Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines

Yeh, Chia Feng; Wang, Kuo Chih; Chiang, Lien Chai; Shieh, Den En; Yen, Ming Hong; Chang, Jung San

doi:10.1016/j.jep.2013.04.040

Cited by 118 publications

(66 citation statements)

References 35 publications

(40 reference statements)

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“…Based on these results, it is possible that SIRT 1 could be an antiviral for RNA virus infections like MERS-CoV and EV 71. Containing the key phytochemical GA, licorice is generally associated with detoxication in TCM [56], and exhibits antiviral effect [57][58][59]. Others have found that GA activates SIRT1 in diabetic db/db mice [60] and increases the expression of SIRT1 in renal tubular epithelial cell line [61].…”

Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

114

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Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.

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Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

114

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“…Similar effects could be found in another major component of this formula, Aster tataricus L. f., from which root antitussive and anti-inflammatory mixture could be extracted [15]. Anti-inflammatory, antiviral, antiapoptotic, and/or antioxidant activities could also be found in minor components like Nepeta cataria L. [34], Pericarpium Citri Reticulatae [35, 36], Radix Glycyrrhizae Preparata [37], Tussilago farfara L. [38], Folium Perillae [39], and Zingiber officinale Roscoe [40]. Furthermore, saponin derived from root of Platycodon grandiflorus and alkaloids extracted from Fritillaria plants inhibit Muc5AC expression [41].…”

Section: Discussionmentioning

confidence: 64%

Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome

Gao

Wang

Jing

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objective. In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold-dryness syndrome (CDSCOPD) to relieve cough and sputum. However, the underlying mechanisms of MZP on treating CDSCOPD remain to be elucidated. Methods. COPD and CDSCOPD rat models were established; MZP was given to CDSCOPD rats in the last 7 days of the 97-day model establishment. Then the rats were subjected to lung function measurement. Pathological changes in lungs were observed through paraffin section and H&E staining. The mRNA and protein levels of AQP1, 4, and 5 and Muc5AC and Muc5B in lung were determined by quantitative RT-PCR and western blotting. NE levels was determined by ELISA. Results. The impaired lung functions were observed in rats exposed to cigarette smoke. Among all parameters evaluating lung functions, only tidal volume demonstrates a further decrease in CDSCOPD when compared with COPD, indicating further impaired pulmonary ventilation functions upon cold-dryness stimulation. The intervention of MZP effectively improved lung functions parameters, prevented the inflammations, and eliminated the increases of AQP4 and 5 and the decrease of Muc5AC in lung. Conclusion. MZP probably improves pulmonary functions in CDSCOPD through inhibiting lung inflammation, increasing expressions of AQPs, and decreasing Muc5AC expression in lung.

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“…Bezüglich antiviraler Wirkung scheint jedoch die rohe, unpräparierte Form (Gan cao) eine stärkere Wirkung zu erzielen als die in Honig präparierte. Besonders der Bestandteil 18β-Glycyrrhizinsäure (18β-GA) erwies eine potente Anti-RSV-Aktivität, mit Hemmung der viralen Anhaftung und Penetration in die Wirtszelle sowie Reduktion der Virenmenge innerhalb der Zellen und IFN-β-Stimulation (Feng 2013).…”

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Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines

Cited by 118 publications

References 35 publications

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome

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