Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties

Abstract

International audienc

Coexistence of plasmonic and magnetic properties in Au89Fe11 nanoalloys

“…60,63 We therefore obtained the optical constant of an Au 89 Fe 11 alloy by the weighted average of the optical constants of pure gold and of an alloy with composition as close as possible to our particles among those available in the literature, i.e. of a bulk Au 84 Fe 16 alloy (measured by ellipsometry), 22 and thus we calculated the extinction spectrum of a 30 nm metal sphere by the Mie model. As shown in Fig.…”

“…60 However, it is worth noting that much lower plasmon damping is found in the extinction spectrum of 30 nm Au 89 Fe 11 NPs calculated by considering as the optical constant (3 Alloy ) the linear average of the optical constants of pure Au (3 Au ) and Fe (3 Fe ), i.e., 3 Alloy ¼ 0.893 Au + 0.113 Fe (dashed line in Fig. 3B), instead of using the experimental optical constant for the Au 84 Fe 16 alloy reported in ref. 22.…”

“…Because the optical constants of the Au 89 Fe 11 alloy are not available in the literature, we use the linear averaging of the optical constants of pure Au from ref. 87 and for Au 84 Fe 16 from ref. 22.…”

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

“…Unlike chemotherapy, hyperthermia induces cancerous cells undergoing apoptosis under high temperature conditions [102]. It also sensitizes cancer cells to radiation therapy or chemotherapy.…”

“…It also sensitizes cancer cells to radiation therapy or chemotherapy. Specifically, IONPs could locally convert external high-frequency field energy to thermal energy, which is called magnetic hyperthermia [102][103][104][105]. For example, magnetic hyperthermia mediated by IONPs could increase the temperature at the tumor center to greater than 40°C after exposing to alternating magnetic field [106], resulting in tumor growth inhibition in a human head and neck tumor xenograft model.…”