Water Radiolysis: Influence of Oxide Surfaces on H2 Production under Ionizing Radiation

Caër, Sophie Le

doi:10.3390/w3010235

Cited by 488 publications

(330 citation statements)

References 88 publications

Supporting

Mentioning

309

Contrasting

Unclassified

Order By: Relevance

“…IR could directly damage the macromolecules, i.e., proteins, lipids, and DNA, the major target of IR-induced damage presents in the nucleus and mitochondria of the cell [29] . On the other hand, IR could collide with H2O molecules within the cell (80% of the cell is composed of water), causing the production of free radicals that are capable of damaging critical targets [30] . Free radicals can be defined as an atom, molecule or ion that has unpaired electrons [31] .…”

Section: Ir and Its Effects On The Cellmentioning

confidence: 99%

“…However, the nature of high-energy radiation can override the ability of damaged normal cell to repair, consequently causing another risk for carcinogenesis. Advances in radiation technology lead to significant improvements in delivering the radiation dose more precisely to the shape of the tumor and at the same time limit the dose of radiation to the normal cells [69] . On the other hand, protection of the normal tissues from radiation injury remains as a major goal as both cancer cells and normal cells that have close relationship regarding their location in the organ [70] , and it is not possible to exclude all normal tissues from the radiation field because the doses necessary to achieve tumor control usually overlap with those that can cause complications [71] .…”

Section: Radiotherapy and Therapeutic Ratiomentioning

confidence: 99%

See 1 more Smart Citation

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

View full text Add to dashboard Cite

The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

show abstract

Section: Ir and Its Effects On The Cellmentioning

confidence: 99%

Section: Radiotherapy and Therapeutic Ratiomentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

View full text Add to dashboard Cite

show abstract

“…Recent studies have demonstrated that ionizing irradiation increases the membrane potential, respiration, and ATP production in mitochondria, and causes ROS production in the mitochondria of tumor cells (24,25). These mitochondrial ROS are secondary products via a continual cascade of reactions initiated by the initial ROS (particularly hydroxyl radicals) (25,(30)(31)(32)(33). Importantly, these secondary metabolic processes occur about 12 h after ionizing irradiation, and induce long-lasting ROS production (24,25).…”

Section: -Ala Acts As a Radiosensitizer Via The Enhancement Of Delaymentioning

confidence: 99%

5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: Quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro

et al. 2014

View full text Add to dashboard Cite

Abstract. Postoperative adjuvant radiotherapy has important roles in multimodal treatment for highly aggressive malignant gliomas. Previously, we demonstrated that multi-dose ionizing irradiation with repetitive administration of 5-aminolevulinic acid (5-ALA) enhanced the host antitumor response and strongly inhibited tumor growth in experimental glioma. However, the mechanism of the radiosensitizing effect of 5-ALA is not known. Ionizing irradiation not only causes reactive oxygen species (ROS) formation initially by water radiolysis but also induces delayed production of mitochondrial ROS for mediating the long-lasting effects of ionizing irradiation on tumor cells. 5-ALA leads to high accumulation of protoporphyrin IX (PpIX) in the mitochondria of tumor cells, yet can also improve dysfunction of the mitochondrial respiratory chain in tumor cells. Here, we assessed the effect of 5-ALA-induced PpIX synthesis and delayed production of intracellular ROS after ionizing irradiation with 5-ALA in glioma cells in vitro. Temporal changes in intracellular 5-ALA-induced PpIX synthesis after ionizing irradiation in glioma cell lines were evaluated using flow cytometry (FCM). Then, the effect of 5-ALA on delayed production of intracellular ROS 12 h after ionizing irradiation in glioma cells was evaluated by FCM and confocal laser scanning microscopy. Ionizing irradiation had no effect on 5-ALA-induced PpIX synthesis in glioma cells. Delayed intracellular production of ROS was significantly higher than that just after ionizing irradiation, but 5-ALA pretreatment strongly enhanced the delayed intracellular production of ROS, mainly in the cytoplasm of glioma cells. This 5-ALA-induced increase in the delayed production of ROS tended to be higher in the case of 5-ALA treatment before rather than after ionizing irradiation. These results suggest that 5-ALA can affect tumor cells under ionizing irradiation, and greatly increase secondary intracellular production of ROS long after ionizing irradiation, thereby causing a radiosensitizing effect in glioma cells.

show abstract

“…Steel is expected to corrode under reducing conditions at a rate of a few micrometers a year, producing iron oxide minerals (e.g., magnetite) and gaseous hydrogen (H 2 ) (King, 2008;Marsh and Taylor, 1988). Another source of H 2 , but likely in lesser amounts, is the alpha-radiolysis of water after canister breaching (Le Ca€ er, 2011). H 2 is believed to build up at higher rates than can be dissipated via diffusion.…”

Section: Introductionmentioning

confidence: 99%

Rates of microbial hydrogen oxidation and sulfate reduction in Opalinus Clay rock

Bagnoud

Leupin

Schwyn

et al. 2016

Applied Geochemistry

View full text Add to dashboard Cite

a b s t r a c tHydrogen gas (H 2 ) may be produced by the anoxic corrosion of steel components in underground structures, such as geological repositories for radioactive waste. In such environments, hydrogen was shown to serve as an electron donor for autotrophic bacteria. High gas overpressures are to be avoided in radioactive waste repositories and, thus, microbial consumption of H 2 is generally viewed as beneficial. However, to fully consider this biological process in models of repository evolution over time, it is crucial to determine the in situ rates of microbial hydrogen oxidation and sulfate reduction. These rates were estimated through two distinct in situ experiments, using several measurement and calculation methods.Volumetric consumption rates were calculated to be between 1.13 and 1.93 mmol cm À3 day À1 for H 2 , and 0.14 and 0.20 mmol cm À3 day À1 for sulfate. Based on the stoichiometry of the reaction, there is an excess of H 2 consumed, suggesting that it serves as an electron donor to reduce electron acceptors other than sulfate, and/or that some H 2 is lost via diffusion. These rate estimates are critical to evaluate whether biological H 2 consumption can negate H 2 production in repositories, and to determine whether sulfate reduction can consume sulfate faster than it is replenished by diffusion, which could lead to methanogenic conditions.

show abstract

Water Radiolysis: Influence of Oxide Surfaces on H2 Production under Ionizing Radiation

Cited by 488 publications

References 88 publications

Research and Development of Radioprotective Agents: A Mini-Review

Research and Development of Radioprotective Agents: A Mini-Review

5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: Quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro

Rates of microbial hydrogen oxidation and sulfate reduction in Opalinus Clay rock

Contact Info

Product

Resources

About