Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering

Buchtová, Nela; D’Orlando, Angélina; Judeinstein, Patrick; Chauvet, O.; Weiss, Pierre; Bideau, Jean Le

doi:10.1016/j.carbpol.2018.08.143

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…54−58 Additionally, the nanofiber shape has contributed to improve the mechanical and diffusion properties of hydrogels for tissue engineering applications. 59,60 We investigated these nanocomposites by UV−vis spectroscopy and NMR relaxation analysis in order to unveil the effect of nanoparticles in the temperature-induced phase transition of thermosensitive hydrogels. The outcomes of this work open new approaches to develop and characterize stimuli-responsive multifunctional systems with dynamic properties.…”

Section: ■ Introductionmentioning

confidence: 99%

Probing the Structural Dynamics of the Coil–Globule Transition of Thermosensitive Nanocomposite Hydrogels

2021

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Nanocomposite hydrogels have emerged to exhibit multipurpose properties, boosting especially the biomaterial field. However, the development and characterization of these materials can be a challenge, especially stimuli-sensitive materials with dynamic properties in response to external stimuli. By employing UV–vis spectroscopy and NMR relaxation techniques, we could outline the formation and behavior of thermosensitive nanocomposites obtained by in situ polymerization of poly(N-vinylcaprolactam) (PNVCL) and mesoporous silica nanofibers under temperature stimuli. For instance, inorganic nanoparticles covalently linked to PNVCL changed the pattern of temperature-induced phase transition despite showing similar critical temperatures to neat PNVCL. Thermodynamic parameters indicated the formation of an interconnected system of silica and polymer chains with reduced enthalpic contribution and mobility. The investigation of water molecule and polymer segment motions also revealed that the absorption and release of water happened in a wider temperature range for the nanocomposites, and the polymer segments respond in different ways during the phase transition in the presence of silica. This set of techniques was essential to reveal the polymer motions and structural features in nanocomposite hydrogels under temperature stimuli, demonstrating its potential use as experimental guideline to study multicomponent nanocomposites with diverse functionalities and dynamic properties.

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Section: ■ Introductionmentioning

confidence: 99%

Probing the Structural Dynamics of the Coil–Globule Transition of Thermosensitive Nanocomposite Hydrogels

2021

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“…These hydrogels thus appear as promising materials for use in tissue engineering for cartilage, intervertebral disks or fibrillated heart, both due to potential micro-invasive surgery and due to sufficiently high water dynamics that are advantageous for the diffusion of nutrients, thus for the viability of cells. 2 Moreover, the SPR data showed that GY785 was able to interact physically with BMP-2 and TGFβ. Further this study also showed that, when compared to Si-HPMC alone, threedimensionally (3D)-cultured RACs in Si-HPMC/GY785 strongly expressed type II collagen (COL2) and aggrecan transcript.…”

Section: Silanized Hydroxypropyl Methylcellulose (Si-hpmc)mentioning

confidence: 99%

Review On Use Of Polymeric Hydrogel For Cartilage Regeneration.

surya¹,

Arjun²,

Shanmugarajan³

2021

Int J Life Sci Pharm Res

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The therapy for articular cartilage trauma was a major challenge in the medical field. However due to their 3D cross linking capability and tissue mimicking nature , hydrogel played a crucial role in cartilage regeneration. However, when compared to traditional gels, hydrogels have many distinct properties that make them desirable for several biomedical applications. Firstly, the compact size of the hydrogels enables it to pass through the compact needles and catheters, which is useful for minimally invasive cells and biological deliveries in case of cartilage tissue regeneration. Further, the physical interactions among the polymers also lead to shear thinning behavior that enables the solid-like consistency in case of hydrogel scaffolds without the need for chemical modifications. In general, the polymeric hydrogels thus approaching the ideal characteristics must adhere to the site of the application, relieve traumatic signs, facilitate the faster rate of cartilage regeneration and seek to restore the normal daily activities of the preclinical or clinical subjects. Furthermore, in this review addresses past and current efforts with a brief overview of the highlighted properties for cartilage repair applications of hydrogel scaffolds made from both natural and synthetic polymers. We reviewed the multi scale properties of the hydrogel scaffolds such as mechanical properties and porosity. Moreover, this review focuses primarily on illustrating the characteristics of ideal polymeric hydrogels that are compatible with cartilage repair.

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“…On the other hand, free water shows liquid‐to‐solid transition at about 0°C as usual. Another characteristic of free water is the free diffusion in the whole Si‐HPMC hydrogels regardless of the matrix, which is conducive to nutrient delivery (Buchtova et al., 2018; Hoffman, 2002; Sakai, Kuroki, & Satoh, 2008). A recent experiment has found that the oxygen concentration, a limiting factor of cell viability, is more dependent on the cell density than on polymer concentration (Figueiredo et al., 2018).…”

Section: Recent Advances Of Hydrogel Materials In Ivd Regenerationmentioning

confidence: 99%

Recent advances of hydrogel‐based biomaterials for intervertebral disc tissue treatment: A literature review

Zheng

2021

J Tissue Eng Regen Med

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Low back pain is an increasingly prevalent symptom mainly associated with intervertebral disc (IVD) degeneration. It is highly correlated with aging, as the nucleus pulposus (NP) dehydrates and annulus fibrosus fissure formatting, which finally results in the IVD herniation and related clinical symptoms. Hydrogels have been drawing increasing attention as the ideal candidates for IVD degeneration because of their unique properties such as biocompatibility, highly tunable mechanical properties, and especially the water absorption and retention ability resembling the normal NP tissue. Numerous innovative hydrogel polymers have been generated in the most recent years. This review article will first briefly describe the anatomy and pathophysiology of IVDs and current therapies with their limitations. Following that, the article introduces the hydrogel materials in the classification of their origins. Next, it reviews the recent hydrogel polymers explored for IVD regeneration and analyses what efforts have been made to overcome the existing limitations. Finally, the challenges and prospects of hydrogel‐based treatments for IVD tissue are also discussed. We believe that these novel hydrogel‐based strategies may shed light on new possibilities in IVD degeneration disease.

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Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering

Cited by 16 publications

References 39 publications

Probing the Structural Dynamics of the Coil–Globule Transition of Thermosensitive Nanocomposite Hydrogels

Probing the Structural Dynamics of the Coil–Globule Transition of Thermosensitive Nanocomposite Hydrogels

Review On Use Of Polymeric Hydrogel For Cartilage Regeneration.

Recent advances of hydrogel‐based biomaterials for intervertebral disc tissue treatment: A literature review

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