Water Sorption and Solubility of Methacrylate Resin–based Root Canal Sealers

Donnelly, Adam; Sword, Jeremy; Nishitani, Yosuke; Yoshiyama, Masahiro; Agee, Kelli A.; Tay, Franklin R.; Pashley, David H.

doi:10.1016/j.joen.2006.03.021

Cited by 95 publications

(100 citation statements)

References 28 publications

(38 reference statements)

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“…112 The reported cytotoxicity may be due to the leakage of uncured monomer from the oxygen inhibition layer, 100,101,113,114 or due to the degradation of the sealer in an aqueous environment. [115][116][117] The Bis-GMA and UDMA contained within the Epiphany bonding agent are another potential source of cytotoxicity. 99,101,105,118 However, several in vivo studies have shown the biocompatibility of Epiphany to be acceptable.…”

Section: Biocompatibilitymentioning

confidence: 99%

Root canal filling using Resilon: a review

Shanahan

Duncan

2011

Br Dent J

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Section: Biocompatibilitymentioning

confidence: 99%

Root canal filling using Resilon: a review

Shanahan

Duncan

2011

Br Dent J

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“…Although endodontic sealers are ideally contained within the canal space, 1 they may be extruded through the apical constriction during placement into direct contact with hard and soft periradicular tissues. 2 With or without extrusion, elutes from endodontic sealers 3,4 may expose periradicular tissues 5 and have the potential to delay wound healing. 6 Thus, the biocompatibility of endodontic sealers is important to the success of root canal treatment.…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of monocytic cytokine secretion by endodontic sealers

et al. 2011

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Recent studies have reported that sealers may alter the secretion of specific cytokines from THP1 monocytic cells in vitro. In this study, a cytokine array was used to determine if endodontic sealers changed secretion of 42 cytokines. White mineral trioxide aggregate (WMTA), MTA preparation (CS), AH-Plus (AHP), and Pulp Canal Sealer (PCS) were mixed, allowed to set for 72 h, then "aged" in buffered-saline for 12 weeks. Aged specimens were placed in direct contact with THP1 for 72 h and their cytotoxicity (MTT assay) was assessed. Materials that were not severely toxic were then exposed to THP1 with or without lipolysaccharide (LPS), and the culture medium was assayed for cytokine secretion. Secretion of cytokines was quantified using infrared scanning (Odyssey(®)); replicate pairs were averaged. PCS severely suppressed MTT activity and was not assessed for its influence on cytokine secretion. WMTA, CS, and AHP induced a broad-based increase in cytokine secretion (>20% vs. Teflon controls), but AHP induced the greatest increase (>100% in 17 of 42 cytokines). The effects of the sealers on LPS-activated THP1 were biphasic, with some increases and decreases cytokine secretion of >20%, but few larger effects. This work shows endodontic sealers may alter the secretion of a broad cross section of cytokines from monocytic cells.

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“…25,26 Comparatively better sealing ability was obtained for Resilon/Epiphany SE. The reduced leakage in this group may be explained by the water sorption property of methacrylate resinbased root canal sealers, such as Epiphany SE, 27 which leads to expansion. 28 The third null hypothesis of this study was not rejected.…”

mentioning

confidence: 95%

“…4,31,32 Once water sorption occurs, composite materials are susceptible to solubility. 27 Dissolution of the AH Plus and Epiphany SE sealers occurs over long time periods and may permit gap formation between the dentinal walls and root filling materials. 27,33 The resulting fluid movement through nanometer-sized voids along the collagen fibrils within the hybrid layer is detrimental to the bond integrity over time.…”

mentioning

confidence: 99%

Influence of pH Change and Water Storage on the Sealing Ability of Two Resin-based Root-filling Materials

Souza

Pereira

et al. 2015

The Journal of Contemporary Dental Practice

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Aim:To evaluate the influence of pH change and water storage up to 90 days on the sealing ability of two resin-based rootfilling materials. Materials and methods:Forty-four human mandibular singlerooted teeth were instrumented and filled with gutta-percha/ AH Plus or Resilon/Epiphany SE (n = 20 per group). Two teeth each were used as positive and negative controls. Specimens were set for 7 days under 100% humidity at 37ºC. They were allocated into two subgroups (n = 10) according to whether they were tested immediately or stored for up to 90 days in water before testing. Sealing ability was evaluated by passive dye penetration. Absorbance at 630 nm (in µg/ml) was measured by spectrophotometry. The pH values were obtained in triplicate. Data were submitted to ANOVA by post-hoc Tukey's test (α = 0.05).Results: Specimens filled with Resilon/Epiphany SE exhibited more leakage than specimens filled with gutta-percha/AH Plus at the immediate time point (p < 0.001). No differences were detected between the groups after storage, or between the materials with pH changes after 30, 60 and 90 days (p > 0.05). Conclusion:Gutta-percha/AH Plus provided superior sealing at the immediate time point. Water storage and pH changes did not influence the sealing ability of tested materials.Clinical significance: These results suggest that Resilon/ Epiphany SE sealer offered no apparent advantage over the more conventional gutta-percha/AH Plus sealer technique in terms of sealing ability.

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Water Sorption and Solubility of Methacrylate Resin–based Root Canal Sealers

Cited by 95 publications

References 28 publications

Root canal filling using Resilon: a review

Root canal filling using Resilon: a review

Dysregulation of monocytic cytokine secretion by endodontic sealers

Influence of pH Change and Water Storage on the Sealing Ability of Two Resin-based Root-filling Materials

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