Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

Miyake, Kazumasa; Akimoto, Teppei; Kusakabe, Makoto; Sato, Wataru; Yamada, Akihiro; Yanagawa, Hiroshi; Kodaka, Yasuhiro; Shinpuku, Mayumi; Nagoya, Hiroyuki; Sò, Tomotaka; Ueki, Nobue; Kusunoki, Masafumi; Kawagoe, Tetsuro; Futagami, Seiji; Tsukui, Taku; Sakamoto, Choitsu

doi:10.3177/jnsv.59.503

Cited by 3 publications

(4 citation statements)

References 34 publications

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“…Additionally, Aditi and Graham [ 25 ] documented that Vitamin C (ascorbic acid) plays a very important role in the conservation and treatment of the gastric mucosa and that deficiency in vitamin C has repeatedly been linked with PUD. Our findings in women are consistent with the results of previous studies [ 22 , 24 , 25 ]. In this study, fiber, vitamin B2 (riboflavin), sodium, and ash were significantly associated with PUD in women in both the crude and adjusted analyses.…”

Section: Discussionsupporting

confidence: 94%

“…They argued that vitamin B2 and potassium were inversely associated with the risk of duodenal ulcer. Miyake and colleagues [ 24 ] reported that a lack of water-soluble vitamins could accelerate the development of PUD in Japanese adults. Additionally, Aditi and Graham [ 25 ] documented that Vitamin C (ascorbic acid) plays a very important role in the conservation and treatment of the gastric mucosa and that deficiency in vitamin C has repeatedly been linked with PUD.…”

Section: Discussionmentioning

confidence: 99%

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Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Kim

Lee

2017

PLoS ONE

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ObjectivesPeptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been reported. The aim of this study was to assess associations of anthropometrics, blood parameters, nutritional components, and lifestyle factors with PUD in the Korean population.MethodsData were collected from a nationally representative sample of the South Korean population using the Korea National Health and Nutrition Examination Survey. Logistic regression was used to examine associations of anthropometrics, blood parameters and nutritional components among patients with PUD.ResultsAge was the factor most strongly associated with PUD in women (p = <0.0001, odds ratio (OR) = 0.770 [0.683–0.869]) and men (p = <0.0001, OR = 0.715 [0.616–0.831]). In both crude and adjusted analyses, PUD was highly associated with weight (adjusted p = 0.0008, adjusted OR = 1.251 [95%CI: 1.098–1.426]), hip circumference (adjusted p = 0.005, adjusted OR = 1.198 [1.056–1.360]), and body mass index (adjusted p = 0.0001, adjusted OR = 1.303 [1.139–1.490]) in women and hip circumference (adjusted p = 0.0199, adjusted OR = 1.217 [1.031–1.435]) in men. PUD was significantly associated with intake of fiber (adjusted p = 0.0386, adjusted OR = 1.157 [1.008–1.328], vitamin B2 (adjusted p = 0.0477, adjusted OR = 1.155 [1.001–1.333]), sodium (adjusted p = 0.0154, adjusted OR = 1.191 [1.034–1.372]), calcium (adjusted p = 0.0079, adjusted OR = 1.243 [1.059–1.459]), and ash (adjusted p = 0.0468, adjusted OR = 1.152 [1.002–1.325] in women but not in men. None of the assessed blood parameters were associated with PUD in women, and only triglyceride level was associated with PUD in men (adjusted p = 0.0169, adjusted OR = 1.227 [1.037–1.451]).DiscussionWe found that obesity was associated with PUD in the Korean population; additionally, the association between nutritional components and PUD was greater in women than in men.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Kim

Lee

2017

PLoS ONE

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“…Among the subjects who had been examined in our outpatient clinic, vitamin B 12 deficiency was 4.8% (83/1716 patients). The median vitamin B 12 concentration was 142 pmol/L (IQR 122–154) (normal range 172–674) [ 33 ]. The median MMSE before treatment (baseline) was 22 (IQR 15–26), median Hcy was 16.7 mmol/mL (IQR 12.0–27.7) (normal range 3.7–13.5), and median folate was 6.8 pg/mL (IQR 5.0–8.4) (normal range 3.6−12.9) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

et al. 2022

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Vitamin B12 deficiency is associated with cognitive impairment, hyperhomocysteinemia, and hippocampal atrophy. However, the recovery of cognition with vitamin B12 supplementation remains controversial. Of the 1716 patients who visited our outpatient clinic for dementia, 83 had vitamin B12 deficiency. Among these, 39 patients (mean age, 80.1 ± 8.2 years) had undergone Mini-Mental State Examination (MMSE) and laboratory tests for vitamin B12, homocysteine (Hcy), and folic acid levels. The hippocampal volume was estimated using the z-score of the MRI-voxel-based specific regional analysis system for Alzheimer’s disease. This is multi-center, open-label, single-arm study. All the 39 patients were administered vitamin B12 and underwent reassessment to measure the retested for MMSE and Hcy after 21−133 days (median = 56 days, interquartile range (IQR) = 43–79 days). After vitamin B12 supplementation, the mean MMSE score improved significantly from 20.5 ± 6.4 to 22.9 ± 5.5 (p < 0.001). Hcy level decreased significantly from 22.9 ± 16.9 nmol/mL to 11.5 ± 3.9 nmol/mL (p < 0.001). Significant correlation was detected between the extent of change in MMSE scores and baseline Hcy values. The degree of MMSE score was not correlated with hippocampal atrophy assessed by the z-score. While several other factors should be considered, vitamin B12 supplementation resulted in improved cognitive function, at least in the short term, in patients with vitamin B12 deficiency.

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“…Indeed, intact gastrointestinal lining by gastric epithelium is one of the robust factors in gut defense and hence gut health (Pastorelli et al 2013). A cohort study conducted in Japan indicated that most patients with complicated peptic ulcers may have deficiency of one or more water-soluble vitamins including vitamin B 12 in the early phase of the disease before the onset of ulcer complications (Miyake et al 2013). It becomes therefore imperative to address the effect of vitamin B 12 deficiency during gastric ulcer condition and the status of ulcer during the treatment with vitamin B 12 enriched source, in this case, Spirulina platensis.…”

Section: Introductionmentioning

confidence: 99%

Gastro-protective potentials of Spirulina: role of vitamin B12

2019

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Gastric ulcer is a chronic health problem world over. Spirulina is known to contain significant amounts of vitamin B 12 hence Spirulina was evaluated for gastroprotective properties against gastric ulcerations. Spirulina biomass (SB) and Spirulina extract (SE) were evaluated in swim stress induced gastric ulcers in adult male albino rats. Both SB and SE inhibited 45% and 60% of ulcers formation induced by swim stress respectively. Gastroprotection has been elucidated to be due to inhibition of (a) upregulated H ? , K ? -ATPase activity that induced ulcer condition; (b) lipid peroxidation and (c) altered antioxidant enzyme levels. The data highlighted the importance of vitamin B 12 in protecting the gut against gastric ulcerations and suggested that both Spirulina biomass and Spirulina extract contain bioavailable B 12 . Spirulina based product/food can be used as alternatives to gastroprotective agents that are known to cause acidity themselves upon long term use.

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Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

Cited by 3 publications

References 34 publications

Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

Gastro-protective potentials of Spirulina: role of vitamin B12

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