Water-soluble conjugated polymer with near-infrared absorption for synergistic tumor therapy using photothermal and photodynamic activity

Zhou, Sirong; Yang, Cheng; Guo, Lixia; Wang, Haoping; Feng, Liheng

doi:10.1039/c9cc03744f

Cited by 32 publications

(37 citation statements)

References 40 publications

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“…To quantify the photothermal conversion performance of nanothylakoids, the PCE was calculated to be 30.8% by a reported method (Figure 2f,g). As shown in Figure 2h, the PCE of nanothylakoids was comparable to that of water-soluble conjugated polymer PTDBD (31%); [34] higher than black phosphorus (28.4%), [35] CuS nanocrystals (25.7%), [36] Au NRs (21%), [37] and Mito-CCY (9.5%); [38] lower than reported organic small molecule tfm-BDP (88.3%), [39] conjugated oligomer F8-PEG NPs (82%), [40] and Pdots (65%). [41] Most notably, the PCE of nanothylakoid was higher than FDA-approved ICG (15.1%), [42] implying its promising opportunity as a photothermal conversion platform derived from natural plants.…”

Section: Resultsmentioning

confidence: 61%

Biomimetic 4D‐Printed Breathing Hydrogel Actuators by Nanothylakoid and Thermoresponsive Polymer Networks

Zhao

Huang

et al. 2021

Adv Funct Materials

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Shape-morphing actuators, which can breathe with the accompany of morphology changes to mimic botanical events, are challenging to fabricate with soft hydrogel materials. Herein, 4D printed-smart hydrogel actuators are reported that can not only dynamically deform but also generate oxygen (O 2 ) upon external stimulations. The printed breathing actuators featured with spinach leaf-derived thylakoid membrane (nanothylakoid) for photothermal conversion and catalytical O 2 evolution, a poly(N-isopropylacrylamide) (PNIPA) thermoresponsive polymer network for generating deformation forces by swelling/shrinkage (rehydration/dehydration), and an asymmetric bilayer poly(N-isopropylacrylamide)/polyacrylamide (PNIPA/PAA) structure to amplify the mechanical motions. Upon thermal stimulation or laser irradiation, the actuator can reversibly bend/unbend because of the photothermal conversion of nanothylakoid and the printed thermoresponsive asymmetric bilayer structure. Additionally, the catalase-like property of nanothylakoid imparts the actuator with O 2 evolution capability to breathe for further mimicking botanical systems. Notably, 4D printing can greatly facilitate and simplify the actuator fabrication process, including adjusting the size and layer compositions. This artificial breathing actuator with photothermal and catalytical properties provides a strategy in designing intelligent hydrogel systems and proves to be a highly promising material candidates in the fields of 3D/4D printing, automated robotics, and smart biomedical devices.

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Section: Resultsmentioning

confidence: 61%

Biomimetic 4D‐Printed Breathing Hydrogel Actuators by Nanothylakoid and Thermoresponsive Polymer Networks

Zhao

Huang

et al. 2021

Adv Funct Materials

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“…[ 33 ] The photothermal conversion efficiency of aCMP nanosheets was evaluated by temperature variation profiles and calculated to be 41% at 808 nm (Figure S9a,b, the Supporting Information), surpassing previous reported conjugated polymer‐based nanomaterials and inorganic photothermal such as water‐soluble diketopyrrolopyrrole‐based conjugated polymer (31%), amphiphilic semiconducting polycomplex (38%), semiconducting polymer nanobioconjugates (30%), Au nanomaterials (21%), and MoS 2 nanosheets (24.3%). [ 40–44 ] The aCMP nanosheets were very efficient for photothermal conversion as incident photons could be converted to heat via the nonradioactive recombination processes and molecular vibrations in polymers (Figure S9c, the Supporting Information). [ 34,45 ]…”

Section: Resultsmentioning

confidence: 99%

Reversing Immunosuppression in Hypoxic and Immune‐Cold Tumors with Ultrathin Oxygen Self‐Supplementing Polymer Nanosheets under Near Infrared Light Irradiation

Jiang

Wang

et al. 2021

Adv Funct Materials

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Solid tumors are characterized by a hypoxic and immunologically “cold” microenvironment that dramatically limits the therapeutic outcomes of immunotherapy. Thus, strategies and materials that are capable of reversing immunosuppression in immune‐cold tumors are highly desired. Herein, it is reported that oxygen (O2) self‐supplementing conjugated microporous polymer nanosheets can be utilized to elicit a robust antitumor T cell immune response in the hypoxic and immunosuppressive tumor microenvironment. The ultrathin nanosheets can generate O2 through the water splitting reaction and produce massive reactive oxygen species (ROS) under near infrared light irradiation. Meanwhile, the unique photothermal property of the conjugated polymer nanosheets generates hyperthermia under irradiation. Consequently, they are able to maximize the immunogenic cell death (ICD) performance by inducing adequate damage‐related molecular patterns in hypoxic tumors. Other than fostering T cell infiltration by the elicited ICD, the loaded indoleamine 2,3‐dioxygenase in nanosheets can reverse the immunosuppression and empower ICD effect for efficient T cells priming. In vivo experiments conclusively prove that the designed polymer nanosheets exhibit great potential for tumor eradication, metastasis prevention, as well as long‐term survival. Such a photocatalytic platform opens up new paths for reversing immunosuppression in immune‐cold tumors and broadens the application of polymer‐based nanosheets for cancer therapy.

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“…The combination of ROS production by CPs under specific wavelengths of light and its photothermal conversion properties has been used in antitumor and antimicrobial PTT. [82] Combining PDT and PTT in the same system is to realize the synergistic killing of microorganisms by both photodynamic and photothermal effect. It improves the antimicrobial effect and biosafety, and, at the same time, is an effective way to prevent drug resistance.…”

Section: Dual-mode Phototherapymentioning

confidence: 99%

Conjugated Polymers for Combatting Antimicrobial Resistance

et al. 2022

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Antimicrobial resistance (AMR) is one of the major challenges in pathogenic infections, which endangers human health and brings devastating public health threats. Therefore, developing new materials to reduce the over-reliance on antibiotics or to replace antibiotics is in great need to solve this problem. Conjugated polymers (CPs) with excellent light-harvesting properties and good biocompatibility are ideal candidate materials for combatting AMR through photodynamic antimicrobial therapy (PACT) by sensitizing oxygen and photothermal therapy (PTT) by light to heat conversion. Significant works of CPs-based antimicrobial approaches have been reported in recent years. Herein, we summarize the types of CPs-based antimicrobial materials, illustrate their antimicrobial mechanisms, and discuss their applications in combating AMR mainly by PACT or antimicrobial PTT. In addition, we proposed some other antimicrobial treatment strategies based on CPs, hoping to provide inspiring insight for overcoming AMR.

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Water-soluble conjugated polymer with near-infrared absorption for synergistic tumor therapy using photothermal and photodynamic activity

Abstract: A novel NIR-absorbing and water-soluble conjugated polymer (PTDBD) for single-NIR-light induced synergetic photothermal/photodynamic therapy was developed.

Cited by 32 publications

References 40 publications

Biomimetic 4D‐Printed Breathing Hydrogel Actuators by Nanothylakoid and Thermoresponsive Polymer Networks

Biomimetic 4D‐Printed Breathing Hydrogel Actuators by Nanothylakoid and Thermoresponsive Polymer Networks

Reversing Immunosuppression in Hypoxic and Immune‐Cold Tumors with Ultrathin Oxygen Self‐Supplementing Polymer Nanosheets under Near Infrared Light Irradiation

Conjugated Polymers for Combatting Antimicrobial Resistance

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