Water-insoluble, nanocrystalline, and hydrogel fibrillar scaffolds for biomedical applications

Kang, Dong‐Hee; Kim, Dong-Yoon; Wang, Sungrok; Song, Dasom; Yoon, Myung‐Han

doi:10.1038/s41428-018-0053-7

Cited by 13 publications

(7 citation statements)

References 67 publications

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“…2; TAblE 1). Hydrogels made of bacterial cellulose form efficient matrices, hydrogel nanofibrillar network scaffolds or fibre composites for biomedical applications; for example, in wound dress ings that deliver human epidermal keratinocytes and dermal fibroblasts 24,[34][35][36] . Production and application of cellulose produced by Komagataeibacter xylinus have been extensively studied 37,38 , and a process for largescale production of bacterial cellulosebased 'rayon fibres' for use as wearable textiles has been developed.…”

Section: Main Classes Of Bacterial Polymersmentioning

confidence: 99%

Bacterial biopolymers: from pathogenesis to advanced materials

2020

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Section: Main Classes Of Bacterial Polymersmentioning

confidence: 99%

Bacterial biopolymers: from pathogenesis to advanced materials

2020

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“…Geometrical factors can also influence cell proliferation, cell-generated traction forces, and other cellular functions [37]. In general, studies on the effects of geometrical factors on cell interactions have mainly used polymer hydrogels, polymer casted substrates, electrospun fibrous scaffolds, and nanocrystalline substrates [38,39]. The micropatterning technique has been actively utilized to develop desired patterns or geometries on soft and hard materials.…”

Section: Engineered Materialsmentioning

confidence: 99%

“…The micropatterning technique has been actively utilized to develop desired patterns or geometries on soft and hard materials. Cross-linking, cleavage of hydrogen bonds, and hydration process along with stamping can be useful in constructing hydrogels with controlled geometry [39]. For example, a study employing soft PAAm hydrogel substrates with defined geometries has provided a great deal of information concerning human mammary epithelial (MCF-10A) cells’ behavior on symmetric and asymmetric geometries [40].…”

Section: Engineered Materialsmentioning

confidence: 99%

Molecular-Level Interactions between Engineered Materials and Cells

Jang

Jin

Shankar

et al. 2019

IJMS

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Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions between cells and materials may guide the design and construction of sophisticated artificial substrates, potentially enabling control of cells for use in various biomedical applications. In this review, we introduce recent research results that shed light on molecular events and mechanisms involved in the interactions between cells and materials. We discuss the development of materials with distinct physical, chemical, and biological features, cellular sensing of the engineered materials, transfer of the sensing information to the cell nucleus, subsequent changes in physical and chemical states of genomic DNA, and finally the resulting cellular behavior changes. Ongoing efforts to advance materials engineering and the cell–material interface will eventually expand the cell-based applications in therapies and tissue regenerations.

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“…PVA has attracted wide attention owing to non-toxic, hydrophilicity, and biocompatibility. A series of previous studies have been reported on tissue engineering, drug delivery, food industry, and environmental application ( Kadokawa 2016 ; Kang et al, 2018 ; Kchaou et al, 2021 ). Excellent hydrophilicity enables PVA to encapsulate and release drug, which is revealed by our previous research ( Liu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Antimicrobial Multilayered Nanofibrous Scaffolds-Loaded Drug via Electrospinning for Biomedical Application

Liu

Jia

Ouyang

et al. 2021

Front. Bioeng. Biotechnol.

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Nanofibers prepared by biobased materials are widely used in the field of biomedicine, owing to outstanding biocompatibility, biodegradable characters, and excellent mechanical behavior. Herein, we fabricated multilayered nanofibrous scaffolds in order to improve the performance of drug delivery. The composite layer-by-layer scaffolds were incorporated by hydrophobic poly(l-lactic acid) (PLA): polycaprolactone (PCL) and hydrophilic poly(vinyl alcohol) (PVA) nanofibers via multilayer electrospinning. Morphological and structural characteristics of the developed scaffolds measured by scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed smooth and uniform fibers ranging in nanometer scale. The differences in contact angles and Fourier transform infrared spectrum (FTIR) between single-layered PVA nanofibers and multilayered scaffolds verified the existence of PLA: PCL surface. In vitro biodegradable and drug release analysis depicted multilayered scaffolds had good biodegradability and potential for medical application. Due to the model drug incorporation, scaffolds exhibited good antibacterial activity against Escherichia coli and Staphylococcus aureus by the zone of inhibition test. These results revealed that the multilayered scaffolds were proved to be desirable antibacterial materials for biomedical application.

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Water-insoluble, nanocrystalline, and hydrogel fibrillar scaffolds for biomedical applications

Cited by 13 publications

References 67 publications

Bacterial biopolymers: from pathogenesis to advanced materials

Bacterial biopolymers: from pathogenesis to advanced materials

Molecular-Level Interactions between Engineered Materials and Cells

Fabrication of Antimicrobial Multilayered Nanofibrous Scaffolds-Loaded Drug via Electrospinning for Biomedical Application

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