Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

“…Lately, much interest has been focused on the chemistry and the biological activity of fused heterocyclic systems because of their broad spectrum of physiological activities [1,2]. Among these heterocyclic compounds carrying nitrogen atom, imidazo [2,1-b]thiazole derivatives possess specific importance because of their diverse pharmacological activities.…”

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

“…In the framework of our research on polycyclic nitrogen systems, [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] particularly referring to nortopsentin alkaloid analogues [34,35,36,37,38,39], herein we report the synthesis of the new series of thiazoles 1 (Table 1) and their evaluation as antibiofilm agents. In this series of nortopsentin analogues, the imidazole core of the natural product is replaced by the thiazole ring and one of the indole units is replaced by a 7-aza-indole moiety decorated with an ethanamine chain bound to the imine nitrogen.…”

Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents

“…Herein we report the one-pot synthesis of novel 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives from three component reactions of an 5-(4-chlorophenyl)-1,3,4-thiadiazol-2 amine (1), aromatic aldehydes (3) and malononitrile (2) in presence of NaOH under reflux and ultrasonic irradiation as shown in Scheme 1. To determine the optimal reaction conditions, the one pot reactions between 5-(4-chlorophenyl)-1,3,4-thiadiazol-2 amine (1), suitable aldehyde (3), malononitrile (2) were carried out using different solvents in the presence of NaOH as a catalyst at different mole percentage as shown in Table 1, the desired product was not formed when H 2 O was chosen as solvent and instead acetonitrile, methanol and dimethylformaide was chosen as solvent.…”

“…On the basis of source and action mechanisms, the anticancer drugs are classified as alkylating agents, antimetabolites, natural products, hormones and antagonistic, miscellaneous agents. Many scientists are intensively engaged in the development of new anticancer active agents that reveal a selective cytotoxicity for cancer cells over normal cells which is undoubtedly needed to treat the severe cancer disease more efficiently and is also less toxic, since many of the marketed anticancer drugs are toxic in nature [2][3][4].…”