Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells

Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies

“…This leads to a reduction in the nuclear presence of the transcription coactivators YAP/TAZ and a decrease in the expression of ferroptosis-promoting proteins such as ACSL4, epithelial membrane protein 1 (EMP1), and NADPH oxidase 4 (NOX4), thereby inhibiting ferroptosis ( Yang et al, 2019 ; He et al, 2022 ; Cui et al, 2023 ). Additionally, the ferroptosis regulator nuclear factor erythroid 2-related factor 2 (NRF2), under the regulation of the antioxidant response protein Kelch-like ECH-associated protein 1 (KEAP1), translocates to the nucleus, resulting in increased expression of anti-ferroptosis proteins such as heme oxygenase-1 (HO-1), FTH1, and GPX4, thus resisting ferroptosis ( Song et al, 2024 ). These regulatory factors play a crucial role in combating chemotherapy-induced cell death, underscoring the potential of modulating ferroptosis-related molecular pathways to reverse chemoresistance (as shown in Figure 2 ).…”