Water-stable perovskite-loaded nanogels containing antioxidant property for highly sensitive and selective detection of roxithromycin in animal-derived food products

Abstract

Luminescent inorganic lead halide perovskite nanoparticles lack stability in aqueous solutions, limiting their application to optical sensors. Here, hybrid CsPbBr3-loaded MIP nanogels were developed with enhanced stability in aqueous media. Multifunctional MIP nanogels with antioxidant function and hydrophobic cavities were synthesized from HEMA derivatives in the presence of roxithromycin as a template. The CsPbBr3 nanoparticles were loaded into pre-synthesized MIP nanogels via in-situ synthesis with a size distribution of 200 nm. The developed CsPbBr3-nanogel exhibits excellent stability to air/moisture and enhanced stability toward an aqueous solvent. The developed CsPbBr3-loaded MIP nanogels showed a selective and sensitive detection of ROX with a limit of detection calculated to be 1.7 × 10–5 μg/mL (20.6 pM). The developed CsPbBr3-loaded MIP antioxidant-nanogels were evaluated on practical application for the quantitative determination of ROX antibiotic in animal-derived food products with excellent analytical performance. The detection of ROX in animal-derived food products showed good recovery results, making them an ideal candidate for sensing ROX.

An electrochemiluminescent sensor based on hydrophilic CsPbBr3/TDPA nanocrystals for sensitive detection of nitrobenzene

“…4, after one day of CsPbBr 3 /TDPA NCs dispersion in water, the ECL intensity still remained at 90% of the initial intensity. Compared to a previous study, 34 it is worth noting that after a week of dispersion in water, the ECL intensity of the NCs was still 40% of the initial intensity, indicating that the water stability of the NCs was excellent. We conclude that the combined action of TDPA and OAm can improve the water stability of ECL and play an important role in delaying the degradation rate of CsPbBr 3 NCs in water.…”

Recent advances in synthesis of water-stable metal halide perovskites and photocatalytic applications

“…118 In addition, polymer matrices are capable of water uptake via water-induced swelling process 119 and thus alleviate the direct contact of water and MHPs to a degree. 120…”

Perovskite Nanocrystals: Superior Luminogens for Food Quality Detection Analysis

“…The presence of roxithromycin in samples could quench the fluorescence of water-stable CsPbBr 3 perovskite through the specific combination of roxithromycin and MIPs cavities. The developed fluorescent biosensor achieved a LOD as lower as 1.7 × 10 –5 μg mL –1 (20.6 pM) in the linear range of 1 × 10 –6 –1 × 10 –10 M and good recoveries ranging from 3.66% to 6.99% in pork meat …”