Water-driven noninvasively detachable wet tissue adhesives for wound closure

Huang, Hongjian; Xu, Renfeng; Ni, Peng; Zhang, Zhenghong; Sun, Changzheng; He, Huaying; Wang, Xinyue; Zhang, Lidan; Liang, Ziyi; Liu, Haiqing

doi:10.1016/j.mtbio.2022.100369

Cited by 11 publications

(11 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the interfacial adhesion is relatively weak to low surface energy adherends such as PE, PC, and PMMA because van der Waals and hydrophobic associations prevail at the interfaces. The interfacial toughness of mTA 5 -PAA/PEI 3 exceeds that of many reported wTA PEC hydrogel materials, such as polyTA–PETEA–PEGDA–agar and PAGU hydrogels with wet interfacial toughness values of 858 and 818 J/m 2 , respectively, and the interface toughness of our work is approximately 1.8 times that of both (Figure I and Table S3) ,,– and higher than that of common commercial TAs, such as commercially available cyanoacrylate (Histoyl) and fibrin sealant (Tisseel), both of which have interfacial toughness less than 20 J/m 2 …”

Section: Resultsmentioning

confidence: 45%

“…This test was based on a previous method with slight modifications . Cell suspensions in DMEM containing 1 × 10 5 3T3 embryonic fibroblasts were seeded on 24-well cell culture plates precoated with the hydrogel.…”

Section: Methodsmentioning

confidence: 99%

“…This test was based on a previous method with slight modifications. 37 Cell suspensions in DMEM containing 1 × 10 5 3T3 embryonic fibroblasts were seeded on 24-well cell culture plates precoated with the hydrogel. The plates were incubated in a CO 2 incubator at 37 °C for 3 h to allow cells to attach; then, loosely attached cells were rinsed off with PBS, and 2 mL of fresh medium was added and incubated for 2 days.…”

Section: Burst Pressure Of the Hydrogel On Wet Porcine Skinmentioning

confidence: 99%

See 2 more Smart Citations

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Wang,

Huang,

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important wet tissue adhesive. However, its relatively weak cohesive and adhesive strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) with a catechol group, a long alkyl hydrophobic chain, and a phenyl group was prepared first, and then, it was mixed with acrylic acid (AA) and polyethylenimine (PEI), followed by UV photopolymerization to make a wet tissue adhesive hydrogel with tough cohesion and adhesion strength. The hydrogel has a strong wet tissue interfacial toughness of ∼1552 J/m2, good mechanical properties (∼7220 kPa cohesive strength, ∼873% strain, and ∼33,370 kJ/m3 toughness), and a bursting pressure of ∼1575 mmHg on wet porcine skin. The hydrogel can realize quick and effective adhesion to various wet biological tissues including porcine skin, liver, kidney, and heart and can be changed easily with triggering urea solution to avoid tissue damage or uncomfortable pain to the patient. This biosafe adhesive hydrogel is very promising for wound closure and may provide new ideas for the design of robust wet tissue adhesives.

show abstract

Section: Resultsmentioning

confidence: 45%

Section: Methodsmentioning

confidence: 99%

Section: Burst Pressure Of the Hydrogel On Wet Porcine Skinmentioning

confidence: 99%

See 1 more Smart Citation

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Wang,

Huang,

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…The alkyl groups have a hemostatic activity by inserting into the cell membrane to trap the blood cells [ 143 ]. Dowling et al.…”

Section: Molecular Structure Design Of the Hemostasis Materialsmentioning

confidence: 99%

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Zou¹,

Li²,

Hu³

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

“…Uncontrollable bleeding and subsequent wound exposure are the main cause of many trauma-associated deaths, which have become a global health concern. 1,2 Consequently, there is an urgent need to develop fast, effective, and safe hemostatic and wound healing materials. 3 Nowadays, hemostatic materials mainly focus on active and passive combination hemostasis, in which active hemostasis can participate and activate the coagulation pathway in the body, while passive hemostasis involves blood absorption followed by the absorption behavior of haemoglobin and water to stop bleeding.…”

Section: Introductionmentioning

confidence: 99%