Water-fueled autocatalytic bactericidal pathway based on e-Fenton-like reactions triggered by galvanic corrosion and extracellular electron transfer

Yao, Jizheng; Jiang, Tao; Ji, Yucheng; An, Biwen Annie; Koerdt, Andrea; Cai, Zhengdong; Dong, Chaofang; Gao, Yan; Qi, Zhenhui

doi:10.1016/j.jhazmat.2022.129730

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…99% elimination rates for S. aureus and P. aeruginosa treated with concentrations of 16 g cm −2 for Ag and 176 g cm −2 for Ga for a treatment of app = 24 h. Ag/Ru (118) Disinfection of bacteria is attributed to production of H2O2 and O2 ENM devices are composed of electrically-polarized Cu(II)-Ag coating on surfaces. The ENM devices can be fabricated on to a range of surfaces in multiple settings for applications in homes, restaurants, hospitals, public places (such as railway stations and airports) and industry.…”

Section: Metal Antimicrobial Mechanism Resultsmentioning

confidence: 99%

Electrically-polarized nanoscale surfaces generate reactive oxygenated and chlorinated species for deactivation of microorganisms

Kohli,

Vargas-Lizarazo,

Ali

et al. 2024

Preprint

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Due to dwindling supply of new antibiotics, recent outbreaks of infectious diseases, and the emergence of antibiotic-resistant microorganisms, it is imperative to develop new effective strategies for deactivating a broad-spectrum of microorganisms and viruses. We have implemented electrically polarized nanoscale metallic coatings (ENM) that deactivate a wide range of microorganisms including Gram-negative and Gram-positive bacteria with greater than six-log reduction, in less than ten minutes of treatment. The electrically-polarized devices were also effective in deactivating lentivirus and C. albicans. The key to high deactivation effectiveness of ENM devices is electrochemical production of micromolar cuprous ions, which mediated reduction of oxygen to hydrogen peroxide. Formation of highly damaging species, hydroxyl radicals and hypochlorous acid, from hydrogen peroxide contributed to antimicrobial properties of the ENM devices. The electric polarization of nanoscale coatings represents an unconventional tool for deactivating a broad-spectrum of microorganisms through in-situ production of reactive oxygenated and chlorinated species.

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Section: Metal Antimicrobial Mechanism Resultsmentioning

confidence: 99%

Electrically-polarized nanoscale surfaces generate reactive oxygenated and chlorinated species for deactivation of microorganisms

Kohli,

Vargas-Lizarazo,

Ali

et al. 2024

Preprint

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“…[53b] The energy conversion antibacterial mechanism includes direct extracellular electron transfer (EET, electrobiological conversion), [18] photodynamic therapy (PDT, photochemistry conversion), [54] photothermal therapy (PPT, photothermal conversion), [55] sonodynamic therapy (SDT, mechano-chemistry conversion), [22] and so on (Figure 2). [23,56] It is widely known that most biological signal transformations are related to the chargetransfer process. [57] Some metal-based nanomaterials with high electronic activity can directly transfer "active" electrons to bacteria through functionalized electron-transfer proteins, [18] severely disrupting the transmembrane transport of electrons or ions and resulting in various physiological disorders.…”

Section: Energy Conversionmentioning

confidence: 99%

“…[ 58 ] In addition, a novel mechanism of ROS spontaneous release has been proposed, in which electrons triggered by the corrosion process of metal oxide catalysis form H 2 O 2 or other ROS. [ 56 ] In this process, metal electrons transfer to the electron acceptor of oxygen, driven by the chemical energy of different redox potential. Therefore, in addition to the direct transfer of active electrons to disrupt bacterial activity, transferring active electrons to an intermediate (such as oxygen) to produce other active molecules is an alternative antimicrobial reaction pathway.…”

