Water/ice as sprayable sacrificial materials in low-temperature 3D printing for biomedical applications

Liao, Chao Yaug; Wu, Wei; Hsieh, Cheng‐Tien; Yang, Hung C.; Tseng, Ching-Shiow; Hsu, Shan‐hui

doi:10.1016/j.matdes.2018.10.009

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…After that, a hydrogel, or bioink, containing the cells of the future engineered tissue is used to cover the sacrificial deposit. After polymerization, the sacrificial hydrogel is removed by different methods, such as chemical degradation [ 18 ], photolithography [ 19 ], temperature [ 20 ] or mechanical extraction [ 21 ]. Finally, endothelial cells are seeded into the hollow channels from which the sacrificial material has been removed, generating a vascular network within the cells embedded in the hydrogel block ( Figure 2 ).…”

Section: Printing Methodsmentioning

confidence: 99%

Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization

et al. 2021

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In recent years, tissue engineering has achieved significant advancements towards the repair of damaged tissues. Until this day, the vascularization of engineered tissues remains a challenge to the development of large-scale artificial tissue. Recent breakthroughs in biomaterials and three-dimensional (3D) printing have made it possible to manipulate two or more biomaterials with complementary mechanical and/or biological properties to create hybrid scaffolds that imitate natural tissues. Hydrogels have become essential biomaterials due to their tissue-like physical properties and their ability to include living cells and/or biological molecules. Furthermore, 3D printing, such as dispensing-based bioprinting, has progressed to the point where it can now be utilized to construct hybrid scaffolds with intricate structures. Current bioprinting approaches are still challenged by the need for the necessary biomimetic nano-resolution in combination with bioactive spatiotemporal signals. Moreover, the intricacies of multi-material bioprinting and hydrogel synthesis also pose a challenge to the construction of hybrid scaffolds. This manuscript presents a brief review of scaffold bioprinting to create vascularized tissues, covering the key features of vascular systems, scaffold-based bioprinting methods, and the materials and cell sources used. We will also present examples and discuss current limitations and potential future directions of the technology.

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Section: Printing Methodsmentioning

confidence: 99%

Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization

et al. 2021

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“…designed a 3D printer that used different phases of water as sacrificial materials. 115 When a layer of material was deposited, water was sprayed on it and frozen, and the next layer of material was deposited and the process repeated. This novel process gave a new solution to overcome the limitations of simultaneously printing scaffold material with sacrificial material.…”

Section: D Printingmentioning

confidence: 99%

“…The example discussed in section 3.4 uniquely adopted the different phases of water in the fabrication process and make it possible to function as a sacrificial material. 115 As mismatch issue often occurs in multi-nozzle fabrication, future studies may focus on optimizing nozzle path generation algorithms to reduce dimensional errors. For bioprinting, current research mainly used sacrificial baths or molds to realize hollow structures, while future research could be done to improve the precision and diversity of shapes created by direct bioprinting processes.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Finally, biocompatible materials such as hydrogel cannot be heated and printed using a conventional 3D printer. Although it might be hard to control multi‐nozzles in a precise manner, Liao et al designed a 3D printer that used different phases of water as sacrificial materials 115 . When a layer of material was deposited, water was sprayed on it and frozen, and the next layer of material was deposited and the process repeated.…”

Section: Sacrificial Manufacturing Processesmentioning

confidence: 99%

“…Second, fabrication processes might be improved with novel fabrication strategies, as well as the advancement of printing software and equipment to overcome issues such as dimensional mismatch when applying multi‐axial equipment, limited control of structure and porosity, and residual toxicity of sacrificial materials. The example discussed in section 3.4 uniquely adopted the different phases of water in the fabrication process and make it possible to function as a sacrificial material 115 . As mismatch issue often occurs in multi‐nozzle fabrication, future studies may focus on optimizing nozzle path generation algorithms to reduce dimensional errors.…”

Section: Future Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications

Wang,

Zhou

2023

J Biomed Mater Res

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Three‐dimensional (3D) printing technology has progressed exceedingly in the area of tissue engineering. Despite the tremendous potential of 3D printing, building scaffolds with complex 3D structure, especially with soft materials, still exist as a challenge due to the low mechanical strength of the materials. Recently, sacrificial materials have emerged as a possible solution to address this issue, as they could serve as temporary support or templates to fabricate scaffolds with intricate geometries, porous structures, and interconnected channels without deformation or collapse. Here, we outline the various types of scaffold biomaterials with sacrificial materials, their pros and cons, and mechanisms behind the sacrificial material removal, compare the manufacturing methods such as salt leaching, electrospinning, injection‐molding, bioprinting with advantages and disadvantages, and discuss how sacrificial materials could be applied in tissue‐specific applications to achieve desired structures. We finally conclude with future challenges and potential research directions.

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3D Printing in Medicine for Preoperative Surgical Planning: A Review

2019

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The aim of this paper is to review the recent evolution of Additive Manufacturing (AM) within the medical field of preoperative surgical planning. The discussion begins with an overview of the different techniques, pointing out their advantages and disadvantages as well as an in-depth comparison of different characteristics of the printed parts. Then, the state-of-the-art with respect to preoperative surgical planning is presented. On the one hand, different surgical planning prototypes manufactured by several AM technologies are described. On the other hand, materials used for mimicking different living tissues are explored by focusing on the material properties: elastic modulus, hardness, etc. As a result, doctors can practice before performing surgery and thereby reduce the time needed for the operation. The subject of patient education is also introduced. A thorough review of the process that is required to obtain 3D Printed surgical planning prototypes, which is based on different stages, is then carried out. Finally, the ethical issues associated with 3D printing in medicine are discussed, along with its future perspectives. Overall, this is important for improving the outcome of the surgery, since doctors will be able to visualize the affected organs and even to practice surgery before performing it.

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Water/ice as sprayable sacrificial materials in low-temperature 3D printing for biomedical applications

Cited by 10 publications

References 42 publications

Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization

Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization

Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications

3D Printing in Medicine for Preoperative Surgical Planning: A Review

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