Water/polymer interactions in poly(amidoamine) hydrogels by H1 nuclear magnetic resonance relaxation and magnetization transfer

Calucci, Lucia; Forte, Claudia; Ranucci, Elisabetta

doi:10.1063/1.2968606

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Their comprehensive structural characterization can be performed by high-resolution magic angle spinning (HRMAS) NMR spectroscopy [146]. Advanced NMR techniques allowed elucidating their interaction with water molecules both in the absence and presence of inorganic ions [147][148][149].…”

Section: Paa Hydrogels and As Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Ranucci¹,

Manfredi²

2019

Chemistry Africa

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Polyamidoamines (PAAs) are multifunctional polymers prepared from prim-or sec-amines by Michael-type polyaddition with bisacrylamides. The reaction is preferably carried out at room temperature in water and without added catalysts or organic solvents. The reaction is specific. The presence in the starting monomers of additional functions, leaving apart amine, thiol and phosphine groups, does not interfere with the polymerization process. Consequently, PAAs are a polymer class endowed with unusual structural versatility. Moreover, at pH > 7 they are hydrolytically degradable in aqueous media to harmless products mostly consisting of β-amino-propionic acids. Many PAAs are remarkably biocompatible notwithstanding their polycationic nature. These properties allow to prepare multifunctional polymeric structures suitable for many diversified applications in biotechnology, such as drug carriers, transfection promoters, antiviral and antimalarial agents, hydrogels scaffolds for tissue engineering. The objective of this paper is to fully report the PAA chemistry and the studied biotechnological applications of a vast PAA library.

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Section: Paa Hydrogels and As Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Ranucci¹,

Manfredi²

2019

Chemistry Africa

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“…Longitudinal relaxation of hydrogel‐associated water is governed by proton chemical exchange between protons of free water and exchangeable protons of the polymer, e.g ., protons from carboxylate, hydroxyl and amino groups ( Belton et al, ; Hills et al, , ; Belton , ; Calucci et al, ). Transverse relaxation depends on the rotational correlation time of the water molecules.…”

Section: Entrapment Of Water In Hydrogelsmentioning

confidence: 99%

“…In hydrogels, hydration water (water molecules in close interaction with the polymer chains) has different properties than “free water” trapped in the junction zones of the hydrogel network ( Hills , ). There is rapid exchange between “free water”, which tumbles freely and hydration water, which has a slower tumbling rate ( Fyfe and Blazek , ; Degrassi et al, ; Okada et al, ; Calucci et al., ; Prŭšová et al, ). Hills et al (, ) developed a microphase model for polysaccharide hydrogels, in which the observed relaxation time is weighted between the superjunction phase whose relaxation rate is hundred times higher than the one of the interstitial phase, e.g ., 718 ms −1 and 5.5 ms −1 for agarose, respectively .…”

Section: Entrapment Of Water In Hydrogelsmentioning

confidence: 99%

Biohydrogel induced soil–water interactions: how to untangle the gel effect? A review

Brax

Buchmann

Schaumann

2017

J. Plant Nutr. Soil Sci.

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Biohydrogels such as microbial exudates and root‐derived mucilage are soil‐born cross‐linked polymers, able to form porous three‐dimensional networks during water uptake. The gel effect is the variation of soil properties, such as soil hydrology and soil structural stability, resulting from biohydrogel swelling in soil. Conventionally, soil–water–hydrogel interactions are investigated by measuring soil bulk properties such as water retention curves and porosity, without further analyzing the effect of biohydrogel phases in soil on a quantitative basis. Therefore, the evaluation of advanced and novel methods for the characterization of biohydrogel phases in soil and soil–water–hydrogel interactions is necessary. This review evaluates currently available methods for their potential to analyze processes associated to the gel effect. A promising approach to investigate the spatio‐temporal distribution of biohydrogel phases in porous media is based on Nuclear Magnetic Resonance (NMR) such as 1H‐NMR relaxometry, as well as on imaging techniques such as Environmental Scanning Electron Microscopy (ESEM). Especially NMR techniques enable the identification of different water populations based on their differences in the relaxation, and thus the mobility of water molecules in biohydrogels and non‐gel water in soil pores. Rheology measures the flow behavior of biohydrogels, providing information on the structural behavior of the hydrogel network and its gelling mechanism. Soil rheology further quantifies the effect of the biohydrogel phases on the interactions between soil particles, and thus the impact on soil microstructural stability. However, rheology does not elucidate the spatio‐temporal distribution and structural state of biohydrogel phases in soil. All in all, a systematic combination of rheology, NMR and suitable imaging methods seems promising and necessary in order to elucidate the still widely unknown gel effect in soil.

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“…234 The interaction of water with PAA hydrogels in the absence and presence of inorganic ions was carefully studied by NMR techniques. [235][236][237] The potential of crosslinked PAAs as scaffolds for cell culturing and tissue regeneration started only recently. In a first paper, amphoteric PAA hydrogels were obtained from 2,2bisacrylamidoacetic acid, 2-methylpiperazine, and primary bis-amines as crosslinking agents.…”

Section: Release Of Bioactive Substances From Tailored Paa-based Hydrmentioning

confidence: 99%

Poly(amidoamine)s: Past, present, and perspectives

Ferruti

2013

J. Polym. Sci. Part A: Polym. Chem.

122

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Poly(amidoamine)s (PAAs) are a family of synthetic polymers obtained by stepwise polyaddition of prim-or sec-amines to bisacrylamides. Nearly all conceivable bisacrylamides and prim-or sec-amines can be employed as monomers endowing PAAs of a structural versatility nearly unique among stepwise polyaddition polymers. PAAs are degradable in aqueous media, including physiological fluids. Many of them are remarkably biocompatible notwithstanding their cationic character. PAAs are per se highly functional polymers and, in addition, can be further functionalized giving rise to an endless variety of polymeric structures meeting the requisites for applications in such apparently disparate fields as inorganic water pollutants scavengers, sensors, drug and protein intracellular carriers, transfection promoters, peptidomimetic antiviral and antimalarial agents. In this review, the unique chemistry of PAAs is discussed and a vast library of PAA structures and PAA applications from the beginning to the present days reported.

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Water/polymer interactions in poly(amidoamine) hydrogels by H1 nuclear magnetic resonance relaxation and magnetization transfer

Cited by 14 publications

References 42 publications

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Biohydrogel induced soil–water interactions: how to untangle the gel effect? A review

Poly(amidoamine)s: Past, present, and perspectives

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