Section: Antibacterial Mechanisms Based On Energy Conversion and Elec...mentioning

confidence: 99%

In the View of Electrons Transfer and Energy Conversion: The Antimicrobial Activity and Cytotoxicity of Metal‐Based Nanomaterials and Their Applications

Ouyang,

Wei,

et al. 2023

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The global pandemic and excessive use of antibiotics have raised concerns about environmental health, and efforts are being made to develop alternative bactericidal agents for disinfection. Metal‐based nanomaterials and their derivatives have emerged as promising candidates for antibacterial agents due to their broad‐spectrum antibacterial activity, environmental friendliness, and excellent biocompatibility. However, the reported antibacterial mechanisms of these materials are complex and lack a comprehensive understanding from a coherent perspective. To address this issue, a new perspective is proposed in this review to demonstrate the toxic mechanisms and antibacterial activities of metal‐based nanomaterials in terms of energy conversion and electron transfer. First, the antimicrobial mechanisms of different metal‐based nanomaterials are discussed, and advanced research progresses are summarized. Then, the biological intelligence applications of these materials, such as biomedical implants, stimuli‐responsive electronic devices, and biological monitoring, are concluded based on trappable electrical signals from electron transfer. Finally, current improvement strategies, future challenges, and possible resolutions are outlined to provide new insights into understanding the antimicrobial behaviors of metal‐based materials and offer valuable inspiration and instructional suggestions for building future intelligent environmental health.

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“…cadmium sulfide, − or the use of more electroactive microorganisms, e.g . Shewanella oneidensis , or both in semiconductor-decorated biohybrid systems is advantageous, − it still has several limitations, such as environmental impact, production costs, rate of electron transfer, and microbial growth state. − Therefore, methods that are more generally applicable to enhancing electron transfer in these systems remain urgently required. TiO 2 is a widely used and inexpensive photosensitizer in both industrial and research applications, − displaying excellent photostability.…”

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confidence: 99%

Synergistic Approaches for Enhanced Light-Driven Hydrogen Production: A Membrane-Anchoring Protein-Engineered Biohybrid System with Dual Photosensitizers Strategy

Li,

Yu,

Qin

et al. 2024

ACS Materials Lett.

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Sunlight-driven hydrogen production provides a sustainable solution for clean energy generation. Despite their potential, extracellular photosensitized biohybrid systems are typically hindered by sluggish electron transfer between semiconductor materials and microorganisms. Herein, we introduce a bioinspired development, the membrane-anchoring protein approach, to overcome this limitation. Using a membrane-anchoring protein incorporated with a TiO 2 binding peptide on engineered E. coli, we establish a proof-of-concept and demonstrate an 81-fold enhancement in electron transfer efficiency and 10.8-fold increase in hydrogen production. Unprecedented insights into the dynamics of the extracellular photosensitized biohybrid interface are revealed herein using methyl viologen as an electron shuttle. Additionally, introducing Eosin Y as a photosensitizer model enhances both the electron source and transfer efficiency, further boosting hydrogen production. The synergistic approach utilizing extracellular and intracellular dual photosensitizers overcomes the limitations of electron transfer, enhances the overall efficiency of the system, and creates a more efficient pathway for light-driven hydrogen production.

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Water-fueled autocatalytic bactericidal pathway based on e-Fenton-like reactions triggered by galvanic corrosion and extracellular electron transfer

Cited by 6 publications

References 44 publications

Electrically-polarized nanoscale surfaces generate reactive oxygenated and chlorinated species for deactivation of microorganisms

Electrically-polarized nanoscale surfaces generate reactive oxygenated and chlorinated species for deactivation of microorganisms

In the View of Electrons Transfer and Energy Conversion: The Antimicrobial Activity and Cytotoxicity of Metal‐Based Nanomaterials and Their Applications

Synergistic Approaches for Enhanced Light-Driven Hydrogen Production: A Membrane-Anchoring Protein-Engineered Biohybrid System with Dual Photosensitizers Strategy

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