Water: Distribution Between Compartments and its Relationship to Thirst

Ramsay, D. J.

doi:10.1007/978-1-4471-1817-6_2

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Much of our understanding of the behaviors implicated in body fluid regulation has been based on studies of rats, dogs, and sheep (13,22,36,40,48). More recently, interest has developed in the body fluid regulatory aspects of mice (14,15,43,52), and specifically an interest in the genetic manipulation of the RAS of mice (6,9).…”

Section: Discussionmentioning

confidence: 99%

Investigations on the physiological controls of water and saline intake in C57BL/6 mice

Johnson

Beltz

Thunhorst

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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To examine the behavioral and neural control of body fluid homeostasis, water and saline intake of C57BL/6 mice was monitored under ad libitum conditions, after treatments that induce water or salt intake, and after ablation of the periventricular tissue of the anteroventral third ventricle (AV3V). Mice have nocturnal drinking that is most prevalent after the offset and before the onset of lights. When given ad libitum choice, C57BL/6 mice show no preference for saline over water at concentrations up to 0.9% NaCl and a progressive aversion to saline above that concentration. Systemic hypertonic saline, isoproterenol, and polyethylene glycol treatments are dipsogenic; however, systemic ANG II is not. Intracerebroventricular injections of both hypertonic saline and ANG II are dipsogenic, and diuretic treatment followed by a short period of sodium deprivation induces salt intake. After ablation of the AV3V, mice can be nursed to recovery from initial adipsia and, similar to rats, show chronic deficits to dipsogenic treatments. Taken together, the data indicate that mechanisms controlling thirst in response to cellular dehydration in C57BL/6 mice are similar to rats, but there are differences in the efficacy of extracellular dehydration-related mechanisms, especially for systemic ANG II, controlling thirst and salt appetite.

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Section: Discussionmentioning

confidence: 99%

Investigations on the physiological controls of water and saline intake in C57BL/6 mice

Johnson

Beltz

Thunhorst

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Acute elevation of blood glucose is not dipsogenic in either healthy volunteers (Zerbe & Robertson, 1983) or patients with IDDM (Thompson et al ., 1988) while urea has only weak dipsogenic properties (Zerbe & Robertson, 1983). Thirst may also be stimulated by hypotension or hypovolaemia (Ramsay 1991), although the mechanisms involved are not well understood. There are conflicting data regarding the effects of atrial natriuretic peptide (ANP) on thirst.…”

Section: Physiology Of Osmoregulationmentioning

confidence: 99%

Osmoregulation in clinical disorders of thirst appreciation

McKenna

Thompson

1998

Clinical Endocrinology

100

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The pseudohypoparathyroid disorders appear to represent a heterogeneous group with GNAS1 mutations forming the molecular aetiology in approximately 50% of pseudohypoparathyroidism type Ia families. Such mutations can be reliably identified by single-stranded conformational polymorphism and this will help to supplement the clinical evaluation of some patients and their families, particularly as the disease may not be fully penetrant.

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“…THE MAINTENANCE OF PLASMA osmolality within narrow limits is essential for cellular homeostasis (41). Small deviations are rapidly detected by central and peripheral osmoreceptors (19,21,32), which activate coordinated renal, neuroendocrine, and behavioral responses, to restore osmolality to normal levels (25,48).…”

mentioning

confidence: 99%

Inhibitory mechanism of the nucleus of the solitary tract involved in the control of cardiovascular, dipsogenic, hormonal, and renal responses to hyperosmolality

Blanch

Freiria-Oliveira

Murphy

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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The nucleus of the solitary tract (NTS) is the primary site of visceral afferents to the central nervous system. In the present study, we investigated the effects of lesions in the commissural portion of the NTS (commNTS) on the activity of vasopressinergic neurons in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei, plasma vasopressin, arterial pressure, water intake, and sodium excretion in rats with plasma hyperosmolality produced by intragastric 2 M NaCl (2 ml/rat). Male Holtzman rats with 15-20 days of sham or electrolytic lesion (1 mA; 10 s) of the commNTS were used. CommNTS lesions enhanced a 2 M NaCl intragastrically induced increase in the number of vasopressinergic neurons expressing c-Fos in the PVN (28 ± 1, vs. sham: 22 ± 2 c-Fos/AVP cells) and SON (26 ± 4, vs. sham: 11 ± 1 c-Fos/AVP cells), plasma vasopressin levels (21 ± 8, vs. sham: 6.6 ± 1.3 pg/ml), pressor responses (25 ± 7 mmHg, vs. sham: 7 ± 2 mmHg), water intake (17.5 ± 0.8, vs. sham: 11.2 ± 1.8 ml/2 h), and natriuresis (4.9 ± 0.8, vs. sham: 1.4 ± 0.3 meq/1 h). The pretreatment with vasopressin antagonist abolished the pressor response to intragastric 2 M NaCl in commNTS-lesioned rats (8 ± 2.4 mmHg at 10 min), suggesting that this response is dependent on vasopressin secretion. The results suggest that inhibitory mechanisms dependent on commNTS act to limit or counterbalance behavioral, hormonal, cardiovascular, and renal responses to an acute increase in plasma osmolality.

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Water: Distribution Between Compartments and its Relationship to Thirst

Cited by 6 publications

References 27 publications

Investigations on the physiological controls of water and saline intake in C57BL/6 mice

Investigations on the physiological controls of water and saline intake in C57BL/6 mice

Osmoregulation in clinical disorders of thirst appreciation

Inhibitory mechanism of the nucleus of the solitary tract involved in the control of cardiovascular, dipsogenic, hormonal, and renal responses to hyperosmolality

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