Water-Soluble J-Type Rosette Nanotubes with Giant Molar Ellipticity

Abstract

A new self-assembling tricyclic module (×K1) featuring the Watson-Crick H-bonding arrays of guanine and cytosine fused to an internal pyridine ring was synthesized. When dissolved in water at room temperature, this module rapidly selfassembles into hexameric rosettes, which then stack to form J-type rosette nanotubes (RNTs) with increased inner/outer diameters and the largest molar ellipticity ever reported (4 × 10 6 deg • M -1 • m -1 ). Using a combination of imaging and spectroscopic techniques we established the structure of ×K1-RNT and have shown that the extended π system of the self-assembling module resulted in a new family of J-type RNTs with enhanced intermodular electronic communication.

Assembled molecular face-rotating polyhedra to transfer chirality from two to three dimensions

“…2d). The CD signals of both separated octahedra have a molar ellipticity of 4.6 × 10 6 deg cm 2 dmol −1 , which, to our knowledge, is the largest molar ellipticity ever reported50 and is substantially larger than that of helicene ( ca. 3.5 × 10 5 deg cm 2 dmol −1 )51.…”

Possible Existence of α-Sheets in the Amyloid Fibrils Formed by a TTR105–115 Mutant

“…Yet, another possible scenario is that the underlying fibril structure supports a supramolecular chirality, leading to a large in-crease in the CD signal, as has been observed for chiral helical stacks. 35–38 Irrespective of the interpretation, these CD spectra once again indicate that TTR-111D M form fibrils with a distinct structure.…”

Light-induced unfolding and refolding of supramolecular polymer nanofibres

“…A variety of functional SPs have been developed, while precise supramolecular polymerization has been devised recently, which is inspired by the biological system as well as synthetic polymers910. An important issue that has not yet been addressed in the context of SPs is dynamic control over their higher-order structures at the nanoscale (for example, helical coils), despite the fact that typical helical columnar structures at the primary level1112131415 have been well studied in terms of internal order. Changes in the higher-order conformation of biopolymers play an important role in biological systems, which is arguably best reflected in protein folding16.…”