Water Soluble Propolis and Royal Jelly Enhance the Antimicrobial Activity of Honeys and Promote the Growth of Human Macrophage Cell Line

Filipič, Bratko; Gradišnik, Lidija; Ružić‐Sabljić, Eva; Trtnik, Brabara; Pereyra, Adriana; Jaklič, Domen; Kopinč, Rok; Potokar, Jana; Puzić, Almin; Mazija, Hrvoje

doi:10.17265/2161-6264/2016.01.005

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…A possible novel strategy for the treatment of endothelial injury could be the use of honey, a natural product that in recent decades, as in ancient times, sparks interest for its several virtues and pharmacological properties [6,[29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium

Ranzato

Bonsignore

Patrone

et al. 2021

Cells

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Intracellular Ca2+ regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure, with particular interest in Ca2+ signaling involvement. The results highlight the positive effects of buckwheat honey on endothelial cells’ responses and the central role played by Ca2+ signaling as an encouraging target for more efficacious clinical treatments.

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Section: Discussionmentioning

confidence: 99%

Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium

Ranzato

Bonsignore

Patrone

et al. 2021

Cells

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“…A new strategy for endothelial injury treatment is to resort to using honey, due to its several virtues and pharmacological properties [26,54].…”

Section: Honey and Endothelial Repairmentioning

confidence: 99%

Applications of Beehive Products for Wound Repair and Skin Care

Martinotti,

Bonsignore,

Ranzato

2023

Cosmetics

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There is a long and interesting history between honeybees and humans. From the beginning, honey has been utilized not only as a sweetener, but also as an ointment and a drug to treat several diseases. Until the discovery of antibiotics, honey was a very popular product used to protect and preserve skin and promote wound healing, to counteract gastrointestinal pains and disorders of the oral cavity, and for other diseases. After the development of antibiotic resistance, honey again gained interest for its use in wound management. Subsequently, more recently, in vitro and in vivo studies have displayed antimicrobial, antioxidant, and other effects of honey and honeybee products, as well as protection of cardiovascular, respiratory, nervous, and gastrointestinal systems. Moreover, recent studies have demonstrated that beehive products are also able to influence the phenotype of skin cells, such as keratinocytes, fibroblasts, and endothelial cells, involved in correct wound healing. This review will characterize the great potential of honeybee products in the field of health and skin care, considering that honey is a virtually inexhaustible natural resource which people, as bees have been domesticated over the centuries, can freely access.

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Water Soluble Propolis and Royal Jelly Enhance the Antimicrobial Activity of Honeys and Promote the Growth of Human Macrophage Cell Line

Cited by 2 publications

References 31 publications

Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium

Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium

Applications of Beehive Products for Wound Repair and Skin Care

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