefficients (X10-5 cm/s) in rat

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Water, urea, sodium, chloride, and potassium transport in the in vitro isolated perfused papillary collecting duct

Cited by 94 publications

References 29 publications

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

ATP as a mediator of macula densa cell signalling

Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium.

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