WATER MEDIATED ONE-POT, FOUR COMPONENT SYNTHESIS OF 3,3-DIMETHYL-13-ARYL-3,4-DIHYDRO-1H-INDAZOLO[1,2-b]PHTHALAZINE-1,6,11(2H,13H)-TRIONES

Abstract

Keywords:Dimethyl phthalate, one-pot synthesis, green synthesis and water; 2H-indazolo[2,1-b]phthalazine-trione derivatives Water mediated one-pot, four-component synthesis of substituted 2H-indazolo[2,1-b]phthalazine-triones from dimethyl phthalate, hydrazine, dimedone and aromatic aldehydes have been reported in the presence of p-toluenesulfonic acid (PTSA) as catalyst at 100 °C for 1.5-2.0 h. This methodology offers several advantages such as good yields, short reaction time, simple procedure, mild condition and environmentally begins. * Corresponding Authors

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity

“…Phthalazinedione derivatives have been investigated for their wide range of natural activities and applications, which include anticancer, cardiotonic, cytotoxic, anti-inflammatory and antibacterial properties. 85 Rao and co-workers explored 86 a p -TSA (10 mol%) catalysed four-component single-pot synthesis of 2 H -indazolo[2,1- b ]phthalazine-trione derivatives by the reaction of an equimolar mixture of dimethyl phthalate, hydrazine, dimedone, and different aromatic aldehydes in water medium at 100 °C within a short period of time (Scheme 54). Here, the yield was not significantly affected by the substitutions of aromatic aldehydes.…”