Water state and diffusion through lipid bilayers: Effect of hydration degree

Khakimov, A. M.; Rudakova, Maya; Филиппов, А. В.

doi:10.1134/s0006350907050016

Cited by 1 publication

(2 citation statements)

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“…The structural details in Table reveal that the nanoparticles strongly dehydrated the heads and tails of the supported and floating lipid bilayer. Since water plays a structure-forming role in lipid bilayers and is essential for the molecular mobility, the hydration degree influences the morphology of the system and can also change the temperature of the gel–liquid phase transition. , With increasing dehydration, the bilayer thickness should normally increase, while the area per lipid molecule decreases. This affects the bilayer fluidity as well as its lateral and transverse diffusion properties. , The decrease in the hydration level of the lipid bilayers upon interaction with anionic COOHAu NPs was, however, associated with a decrease in the floating bilayer thickness, indicating its susceptibility to disintegrate and to form lipid vesicles .…”

Section: Discussionmentioning

confidence: 99%

“…Since water plays a structure-forming role in lipid bilayers and is essential for the molecular mobility, the hydration degree influences the morphology of the system and can also change the temperature of the gel−liquid phase transition. 44,43 With increasing dehydration, the bilayer thickness should normally increase, while the area per lipid molecule decreases. This affects the bilayer fluidity as well as its lateral and transverse diffusion properties.…”

Section: ■ Discussionmentioning

confidence: 99%

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Effect of Functionalized Gold Nanoparticles on Floating Lipid Bilayers

et al. 2013

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The development of novel nano-engineered materials poses important questions regarding the impact of these new materials on living systems. Possible adverse effects must be assessed in order to prevent risks for health and the environment. On the other hand, a thorough understanding of their interaction with biological systems might also result in the creation of novel biomedical applications. We present a study on the interaction of model lipid membranes with gold nanoparticles (AuNP) of different surface modifications. Neutron reflectometry experiments on zwitterionic lipid double bilayers were performed in the presence of AuNP functionalized with cationic and anionic head groups. Structural information was obtained that provided insight into the fate of the AuNPs with regard to the integrity of the model cell membranes. The AuNPs functionalized with cationic head groups penetrate into the hydrophobic moiety of the lipid bilayers and cause membrane disruption at an increased concentration. In contrast, the AuNPs functionalized with anionic head groups do not enter but seem to impede the destruction of the lipid bilayer at an alkaline pH. The information obtained might influence the strategy for a better nanoparticle risk assessment based on a surface charge evaluation and contribute to nano-safety considerations during their design.

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