Water-stable and finasteride-loaded polyvinyl alcohol nanofibrous particles with sustained drug release for improved prostatic artery embolization — In vitro and in vivo evaluation

Li, Xiaohong; Li, Basen; Panday, Raju; Cao, Jiameng; Li, Qiubai; Zhang, Yaopeng; Wang, Liang; Yang, Guang

doi:10.1016/j.msec.2020.111107

Cited by 10 publications

(7 citation statements)

References 54 publications

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Section: Hemorrhagementioning

confidence: 99%

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Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

Ullah

et al. 2023

Adv Healthcare Materials

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Transcatheter arterial embolization, a minimally invasive treatment to deliberately occlude the blood vessels, has become a safe and effective procedure for the management of vascular diseases and benign/malignant tumors. Particularly, hydrogel‐based embolic agents have garnered much attention because of their potential to address some of the limitations of clinically used embolic agents and can be rationally designed to impart more favorable characteristics or functions. In this review, the recent progress toward the development of polymer‐based hydrogels for effective endovascular embolization, including the in situ gelling hydrogels mediated by physically or chemically crosslinking, imageable hydrogels for intraprocedural and postprocedural feedback, use of hydrogels as the drug depot for local delivery of therapeutic drugs, hemostatic hydrogels inducing extrinsic or intrinsic coagulation of blood, stimuli‐responsive shape memory hydrogels as the smart embolization devices, and hydrogels incorporating external‐stimuli functional materials for multidisciplinary therapy, is systemically summarized. Moreover, the potential considerations of hydrogel‐based embolic agents confronted in therapeutic embolization are pointed out. Finally, the perspectives for the development of more effective embolic hydrogels are also highlighted.

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Section: Hemorrhagementioning

confidence: 99%

mentioning

confidence: 99%

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

Ullah

et al. 2023

Adv Healthcare Materials

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“…The spectrum of PVA shows characteristic peaks such as 3278 cm -1 (O-H stretching), 2935 cm -1 (C-H stretching), 1470 cm -1 (CH 2 deformation), and -CO stretching at around 1711 and 1115 cm -1 (C-O-C stretching). [18,32] The FTIR spectra of BC-PVA3% and BC-PVA6% scaffolds contain the bands characterizing both the individual polymers. The shape of the hydroxyl band in the FTIR spectrum of BC-PVA is similar to that of pristine BC; however, it became broader with the increasing PVA content, indicating the formation of intermolecular hydrogen bonding between the OH of PVA and BC.…”

Section: Chemical Thermal and Mechanical Properties Of Scaffoldsmentioning

confidence: 99%

“…[17] Poly(vinyl alcohol) (PVA), a synthetic polymer, has been used as the reinforcement material in the development of biomedical composites. [18] It has received immense consideration owing to its hydrophilic nature, good mechanical properties, and high biocompatibility. [19] Herein, the modified PVA was added to the culture medium (in situ method), which was impregnated between the growing cellulose fibers and formed a BC-PVA composite.…”

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confidence: 99%

In Situ Synthesized Porous Bacterial Cellulose/Poly(vinyl alcohol)‐Based Silk Sericin and Azithromycin Release System for Treating Chronic Wound Biofilm

Bakadia

Boni

Ahmed

et al. 2022

Macromolecular Bioscience

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Chronic wounds are associated with infectious microbial complex communities called biofilms. The management of chronic wound infection is limited by the complexity of selecting an appropriate antimicrobial dressing with antibiofilm activity due to antimicrobial resistance in biofilms. Herein, the in situ developed bacterial cellulose/poly(vinyl alcohol) (BC–PVA) composite is ex situ modified with genipin‐crosslinked silk sericin (SS) and azithromycin (AZM) (SSga). The composite is evaluated as a wound dressing material for preventing the development, dispersion, and/or eradication of microbial biofilm. Fourier transform infrared spectroscopy confirms the intermolecular interactions between the components of BC–PVA@SSga scaffolds. The addition of PVA during BC production significantly increases the porosity from 53.5% ± 2.3% to 83.5% ± 2.9%, the pore size from 2.3 ± 1.9 to 16.8 ± 4.5 µm, the fiber diameter from 35.5 ± 10 to 120 ± 27.4 nm, and improves the thermal stability and flexibility. Studies using bacteria and fungi indicate high inhibition and disruption of biofilms upon AZM addition. In vitro biocompatibility analysis confirms the nontoxic nature of BC–PVA@SSga toward HaCaT and NIH3T3 cells, whereas the addition of SS enhances cell proliferation. The developed BC–PVA@SSga accelerates wound healing in the infected mouse model, thus can be a promising wound dressing biomaterial.

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“…In vivo studies performed on rabbit ears did demonstrate evidence of ischemia due to the embolic effect. Another study evaluated embolization particles (PVA nanofibrous particles) loaded with finasteride compared to bland particles in a canine model [ 77 ]. Follow up imaging was performed at 1, 3- and 6-month intervals.…”

Section: Future Directionsmentioning

confidence: 99%

Prostate Artery Embolization—Review of Indications, Patient Selection, Techniques and Results

Naidu

Narayanan

Saini

et al. 2021

JCM

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Lower urinary tract symptoms (LUTS) due to benign prostatic hypertrophy (BPH) are a very common problem in men ranging from mild urinary symptoms to recurrent urinary tract infections or renal failure. Numerous treatment options are available ranging from conservative medical therapies to more invasive surgical options. Prostate artery embolization (PAE) has emerged as a novel treatment option for this common problem with clinical efficacy comparable to the current surgical gold standard, transurethral resection of the prostate (TURP). PAE offers fewer complications and side effects without a need for general anesthesia or hospitalization. This review discusses the indications for prostate artery embolization in addition to LUTS, patient evaluation in patients with LUTS, PAE technique and clinical results, with an emphasis on efficacy and safety.

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Water-stable and finasteride-loaded polyvinyl alcohol nanofibrous particles with sustained drug release for improved prostatic artery embolization — In vitro and in vivo evaluation

Cited by 10 publications

References 54 publications

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

In Situ Synthesized Porous Bacterial Cellulose/Poly(vinyl alcohol)‐Based Silk Sericin and Azithromycin Release System for Treating Chronic Wound Biofilm

Prostate Artery Embolization—Review of Indications, Patient Selection, Techniques and Results

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