The pH value is a very common chemical measurement and is an indicator of water quality. For dilute solutions of strong acids and bases, the pH is related to their concentration, and therefore, it's related to the required for neutralization dose of the reagent, a clear dependence. In this case, the pH value is quite reliable parameter to control the process of neutralization. However, when the wastewater components that have buffer properties, for example, mixtures of weak acids and bases and their salts in mixture with strong acids are present, the neutralization process is described already by a group of characteristics. In the last case, traditional automatic systems cannot cope with the qualitative pH regulation.The article is devoted to the mathematical statics model of a neutralization buffer of wastewater process development. Based on the formulated assumptions, this process was divided into stages. After considering the characteristics of each stage the mathematical model of the process was obtained. The theoretical research results are specified in the developed calculation algorithm of the total reagent dose which is required to neutralize the wastewater, which have strong and weak acids in its composition. The theoretical and practical research results were approbated in the design of automatic control system of the buffer wastewater neutralization process in the enterprise of low-waste technology.