Water Remediation from Pollutant Agents by the Use of an Environmentally Friendly Supramolecular Hydrogel

Giuri, Demetra; D’Agostino, Simone; Ravarino, Paolo; Faccio, Davide; Falini, Giuseppe; Tomasini, Claudia

doi:10.1002/cnma.202200093

Cited by 7 publications

(7 citation statements)

References 61 publications

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“…However, their application to the removal of PhACs from water is still at its beginning. Only recently, Giuri et al reported the use of Boc-protected tripeptide hydrogels for the removal of diclofenac from water [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

A Peptide-Based Hydrogel for Adsorption of Dyes and Pharmaceuticals in Water Remediation

Fortunato

Mba

2022

Gels

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The removal of dyes and pharmaceuticals from water has become a major issue in recent years due to the shortage of freshwater resources. The adsorption of these pollutants through nontoxic, easy-to-make, and environmentally friendly adsorbents has become a popular topic. In this work, a tetrapeptide–pyrene conjugate was rationally designed to form hydrogels under controlled acidic conditions. The hydrogels were thoroughly characterized, and their performance in the adsorption of various dyes and pharmaceuticals from water was investigated. The supramolecular hydrogel efficiently adsorbed methylene blue (MB) and diclofenac (DCF) from water. The effect of concentration in the adsorption efficiency was studied, and results indicated that while the adsorption of MB is governed by the availability of adsorption sites, in the case of DCF, concentration is the driving force of the process. In the case of MB, the nature of the dye–hydrogel interactions and the mechanism of the adsorption process were investigated through UV–Vis absorption spectroscopy. The studies proved how this dye is first adsorbed as a monomer, probably through electrostatic interactions; successively, at increasing concentrations as the electrostatic adsorption sites are depleted, dimerization on the hydrogel surface occurs.

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Section: Introductionmentioning

confidence: 99%

A Peptide-Based Hydrogel for Adsorption of Dyes and Pharmaceuticals in Water Remediation

Fortunato

Mba

2022

Gels

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“…Gelator 2 has been previously studied by our group and is able to form gels in mixtures of water and organic solvents (H 2 O/EtOH, H 2 O/ i PrOH) [ 30 ]. Despite our attempts using several triggers (GdL, calcium, arginine), this gelator is not able to form hydrogels but rather precipitates or crystalizes in the presence of water.…”

Section: Resultsmentioning

confidence: 99%

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

et al. 2023

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Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.

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“…Amide bonds are involved in H‐bonds, as well as polar side chains 10–12 . Aromatic moieties of protecting group or of side chains offer stacking interactions, 11,13,14 whereas apolar side chains can contribute with weak hydrophobic interactions 15–17 . Because of their usual biocompatibility 12,18,19 and the ease of rationalizing a good gelator by varying either protecting groups or amino acids, peptides have been thoroughly explored for their gelation abilities.…”

Section: Introductionmentioning

confidence: 99%

“…20 Nonetheless, gelators with similar structures often behave differently, some forming gels, some others forming crystals or precipitates. 15,21,22 In these last years, a large number of compounds and gelation conditions were tested, and the research in this field led to a remarkable improvement in understanding of general principles behind LMW gel formation and properties. 23,24 It should also be noticed that in this field, it is of extreme importance to work in a reproducible way, carefully controlling all the parameters and steps involved in the gelation process (solvent, concentration, time, temperature, etc.).…”

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confidence: 99%

A short oxazolidine‐2‐one containing peptide forms supramolecular hydrogels under controlled conditions

Ravarino

Giuri

Tomasini

2023

Journal of Peptide Science

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Low‐molecular‐weight hydrogels are made of a small percentage of small organic molecules dispersed in an aqueous medium, which may aggregate in several manners using different methods. However, often the organic gelator in water has poor solubility, so the addition of a solubilising agent is required. In the case of acidic gelators, this mainly consists of the addition of a strong base, that is sodium hydroxide, that deprotonates the acidic moiety, so the gelator molecules become more soluble and tend to assemble into micelles, forming a dispersion. Some gelators, however, are sensitive to the harsh pH and get hydrolysed. This is the case of some molecules presenting carbamates in their features, like Fmoc‐protected or oxazolidinone‐containing peptides. In this paper, we present a valid alternative to sodium hydroxide, by dissolving a tripeptide containing an oxazolidinone moiety in a phosphate buffer (PB) medium at pH 7.4. The results obtained with the NaOH dissolution are compared with the ones with PB, as both methods present advantages and drawbacks. The use of NaOH produces transparent but weak hydrogels, as it exposes the gelator to harsh conditions that end up in its partial hydrolysis, which is more pronounced at high concentrations (≥10 mM). Using PB to dissolve the gelator, this problem is completely avoided as no hydrolysis product has been detected in the hydrogels, which are very stiff although more opaque. By tuning the preparation conditions, we can obtain a wide variety of hydrogels, with the properties required by the final application.

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Water Remediation from Pollutant Agents by the Use of an Environmentally Friendly Supramolecular Hydrogel

Cited by 7 publications

References 61 publications

A Peptide-Based Hydrogel for Adsorption of Dyes and Pharmaceuticals in Water Remediation

A Peptide-Based Hydrogel for Adsorption of Dyes and Pharmaceuticals in Water Remediation

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

A short oxazolidine‐2‐one containing peptide forms supramolecular hydrogels under controlled conditions

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