Water-mediated oxalic acid catalysed one-pot synthesis of 2-(substituted phenyl) phthalazin-1(2<i>H</i>)-ones

Sangshetti, Jaiprakash N.; Khan, Firoz A. Kalam; Chouthe, Rashmi S.; Zaheer, Zahid; Ahmed, Rana Z.

doi:10.1016/j.jtusci.2014.12.002

Cited by 9 publications

(3 citation statements)

References 21 publications

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Section: Resultsmentioning

confidence: 99%

“…Otherwise, the second procedure, which is accomplished by using MW assisted where the reaction mixture is left overnight at RT, then precipitates filtered off, then washed with cold ethanol to give compounds 2-12 respectively, is shown in (Scheme 1). [44][45][46][47][48] The reaction mechanism of the cyclocondensation procedure between aryl β-phthalic acid and hydrazine derivatives. However, the most important principle is anucleophilic attack of NÀ N containing units on the carbonyl group synchronized with a ring closer to the constructed phthalazinone derivatives 2-12.…”

Section: Chemistrymentioning

confidence: 99%

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Microwave‐Assisted Synthesis of Phthalazinone Derivatives with Biological Activity and In Silico Antiproliferative Studies

Abubshait

Almalih

et al. 2022

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Several nitrogen heterocycles are considered as privileged scaffolds in drug discovery and are present in several drugs with diverse biological activities. Herein, we report the synthesis and characterization of phthalazinone derivatives by using a green synthesis protocol under microwave irradiation. The reduced reaction time and high yield are some of the advantages that render this procedure a greener alternative to conventional chemical synthesis. The structures of all new derivatives were confirmed by spectral analysis. Synthesized derivatives show an effective antimicrobial effect. These compounds were also screened for their in vitro anticancer activity against colon cancer cell line (HCT116). Among the synthesized derivatives are exhibited the highest anticancer activity with IC50 of 28.97±0.11, 66.25±0.14 and 76.04±0.09 μM respectively. The antiproliferative activity was supported by molecular docking studies that showed that phthalazinone derivatives would potentially act through inhibition of PARP. The simulation studies substantiated the biological results as an active compounds in term of binding interactions and scores.

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Section: Resultsmentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Microwave‐Assisted Synthesis of Phthalazinone Derivatives with Biological Activity and In Silico Antiproliferative Studies

Abubshait

Almalih

et al. 2022

ChemistrySelect

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“…Wood ash biocatalyst [63], alginic acid [64,65], boric acid [66], tartaric acid [67,68], citric acid [69][70][71], pectin [72], oxalic acid [73][74][75], saccharin [46,76,77], wool and keratin deriving from wool fibers [78][79][80], feathers [81][82][83][84], silk [85,86], plant derivatives, lemon juice [87,88].…”

Section: Natural Materials and Foods As Catalystsmentioning

confidence: 99%

Green Chemistry in Organic Synthesis: Recent Update on Green Catalytic Approaches in Synthesis of 1,2,4-Thiadiazoles

et al. 2022

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Green (sustainable) chemistry provides a framework for chemists, pharmacists, medicinal chemists and chemical engineers to design processes, protocols and synthetic methodologies to make their contribution to the broad spectrum of global sustainability. Green synthetic conditions, especially catalysis, are the pillar of green chemistry. Green chemistry principles help synthetic chemists overcome the problems of conventional synthesis, such as slow reaction rates, unhealthy solvents and catalysts and the long duration of reaction completion time, and envision solutions by developing environmentally benign catalysts, green solvents, use of microwave and ultrasonic radiations, solvent-free, grinding and chemo-mechanical approaches. 1,2,4-thiadiazole is a privileged structural motif that belongs to the class of nitrogen–sulfur-containing heterocycles with diverse medicinal and pharmaceutical applications. This comprehensive review systemizes types of green solvents, green catalysts, ideal green organic synthesis characteristics and the green synthetic approaches, such as microwave irradiation, ultrasound, ionic liquids, solvent-free, metal-free conditions, green solvents and heterogeneous catalysis to construct different 1,2,4-thiadiazoles scaffolds.

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Natural food additives as green catalysts in organic synthesis: a review

et al. 2021

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Water-mediated oxalic acid catalysed one-pot synthesis of 2-(substituted phenyl) phthalazin-1(2H)-ones

Abstract: 2015) Water-mediated oxalic acid catalysed one-pot synthesis of 2-(substituted phenyl) phthalazin-1(2H)-ones,

Cited by 9 publications

References 21 publications

Microwave‐Assisted Synthesis of Phthalazinone Derivatives with Biological Activity and In Silico Antiproliferative Studies

Microwave‐Assisted Synthesis of Phthalazinone Derivatives with Biological Activity and In Silico Antiproliferative Studies

Green Chemistry in Organic Synthesis: Recent Update on Green Catalytic Approaches in Synthesis of 1,2,4-Thiadiazoles

Natural food additives as green catalysts in organic synthesis: a review

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