Water-dispersible hydroxyapatite nanoparticles synthesized in aqueous solution containing grape seed extract

Zhou, Ruchao; Si, Shaoxiong; Zhang, Qiyi

doi:10.1016/j.apsusc.2011.11.119

Cited by 46 publications

(20 citation statements)

References 39 publications

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“…However, the finial particles always aggregate easily in aqueous based solvent due to its high surface energy when the size of particles is in nanometer range [40]. In order to have better application in biomedical field, it is an important issue to take the fabrication of water-dispersible nanoparticles into consideration [41]. In this study, we have successfully synthesized Eu/Fe:HAp with various doping concentrations in water without addition of any surfactant, and those nanoparticles could be well re-suspended in culture medium (with 10% FBS) for a relatively long period of time (figure 5(a)).…”

Section: Resultsmentioning

confidence: 99%

Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles

Chen

Yoshioka

Ikoma

et al. 2014

Science and Technology of Advanced Materials

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Theranostic nanoparticles currently have been regarded as an emerging concept of ‘personalized medicine’ with diagnostic and therapeutic dual-functions. Eu3+ doped hydroxyapatite (HAp) has been regarded as a promising fluorescent probe for in vivo imaging applications. Additionally, substitution of Ca2+ with Fe3+ in HAp crystal may endow the capability of producing heat upon exposure to a magnetic field. Here we report a preliminary study of doping mechanism and photoluminescence of Eu3+ and Fe3+ doped HAp nanoparticles (Eu/Fe:HAp). HAp with varied concentration of Eu3+ and Fe3+ doping are presented as Eu(10 mol%):HAp, Eu(7 mol%)-Fe(3 mol%):HAp, Eu(5 mol%)-Fe(5 mol%):HAp, Eu(3 mol%)-Fe(7 mol%):HAp, and Fe(10 mol%):HAp in the study. The results showed that the HAp particles, in nano-size with rod-like morphology, were successfully doped with Eu3+ and Fe3+, and the particles can be well suspended in cell culture medium. Photoluminescence analysis revealed that particles have prominent emissions at 536 nm, 590 nm, 615 nm, 650 nm and 695 nm upon excitation at a wavelength of 397 nm. Moreover, these Eu/Fe:HAp nanoparticles belonged to B-type carbonated HAp, which has been considered an effective biodegradable and biocompatible drug/gene carrier in biological applications.

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Section: Resultsmentioning

confidence: 99%

Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles

Chen

Yoshioka

Ikoma

et al. 2014

Science and Technology of Advanced Materials

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“…They can also affect bone health, i.e., stimulating differentiation of healthy osteoblasts [4] and promoting the apoptosis of osteosarcoma cells [5]. These molecules are also able to influence bone density [6,7] and the in vitro deposition of hydroxyapatite [8,9].…”

Section: Introductionmentioning

confidence: 99%

Grafting of Gallic Acid onto a Bioactive Ti6Al4V Alloy: A Physico-Chemical Characterization

et al. 2019

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Despite increasing interest in the use of natural biomolecules for different applications, few attempts of coupling them to inorganic biomaterials are reported in literature. Functionalization of metal implants with natural biomolecules could allow a local action, overcoming the issue of low bioavailability through systemic administration. In the present work, gallic acid was grafted to a pre-treated Ti6Al4V in order to improve its biological response in bone contact applications. The grafting procedure was optimized by choosing the concentration of gallic acid (1 mg/mL) and the solvent of the solution, which was used as a source for functionalization, in order to maximize the amount of the grafted molecule on the titanium substrate. The functionalized surfaces were characterized. The results showed that functionalization with Simulated Body Fluid (SBF) as solvent medium was the most effective in terms of the amount and activity of the grafted biomolecule.A key role of calcium ions in the grafting mechanism is suggested, involving the formation of coordination compounds formed by way of gallic acid carboxylate and Ti-O − as oxygenated donor groups. Bioactive behavior and surface charge of the pre-treated Ti6Al4V surface were conserved after functionalization. The functionalized surface exposed a greater amount of OH groups and showed higher wettability.

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“…Green synthesis of HA got extensive scope because of its eco-friendly. Reducing, capping and stabilizing properties of many plant extracts such as Moringa oleifera leaf, gum-arabic, grape seed, banana, tamarind extract, Coccinia grandis and Azadirachta indica, orange, and potato peel, papaya leaf and calendula flower [10][11][12][13][14][15][16]. When an aqueous plant extract is used a green reducing agent during the synthesis of metal or metal oxide nanoparticles, explaining the role of a particular phytochemical is not an easy one.…”

Section: Introductionmentioning

confidence: 99%

Experimental studies on caffeine mediated synthesis of hydroxyapatite nanorods and their characterization

Subramanian¹,

Murugan²,

Chinnadurai³

et al. 2020

Mater. Res. Express

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Hydroxyapatite nanorods (HA) were fabricated using caffeine as a modifier at room temperature. Various concentrations of caffeine were utilized to synthesize the HA nanoparticles to analyze its effect on size, shape and morphology. The formation of phosphate ion was confirmed by Fourier Transform spectrophotometer (FTIR). Crystalline structure and phase of the nanoparticles was confirmed by x-ray diffraction study (XRD). The formation of HA nanorods with diversified morphology was confirmed by Transmission Electron Microscope (TEM) images. The results acquired in this study reveals that the HA nanoparticles synthesized using caffeine are uniform and evenly scattered nanorods. The average size of the nanorods obtained from the XRD study was in the range of 20-30 nm. The TEM and SAED investigation revealed the shape, morphology and arrangement of HA nanorods with higher crystallinity. This investigation claims that caffeine is a natural modifier to produce HA nanorods.

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Water-dispersible hydroxyapatite nanoparticles synthesized in aqueous solution containing grape seed extract

Cited by 46 publications

References 39 publications

Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles

Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles

Grafting of Gallic Acid onto a Bioactive Ti6Al4V Alloy: A Physico-Chemical Characterization

Experimental studies on caffeine mediated synthesis of hydroxyapatite nanorods and their characterization

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Water-dispersible hydroxyapatite nanoparticles synthesized in aqueous solution containing grape seed extract

Cited by 46 publications

References 39 publications

Photoluminescence and doping mechanism of theranostic Eu3+/Fe3+dual-doped hydroxyapatite nanoparticles

Photoluminescence and doping mechanism of theranostic Eu3+/Fe3+dual-doped hydroxyapatite nanoparticles

Grafting of Gallic Acid onto a Bioactive Ti6Al4V Alloy: A Physico-Chemical Characterization

Experimental studies on caffeine mediated synthesis of hydroxyapatite nanorods and their characterization

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Product

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Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles

Photoluminescence and doping mechanism of theranostic Eu³⁺/Fe³⁺dual-doped hydroxyapatite nanoparticles