Water Soluble Nanocarbon Materials:A Panacea for All?

Abstract

Fictionalizations (fullerenes, CNTs & grapheme) help overcome the limitation of nanocarbon materials, making them soluble. Recently the emphasis has shifted to make water soluble Fullerenes (FWS). Much work has been documented showing the use of FWS in treating cancer (e.g. breast cancer), tumors, arthritis, Parkinson's, Influenzas & HIV-AIDS. Even an aqueous nasal spray to combat Alzheimer's has been advocated. A recent US patent shows that FWS is a powerful Radical Oxygen Scavenger (ROS) and thus shows anti-oxidant activity. FWS have been used in X-ray imaging, as MRI Contrast Agents (MRI-CA), to make solar cells and are expected to help produce nano-devices and biosensors.

Water-Soluble Pristine C60 Fullerenes Inhibit Liver Fibrotic Alteration and Prevent Liver Cirrhosis in Rats

“…They include, in particular, metal-based nanoparticles (Au, Ag, and Ce) and their oxides, liposomes, and micelles, which being conjugated with antifibrotic agents (cisplatin, doxorubicin, and curcumin), are capable of delivering them into the liver. Carbon-based nanostructure-C 60 fullerene-is one of the most powerful free radical scavengers [9,10]: 1 molecule of С 60 is able to bind up to 34 radicals depending on their size [11]. No toxic effect of water-soluble pristine C 60 fullerenes in the dose range of 75-150 mg/kg was observed on a mouse model (the LD 50 value was 721 mg/kg) [12].…”

The Role of Functionalization in the Applications of Carbon Materials: An Overview

“…The solubilization is the precondition for using carbon-based nanostructures in biomedical applications such as in vitro and in vivo imaging, photoacoustic imaging, drug delivery, protein separation, biosensing, tissue engineering and photothermal therapy [28,[63][64][65]. All these applications require the carbon particulate to be dispersed in solvents and particularly in water [66]. The hydrophobic character of carbon-based materials is generally attributed to the non-polarity of the bonds formed by sp 2 hybridized carbon atoms.…”

Influence of C60 Fullerenes on the Mechanokinetic and Biochemical Parameters of Muscle Soleus Contraction in Chronically Alcoholised Rats with Experimentally-Induced Ischemia

“…Сьогодні значну зацікавленість викликає нова алотропна модифікація вуглецю -фуллерени C 60 , яким притаманні унікальні фізико-хемічні властивості та біологічна активність [3][4][5]. Завдяки майже сферичній формі, нанорозміру та гідрофобним властивостям молекула C 60 здатна проникати через клітинні мембрани та локалізуватися всередині клітини, а завдяки наявності кон'югованої системи подвійних міжкарбонових зв'язків -взаємодіяти з ÀÔК та ефективно нейтралізувати їх [6][7][8][9].…”